Tag: M.W=200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1878-94-0, name is 2-(4-Iodophenoxy)acetic acid, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-(4-Iodophenoxy)acetic acid

The mixture of camptothecin (30 mg, 0.086 mmol), 4-iodophenoxyacetic acid (36 mg, 0.18 mmol), EDCI (60 mg, 0.31 mmol), DMAP (5 mg, 0.047 mmol) and dichloromethane (5 ml) was stirred in the room temperature for 20 h, then dichloromethane (20 ml) was added to the solution. Organic layer was washed with water (20 ml), saturated NaHCO3 aqueous solution (10 ml) and brine (20 ml), and then dried over MgSO4. After the solvent was removed under reduced pressure, the resulting solid was separated by column chromatography (eluent: CHCl3:CH3OH 9:1) to afford 46 mg camptothecin-20-O-4-fluorophenoxyacetate, yield: 88.0%, mp 228-230 C. The chemical structure analysis was performed by 1HNMR (CDCl3, 600 MHz): delta 8.41 (s, 1H, Ar-H), 8.29 (d, 1H, Ar-H), 7.98 (d, 1H, Ar-H), 7.88 (t, 1H, Ar-H), 7.70 (t, 1H, Ar-H), 7.56 (s, 2H, Ar-H), 7.22 (s, 1H, Ar-H), 6.71 (m, 2H, Ar-H), 5.68 (d, 1H, H17), 5.40 (d, 1H, H17), 5.29 (s, 2H, H5), 4.82 (q, 2H, OCH2CO), 2.25 (d, 2H, CH2), 0.97 (t, 3H, CH3).

According to the analysis of related databases, 1878-94-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; California Pacific Medical Center; US6350756; (2002); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 104539-21-1, name is 1-Iodo-2-(2-methoxyethoxy)ethane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 1-Iodo-2-(2-methoxyethoxy)ethane

Naphthalene-2,7-diol (1) (3.0 g, 19 mmol) was added to compound 2 (4.83 g, 21 mmol) in 30 mL of acetone with K2CO3 (3 g, 21 mmol). The reaction was stirred for 24 h, and the reaction mixture was extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate, concentrated, and purified by silica gel column chromatography (20% ethyl acetate in hexane) to afford compound 3 as a white solid, yield (4.0 g, 82%). 1H NMR (600 MHz, CDCl3): delta 7.65-7.59 (m, 2H), 7.01-6.90 (m, 4H), 5.46 (s, 1H), 4.19 (t, J = 4.83 Hz, 2H), 3.90 (t, J = 4.83 Hz, 2H), 3.79-0.374 (m, 2H), 3.64-3.60 (m, 2H), 3.42 (s, 3H) ppm; 13C NMR (150 MHz, CDCl3): delta 157.23, 154.36, 135.86, 129.30, 129.13, 124.17, 116.19, 115.56, 108.82, 105.48, 71.95, 70.63, 69.74, 67.12, 59.03 ppm; MS (ESI): 263 [M+H]+.

The synthetic route of 104539-21-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jeong, Jaemyeng; Kumar, Rangaraju Satish; Mergu, Naveen; Son, Young-A.; Journal of Molecular Structure; vol. 1147; (2017); p. 469 – 479;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 351003-36-6, name is 2-Fluoro-5-iodobenzonitrile, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H3FIN

Add bis (triphenylphosphine) palladium (II) dichloride (77 mg, 0. 11 mmol), copper (I) iodide (42 mg, 0. 22 mmol), and 3-chloro-5-ethynylpyridine, (prepared as described in PREPARATION 27), (300 mg, 2. 2 mmol) to a solution of 2-fluoro-5-iodobenzonitrile (650 mg, 2. 6 mmol) in triethylamine (4. 6 mL, 33 mmol) and heat at 60 C for 6 h. Cool to room temperature and concentrate. Purify by silica gel chromatography, eluting with 50 : 50 dichloromethane : hexanes to 90 : 10 dichloromethane : ethyl acetate, followed by a second silica gel chromatography eluting with 95 : 5 to 75 : 25 hexanes : ethyl acetate, to give the title compound as an off-white solid (510 mg, 91%). 1H NMR (300 MHz, CH30H-d4) 8 7. 40-7. 48 (t, J = 8. 9 Hz, 1H), 7. 88-7. 97 (m, 1H), 8. 00-8. 09 (m, 2H), 8. 55-8. 58 (d, J = 2. 3 Hz, 1H), 8. 63-8. 66 (d, J = 1. 7 Hz, 1H) ; MS (APCI) : nz/z = 257 [M+H] +.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/94822; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 32024-15-0, These common heterocyclic compound, 32024-15-0, name is 3-Iodo-4,5-dimethoxybenzaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Synthesis of iodo-chrysin derivatives was accomplishedfollowing the general methods shown in Schemes 1 and 2.As outlined in Schemes 1 and 2, under anhydrous andanaerobic conditions, ZnCl2 (0.05 mol) was added to themixture of resorcinol (0.1 mol) and chloroacetonitrile (0.12mol) in diethyl ether (50 mL) cooled to 0C. The mixturewas reacted with anhydrous hydrogen chloride gas for 12hours. Intermediate compound 1, chrysin derivatives 2-5were synthesized according to Scheme 2. The Baker-VenKataraman reaction was employed in the synthesis ofchrysin derivatives [31]. 2, 4-dihydroxybenzoyl chloride (86mmol) was obtained after recrystallization with water. 2-Iodobenzaldehyde, 3-iodobenzaldehyde, 2-fluorine-5-iodobenzaldehyde or 3-iodo-4,5-dimethoxy benzaldehyde(12 mmol) and 10% NaOH (20 mL) were added to a solutionof compound 1 (10 mmol) in alcohol (5 mL). The mixturewas stirred at room temperature for 72 hours. Then the solutionwas acidified with 10% aqueous HCl to pH= 7 andstirred for another 48 hours at room temperature. The crudeproduce was purified by column chromatography (ethylacetate/ petroleum ether = 1:1) to get products, compound2: 7-hydroxy-2-(2-iodophenyl)-4H-chromen-4-one yielded62.7%, compound 3: 7-hydroxy-2-(3-iodophenyl)-4Hchromen-4-one yielded 61.5%, compound 4: 2- (2-fluoro-5-iodo- phenyl)-7-hydroxy-4H-chromen-4-one yielded 60.8%,compound 5:7-hydroxy-2-(3- iodo-4,5-di- methoxyphenyl)-4H-chromen-4-one yielded 62.3%. All compounds were yellowproducts.

The synthetic route of 32024-15-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wei, Yun; Zheng, Qutong; Tang, Guotao; Song, Chen; Wang, Guan; Zhang, Yinxiang; Xiao, Yan; Zeng, Xianliang; Wang, Zongbao; Xiao, Jichang; Zheng, Xing; Medicinal Chemistry; vol. 12; 5; (2016); p. 441 – 447;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 5471-81-8, name is Methyl 4-iodo-3-methylbenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5471-81-8, category: iodides-buliding-blocks

Under a protective atmosphere of inert gas, Pd(OAc)2 (2.2 mg, 10 mol%), XPhos (19.1 mg, 20 mol%), NBE-CO2K (3.5 mg, were added to a 4.0 mL reaction flask equipped with a magnetic stir bar. 10mol%),Methyl 3-methyl-4-iodobenzoate (0.2 mmol, 1.0 equiv.),Glycidyl butyrate (0.6 mmol, 3.0 equiv.)And dry N-methylpyrrolidone (1.0 mL).The reaction flask was capped and stirred at room temperature for about 5 minutes.The mixture was then heated to 80 C and stirred for 24 hours. After the reaction mixture was cooled to EtOAc EtOAc EtOAc m. Purified by column chromatography, the eluent was petroleum ether: ethyl acetate = 10:1 (v/v),53 mg of methyl 7-methyl-2-(butyryloxymethyl)-2,3-dihydrobenzofuran-5-carboxylate (light yellow oily liquid, yield 91%)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4-iodo-3-methylbenzoate, and friends who are interested can also refer to it.

Reference:
Patent; Wuhan University; Zhou Qianghui; Wu Chenggui; Cheng Honggang; (20 pag.)CN108329285; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 620621-48-9, name is Methyl 2-chloro-5-iodobenzoate, A new synthetic method of this compound is introduced below., SDS of cas: 620621-48-9

Intermediate 71 : methyl 2-chloro-5-(4-(dimethylamino)piperidin-l-yl)benzoate; Methyl 2-chloro-5-iodobenzoate (1.0Og, 3.37 mmol), cesium carbonate (0.360 mL,4.50 mmol), BINAP (0.070 g, 0.11 mmol), palladium(II) acetate (0.025 g, 0.11 mmol) and 4-(dimethylamino)piperidine (0.519 g, 4.05 mmol) were suspended in dioxane (18 mL) and sealed into a microwave tube. The reaction was heated to 120 0C for 3 hours in the microwave reactor and cooled to RT. The reaction mixture was filtered through celite. The crude product was purified by flash silica chromatography, elution gradient 0 to 10%NHVMeOH in DCM. Pure fractions were evaporated to dryness to afford methyl 2-chloro- 5-(4-(dimethylamino)piperidin-l-yl)benzoate (0.456 g, 68.3 %) as a yellow oil. m/z (ESI+) (M+H)+ =297.45; HPLC tR = 1.01 min. 1H NMR (400.13 MHz, CDC13) delta 1.56 – 1.66 (2H, m), 1.93 (2H, d), 2.24 – 2.29 (IH, m), 2.31 (6H, s), 2.71 – 2.78 (2H, m), 3.71 (2H, d), 3.92 (3H, s), 6.94 – 6.97 (IH, m), 7.27 – 7.28 (IH, m), 7.33 (IH, d).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AstraZeneca AB; AstraZeneca UK Limited; WO2009/47558; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 170112-66-0, The chemical industry reduces the impact on the environment during synthesis 170112-66-0, name is 3,4,5-Trifluoroiodobenzene, I believe this compound will play a more active role in future production and life.

(S) -2- (1 ,3-Dioxoisoindolin-2-yl) -Itf-methoxy- 3- (3 , 4 , 5-trifluorophenyl) ropanamide (28s) The starting material 25 (10.0 mmol, 2.48 g) , Pd(OAc)2 (1.50 mmol, 337 mg) , and AgOAc (20.0 mmol, 3.34 g) were weighed in air and placed in a sealed tube (350 mL) with a magnetic stir bar. To the reaction mixture, aryl iodide (15 mmol), 2,6- lutidine (3.00 mmol, 0.3 mL) , and HFIP (100 mL) were added. The reaction mixture was first stirred at room temperature for 10 minutes and then heated to 90 C for 36 hours under vigorous stirring. Upon completion, the reaction mixture was cooled to room temperature, and HFIP was recovered by distillation. The residue was filtered with DCM and concentrated as crude product 28s.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4,5-Trifluoroiodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; YU, Jin-Quan; WO2015/131100; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 82998-57-0, name is 3-Iodo-4-methylbenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 82998-57-0, Quality Control of 3-Iodo-4-methylbenzoic acid

Compound 5.3. Methyl 3-iodo-4-methylbenzoate. To a solution of 3-iodo-4- methylbenzoic acid (28.0 g, 0.107 mol) in MeOH (300 mL) at 0 C was carefully added concentrated H2SO4 (30 mL). The mixture was heated at 60 C overnight, then cooled and the solvent removed under reduced pressure. The residue was carefully poured onto ice- water (200 mL) and the mixture was extracted with EtOAc (500 mL). The organics was washed with water (100 mL), saturated NaHC03 (100 mL), brine (100 mL), dried (MgS04), filtered, and concentrated to yield the title compound as a brown oi 1 (29.0 g, 98%). ‘H NMR (400 MHz, CDCI3) delta 8.47 (d, J = 1 .7 Hz, 1 H), 7.90 (dd, J = 7.9 Hz, 1.7 Hz, 1 H), 7.29 (d, J= 7.9 Hz , 1 H), 3.90 (s, 2H), 2.48 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodo-4-methylbenzoic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; 3-V BIOSCIENCES, INC.; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.; WO2014/8197; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 460-37-7, The chemical industry reduces the impact on the environment during synthesis 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, I believe this compound will play a more active role in future production and life.

To a solution of 2.0 g (6.60 mmol) of the compound from Ex. 38A in 35 ml of DMF were added 2.30 g (16.6 mmol) of potassium carbonate, and the mixture was stirred at RT for 15 min. Then 2.3 ml (20.0 mmol) of 1,1,1-trifluoro-3-iodopropane were added. Since the conversion was still incomplete after stirring at RT for 3 days, the mixture was first stirred at 50 C. for 4.5 h, and then a further 0.92 g (6.60 mmol) of potassium carbonate and 0.78 ml (6.0 mmol) of 1,1,1-trifluoro-3-iodopropane were added. The reaction mixture was then stirred at 60 C. overnight. After cooling to RT, the mixture was diluted with water and stirred for 30 min. The precipitated product was filtered off with suction, washed to neutrality with water and dried. 2.15 g (78% of theory) of the title compound were obtained, which was used for subsequent reactions without further purification. LC/MS (Method 2, ESIpos): Rt=1.08 min, m/z=397 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,1-Trifluoro-3-iodopropane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; HAERTER, Michael; KOSEMUND, Dirk; CANCHO GRANDE, Yolanda; DELBECK, Martina; KALTHOF, Bernd; LUSTIG, Klemens; SUESSMEIER, Frank; US2020/16159; (2020); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 847685-01-2, name is 4,5-Difluoro-2-iodoaniline, A new synthetic method of this compound is introduced below., Quality Control of 4,5-Difluoro-2-iodoaniline

4,5-Difluoro-2-iodoaniline (Intermediate 27, 1.24 g, 4.86 mmol) was dissolved in anhydrous DMF (15 mL). Pyruvic acid (1.32 g, 15 mmol) and DABCO (1.68 g, 15 mmol) were added and the mixture degassed by alternate vacuum and nitrogen purge. Palladium EPO acetate (56 mg) was then added and the mixture heated to 1000C. for 2h. After cooling to ambient temperature the reaction mixture was filtered through celite, diluted with ethyl acetate (10OmL), washed with 2M HCl (2x 2OmL) and water (2x 2OmL), dried (MgSO4) and evaporated to give the title compound as a dark solid (860 mg, 90%). 1H NMR delta: 7.0 (s, IH), 7.3 (dd, IH), 7.6 (dd, IH), 11.9 (s, IH); MS m/z 196 (m-H)

The synthetic route of 847685-01-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/82400; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com