Tag: 200-300

In 2019,Organic Letters included an article by Krishnamurti, Vinayak; Barrett, Colby; Ispizua-Rodriguez, Xanath; Coe, Matthew; Prakash, G. K. Surya. Application of 88-67-5. The article was titled 《Aqueous Base Promoted O-Difluoromethylation of Carboxylic Acids with TMSCF2Br: Bench-Top Access to Difluoromethyl Esters》. The information in the text is summarized as follows:

A method for the O-difluoromethylation of carboxylic acids using com. available TMSCF2Br is disclosed. The devised bench-top reaction system is air-stable and offers mild reaction conditions while using readily available reagents and solvents. The method is applicable to both aliphatic and aromatic carboxylic acids while demonstrating compatibility with a range of commonly encountered functional groups. The difluoromethyl esters of FDA approved drugs and pharmaceutically relevant mols. are also presented, demonstrating the potential for late-stage functionalization. The results came from multiple reactions, including the reaction of 2-Iodobenzoic acid(cas: 88-67-5Application of 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides.Application of 88-67-5 The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 3993-79-1On November 29, 2017 ,《Copper mediated coupling of 2-(piperazine)-pyrimidine iodides with aryl thiols using Cu(I)thiophene-2-carboxylate》 appeared in Tetrahedron Letters. The author of the article were Shrestha, Liza; Patel, Hardik J.; Kang, Yanlong; Sharma, Sahil; Chiosis, Gabriela; Taldone, Tony. The article conveys some information:

A copper-mediated synthesis of diaryl sulfides utilizing Cu(I)-thiophene-2-carboxylate (CuTC) is described. The use of CuTC as a soluble, non-basic catalyst in the coupling of aryl iodides and aryl thiols in the synthesis of synthetically advanced diaryl sulfides was demonstrated. This method allows for the successful coupling of challenging substrates including ortho-substituted and heteroaryl iodides and thiols. Addnl., most of the aryl iodide substrates used here contain the privileged piperazine scaffold bound to a pyrimidine, pyridine, or Ph ring and thus this method allows for the elaboration of complex piperazine scaffolds into mols. of biol. interest. The method described here enables the incorporation of late-stage structural diversity into diaryl sulfides containing the piperazine ring, thus enhancing the number and nature of derivatives available for SAR investigation. In addition to this study using 2-Amino-5-iodopyrimidin-4(1H)-one, there are many other studies that have used 2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1Recommanded Product: 3993-79-1) was used in this study.

2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Recommanded Product: 3993-79-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Ruthenium(II)-catalyzed synthesis of CF3-isoquinolinones via C-H activation/annulation of benzoic acids and CF3-imidoyl sulfoxonium ylides》 was written by Wen, Si; Zhang, Yuqing; Tian, Qingyu; Chen, Yanhui; Cheng, Guolin. Category: iodides-buliding-blocksThis research focused ontrifluoromethyl isoquinolinone preparation; benzoic acid trifluoromethyl sulfoxonium ylide activation annulation ruthenium catalyst. The article conveys some information:

A ruthenium(II)-catalyzed C-H activation/annulation reaction of benzoic acids and CF3-imidoyl sulfoxonium ylides enabled by weak O-coordination was achieved. A series of 3-trifluoromethyl-isoquinolinones I [R = Ph, 2-MeC6H4, CH2CH2Ph, etc.; R1 = 8-Me, 7-F, 6-I, etc.; R2 = F, CF2CF3, CF2CF2CF3] were synthesized in 37-75% yields under redox-neutral reaction conditions. In the experimental materials used by the author, we found 4-Iodobenzoic acid(cas: 619-58-9Category: iodides-buliding-blocks)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Category: iodides-buliding-blocksIodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

HPLC of Formula: 15854-87-2In 2021 ,《Construction of supramolecular hyperbranched polymers based on a tetrathiafulvalene derivative: Self-assembly and charge transfer interaction with TCNQ》 was published in Tetrahedron Letters. The article was written by Li, Xing-Long; Qin, Jie; Jiang, Man; Chen, Meng-Ning; Wang, Rong-Zhou; Yu, Shengsheng; Wang, Hai-Ying; Xing, Ling-Bao. The article contains the following contents:

In the present work, a four naphthyl-armed tetrathiafulvalene derivative (TTFB) was designed and synthesized through one-step reaction. Based on the host-guest interaction between naphthyl and cucurbit[8]uril (CB[8]), supramol. hyperbranched polymers (SHPs) can be constructed in water, depending on hydrogen NMR spectra, UV-vis absorption spectroscopy and diffusion-ordered NMR spectroscopy. The self-assembly properties of the SHPs were further investigated by zeta potential analyzer, dynamic laser light scattering and transmission electron microscopy measurements, which exhibited pos. charged spherical structures with the diameter at ∼120 nm. More interestingly, the SHPs can interact with TCNQ (7,7,8,8-tetracyanoquinodimethane) to form charge transfer complexes through charge transfer interaction. Meanwhile, the self-assembly structures can be transformed from spherical structures to crosslinked nanoparticles in the charge transfer complexes state. The experimental part of the paper was very detailed, including the reaction process of 4-Iodopyridine(cas: 15854-87-2HPLC of Formula: 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.HPLC of Formula: 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Zhou, Xian-Chao; Wu, Le-Xiong; Wang, Xue-Zhi; Lai, Ya-Liang; Ge, Ying-Ying; Su, Juan; Zhou, Xiao-Ping; Li, Dan published an article in Inorganic Chemistry. The title of the article was 《Self-Assembly of a Pd4Cu8L8 Cage for Epoxidation of Styrene and Its Derivatives》.Application In Synthesis of 4-Iodopyridine The author mentioned the following in the article:

Herein the authors report a discrete heterometallic Pd4Cu8L8 cage with a tubular structure, L = N,N’-(propane-1,3-diyl)bis(1-(1-(pyridin-4-yl)-1H-imidazol-4-yl))methanimine, which was synthesized by the assembly of copper metallo ligands and PdII ions in a stepwise manner. The Pd4Cu8L8 cage has been unequivocally characterized by single-crystal X-ray diffraction, electrospray ionization-mass spectroscopy, and energy dispersive spectroscopy. The cage showed excellent catalytic activity in the epoxidation of styrene and its derivatives under conditions without using addnl. solvent, providing potential material for catalyzing the oxidation reactions. After reading the article, we found that the author used 4-Iodopyridine(cas: 15854-87-2Application In Synthesis of 4-Iodopyridine)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Application In Synthesis of 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Park, Soyoon; Ryu, Soomin; Ho, Dongil; Chae, Wookil; Earmme, Taeshik; Kim, Choongik; Seo, SungYong published an article in New Journal of Chemistry. The title of the article was 《Novel benzo[b]thieno[2,3-d]thiophene derivatives with an additional alkyl-thiophene core: synthesis, characterization, and p-type thin film transistor performance》.Recommanded Product: 516-12-1 The author mentioned the following in the article:

In this paper, three novel organic materials based on the benzo[b]thieno[2,3-d]thiophene (BTT) core structure with an addnl. alkyl-thiophene core and end-capping alkyl side chains were synthesized and characterized. Furthermore, we explored the potential use of these compounds as solution-processed organic semiconductors (OSCs) for organic thin film transistors (OTFTs). Thermal, optical, and electrochem. properties of three organic compounds were investigated for elucidating the physicochem. information of each compound Then, the solution-shearing (SS) method was employed to form thin films of the compounds due to its merit with regard to mol. packing and thin film crystallinity, and microstructure as well as crystallinity of the thin films were investigated with θ-2θ X-ray diffraction (XRD) and at. force microscopy (AFM). All fabricated OTFTs exhibited p-channel activity under ambient conditions, and especially transistors based on the BTT core structure with a branched alkyl chain featured hole mobility up to 0.057 cm2 V-1 s-1 (VDS = -100 V) and current on/off ratio exceeding 107, in accordance with thin films of the corresponding compound showing superb surface coverage and high film texture. In the experiment, the researchers used many compounds, for example, 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Recommanded Product: 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Recommanded Product: 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Rao, Qing; Xie, Kaiqiang; Varier, Krishnapriya M.; Huang, Lei; Song, Jingrui; Yang, Jue; Qiu, Jianfei; Huang, Yubing; Li, Yan; Gajendran, Babu; Li, Yanmei; Liu, Sheng published an article in Frontiers in Pharmacology. The title of the article was 《Design, synthesis, and antileukemic evaluation of a novel mikanolide derivative through the Ras/Raf/MEK/ERK pathway》.SDS of cas: 63069-48-7 The author mentioned the following in the article:

Chronic myeloid leukemia (CML) accounts for a major cause of death in adult leukemia patients due to mutations or other reasons for dysfunction in the ABL proto-oncogene. The ubiquitous BCR-ABL expression stimulates CML by activating CDK1 and cyclin B1, promoting pro-apoptotic, and inhibiting antiapoptotic marker expression along with regulations in RAS pathway activation. Thus, inhibitors of cyclins and the RAS pathway by ERK are of great interest in antileukemic treatments. Mikanolide is a sesquiterpene dilactone isolated from several Asteraceae family Mikania sp. plants. Sesquiterpene dilactone is a traditional medicine for treating ailments, such as flu, cardiovascular diseases, bacterial infections, and other blood disorders. It is used as a cytotoxic agent as well. The need of the hour is potent chemotherapeutic agents with cytotoxic effects inhibition of proliferation and activation of apoptotic machinery. Recently, ERK inhibitors are used in clinics as anticancer agents. Thus, in this study, authors synthesized 22-mikanolide derivatives that elucidated to be potent antileukemic agents in vitro. However, a bioactive mikanolide derivative, I, was found with potent antileukemic activity, through the Ras/Raf/MEK/ERK pathway. It can arrest the cell cycle by inhibiting phosphorylation of CDC25C, triggering apoptosis, and promoting DNA and mitochondrial damage, thus suggesting it as a potential chemotherapeutic agent for leukemia patients. In the part of experimental materials, we found many familiar compounds, such as 4-Chloro-2-iodoaniline(cas: 63069-48-7SDS of cas: 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).SDS of cas: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Zhang, Jianyu; Alam, Parvej; Zhang, Siwei; Shen, Hanchen; Hu, Lianrui; Sung, Herman H. Y.; Williams, Ian D.; Sun, Jianwei; Lam, Jacky W. Y.; Zhang, Haoke; Tang, Ben Zhong published an article in Nature Communications. The title of the article was 《Secondary through-space interactions facilitated single-molecule white-light emission from clusteroluminogens》.Recommanded Product: 4-Iodobenzaldehyde The author mentioned the following in the article:

Clusteroluminogens refer to some non-conjugated mols. that show visible light and unique electronic properties with through-space interactions due to the formation of aggregates. Although mature and systematic theories of mol. photophysics have been developed to study conventional conjugated chromophores, it is still challenging to endow clusteroluminogens with designed photophys. properties by manipulating through-space interactions. Herein, three clusteroluminogens with non-conjugated donor-acceptor structures and different halide substituents are designed and synthesized. These compounds show multiple emissions and even single-mol. white-light emission in the crystalline state. The intensity ratio of these emissions is easily manipulated by changing the halide atom and excitation wavelength. Exptl. and theor. results successfully disclose the electronic nature of these multiple emissions: through-space conjugation for short-wavelength fluorescence, through-space charge transfer based on secondary through-space interactions for long-wavelength fluorescence, and room-temperature phosphorescence. The introduction of secondary through-space interactions to clusteroluminogens not only enriches their varieties of photophys. properties but also inspires the establishment of novel aggregate photophysics for clusteroluminescence. The results came from multiple reactions, including the reaction of 4-Iodobenzaldehyde(cas: 15164-44-0Recommanded Product: 4-Iodobenzaldehyde)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Recommanded Product: 4-Iodobenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shi, Qinjie; Ji, Yuanyuan; Shi, Yanxia; Zhao, Zhenjiang; Zhu, Weiping; Xu, Yufang; Li, Baoju; Qian, Xuhong published an article in 2021. The article was titled 《Fluoro-pyrazolo[3,4-d]pyrimidine derivative as a novel plant activator induces two-pathway immune system》, and you may find the article in Phytochemistry (Elsevier).Application of 626-02-8 The information in the text is summarized as follows:

Plants are known to develop a multi-faceted innate immune system for pathogenic defense. Systemic acquired resistance (SAR) and induced systemic resistance (ISR) are the two main pathways. Many chem. inducers known as plant activators that activate innate immunity to defend against pathogens have been discovered. Currently, the exploitation of new plant activators is mainly done to develop analogs of salicylic acid as SAR-signaling mols.; however, the ISR pathway is hardly investigated for new plant activators. Based on recent studies on 1-methylpyrazolo[3,4-d]pyrimidine bioactivity and ATP-induced resistance to biotrophic and necrotrophic pathogens, a new lead compound, 1-methyl-4-amino-pyrazolo[3,4-d]pyrimidine, was obtained as a new scaffold of plant activators for possible inducing ISR immunity system. Addnl., fluorine atom plays an important role in the design and development of new pesticides due to the unique phys. chem. effect, a series of pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesized. Several compounds showed good broad-spectrum induced resistance in vivo, but there was no direct antibacterial activity in vitro. Notably, the introduction of fluorine atom at the para-position of the benzene ring greatly enhanced the induction activity of I both involved in SAR and ISR pathways, which implied the inducing resistance both in defending pathogens and insects. In the experimental materials used by the author, we found 3-Iodophenol(cas: 626-02-8Application of 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Application of 626-02-8 Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xiong, Shuangyu; Sun, Wei; Chen, Rong; Yuan, Zhiqiang; Cheng, Xinjian published an article in 2021. The article was titled 《Fluorescent dialdehyde-BODIPY chitosan hydrogel and its highly sensing ability to Cu2+ ion》, and you may find the article in Carbohydrate Polymers.Safety of 1-Iodopyrrolidine-2,5-dione The information in the text is summarized as follows:

Fluorescent hydrogel with proper hydrophilicity and thermal stability, excellent sensitivity and high selectivity has important practical and scientific significance, especially in heavy metal ion detection. In this work, by adjusting the content of [2, 6-Bis-[4-formylthiophene]]-1,3,5,7-tetramethyl-8-phenyl-4, 4-difluoroborazaindoloene (B3), as a crosslinking agent, a series of chitosan- fluoroboron dipyrrole-chitosan-based fluorescent hydrogels (CBC) with large stokes shift were designed and prepared The hydrogels can be used as fluorescent probes for identifying Cu2+ in aqueous solution The linear quenching range of Cu2+ is 0-50 μM, and the detection limit and quenching constant are 4.75 μM and 3.52 x 104 M-1, resp. Under the interaction of Cu2+, the imine bond C=N was converted to C- N bond, which causes the phenomenon of fluorescence quenching. In addition, relatively high crosslink d. improves hydrophilicity and thermal stability of initial chitosan, and made the swelling ability better. The experimental part of the paper was very detailed, including the reaction process of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Safety of 1-Iodopyrrolidine-2,5-dione)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Safety of 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com