Tag: M.W=200-300

These common heterocyclic compound, 1643-29-4, name is 3-(4-Iodophenyl)propanoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 3-(4-Iodophenyl)propanoic acid

Next, the 4-iodohydrocinnamic acid is methylated. 350 g of the produced 4-iodohydrocinnamic acid is wet with 250 g water. To the mixture is added 1.4 L methanol and 1.5 g p-toluene sulfonic acid in water. The mixture is refluxed overnight, and excess methanol is removed. 500 mL toluene is added and mixed, and then excess toluene and water is removed. Next, 500 mL methanol is added to the mixture. The mixture is refluxed for 30 minutes, after which excess methanol is again removed. The result is 162 g of methyl-4-iodohydrocinnamic acid (61% purity).

The synthetic route of 3-(4-Iodophenyl)propanoic acid has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 52548-14-8, name is 2-Iodo-5-methylbenzoic acid, molecular formula is C8H7IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Iodo-5-methylbenzoic acid

Combine 1,2,3-triazole (3.45g, 50mmol), 2-iodo-5-methylbenzoic acid (5.24g, 20mmol), cesium carbonate (11.72g, 36mmol), trans-N, N ‘ -Dimethyl-1,2-cyclohexanediamine (0.51g, 3.6mmol), cuprous iodide (0.38g, 2mmol), N, N-dimethylformamide (30mL) were added to 100mL single-port round In a bottom flask, the temperature was gradually raised to 100 C under nitrogen protection for 4 hours. The reaction was stopped, cooled, diluted with tap water and extracted with ethyl acetate (200 mL × 2).The aqueous layer was acidified with concentrated hydrochloric acid (pH = 1-2) and extracted with ethyl acetate (200 mL × 2). The organic layers were combined, dried over anhydrous sodium sulfate, filtered, and the filtrate was evaporated to dryness under reduced pressure and purified by column chromatography ( Dichloromethane / methanol (v / v) = 50/1) gave the title compound (yellow solid, 2.76 g, 68%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 52548-14-8, its application will become more common.

Electric Literature of 25245-27-6, These common heterocyclic compound, 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 20Synthesis of (1 S,2R,4a5,8a5)-1 -(3,5-dimethoxyphenoxymethyl)-2,5,5,8a-tetramethyl-decahydronaphthalen-2-ol (Compound No. 34) In a sealed tube purged with nitrogen, 1-iodo-3,5-dimethoxybenzene (Compound No. 31, 0.78 g, 2.95 mmol), (1S,2R,4a5,8a5)-1-(hydroxymethyl)-2,5,5,8a-tetramethyl-decahydronaphthalen-2-ol (Compound No. 26, 0.65 g, 2.68 mmol), Cs2CO3 (1.3 g, 3.99 mmol), 3,4,7,8-tetramethyl-[1,10]-phenylthroline (0.12 g, 0.50 mmol), Cul (0.05 g, 0.26 mmol), diglyme (2 mL) and toluene (10 mL) were added. The reaction mixture was stirred at 120C for 18 h. The reaction was cooled to room temperature, diluted with EtOAc (300 mL) and washed with water (100 mL). The organic layer was dried (Na2SO4) and concentrated. Purification by column chromatography on silica gel (Hexanes/EtOAc, 2:1) gave (1 S,2R,4aS,8aS)-1 -(3,5-dimethoxyphenoxymethyl)- 2,5,5,8a-tetramethyl-decahydronaphthalen-2-ol (Compound No. 34, 0.71 g, 70%) as a colorless oil. 1H NMR (CDCI3): 66.08 (s, 3H), 4.20 (m, 2H), 3.75 (s, 6H), 3.08 (s, 1H), 1.95-1.30 (m, 1OH), 1.30 (s, 3H), 1.25-1.00 (m, 2H), 0.90 (s, 6H), 0.88 (m, 2H), 0.80 (s, 3H).

The synthetic route of 25245-27-6 has been constantly updated, and we look forward to future research findings.

Electric Literature of 460-37-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A solution of 880 mg (2.76 mmol) of the compound from Ex. 114A in 12 mL of DMF was treated with 1:35 g (4.15 mmol) cesium carbonate and stirred for 20 min at RT.Then 929 mg (4.15 mmol) 3,3,3-trifluoro-1-iodopropane were added, and the mixture was 2 h at 80 C heats.After cooling to RT was diluted with about 100 ml of ethyl acetate and washed twice with about 100 ml of water and once with 100 ml of saturated sodium chloride solution.After drying over anhydrous magnesium sulfate, was filtered and concentrated.The crude product was purified by preparative HPLC (method 6).The product fractions were combined and concentrated and the residue dried under high vacuum.There were 750 mg (63% d. Th.) Of the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,1-Trifluoro-3-iodopropane, other downstream synthetic routes, hurry up and to see.

Reference of 3032-81-3, These common heterocyclic compound, 3032-81-3, name is 1,3-Dichloro-5-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 1 (10mg, 0.057mmol), 2 (31mg, 0.114mmol) and CS2CO3 (95mg, 0.29mmol) in DMF (lmL) were added 2 mg of Pd(dba)2 and 2 mg of Xantphos. The suspension was degassed under vacuum and purged with N2 several times. The mixture was stirred at 120 °C for lh. LCMS showed the SM was consumed completely. Then the reaction mixture was diluted with EA (5mL) and washed with brine (2mL) twice. The organic solution was dried over anhydrous Na2SO4, filtered, concentrated under reduced pressure and purified by p-TLC to give the desired compound Compound 120 (6mg, yield: 33.3percent). LCMS: m/z, 321.0 (M+H)+; 1HNMR:(d-CDCl3, 400MHz): delta 8.65(s, 1H), 7.67(t, J=7.2, 1H), 7.45(d, J=7.6, 1H), 7.27(t, J=6.0, 1H), 6.70(s, 1H), 6.23(d, J=1.2, 2H), 4.14~4.30(m, 4H).

The synthetic route of 3032-81-3 has been constantly updated, and we look forward to future research findings.

Electric Literature of 82998-57-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 82998-57-0, name is 3-Iodo-4-methylbenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Synthesis of compound 6 (0048) 3-iodo-4-methyl-benzoic acid (compound 5:23.6 g, 0.09 mol) was added into THF (100 ml)and DMF (1 ml), then thionyl chloride (11.78 g, 0.099 mol) was added, rise the temperature to 60 C for 1 hour, evaporate the solvent, to give 3-iodobenzoyl chloride (compound 6), used directly for the next step.

The synthetic route of 3-Iodo-4-methylbenzoic acid has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 34883-46-0, name is 1-Iodo-2-phenoxybenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34883-46-0, Quality Control of 1-Iodo-2-phenoxybenzene

In a 2L three-necked flask,Into 44.4g (150mmol, 1.0eq.) 2- iodo diphenyl ether,Dissolved with 1000 ml of chloroform,An additional 16.8 g (300 mmol, 2.0 eq.) of potassium hydroxide was added.95.85 g (600 mmol, 4.0 eq.) of liquid bromine was added dropwise at room temperature.After the completion of the dropwise addition, the reaction was stirred at room temperature for 12 hours.The reaction was quenched with a saturated Na 2 SO 3 solution, and a large amount of solid was precipitated, stirred, suction filtered, washed with water, washed with ethanol, and recrystallized from chloroform and ethanol.Finally, 50 g of Intermediate-1 was obtained in a yield of 73.3%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-2-phenoxybenzene, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane, A new synthetic method of this compound is introduced below., name: 1,1,1-Trifluoro-4-iodobutane

2-(2,4-Dichlorophenyl)-5-methyl-1-[4-(4,4,4-trifluorobutoxy)-phenyl]-1H-imidazole-4-carboxylic acid piperidin-1-ylamide l-Iodo-4, 4,4-trifluorobutane (376 mg, 1.58 mmol) was added dropwise to a suspension of 2-(2,4-dichlorophenyl)-1-(4-hydroxyphenyl)-5-methyl-1H-imidazole-4-carboxylic acid piperidin-1-ylamide, from Ex 2, Step 1 (351 mg, 0.79 mmol) and K2CO3 (218 mg, 1.58 mmol) in 50 ml acetone. The reaction mixture was refluxed overnight, cooled, filtered and concentrated. Flash chromatography (silica, hexane: EtOAc 1: 2) afforded 200 mg (46%) of the title compound as a white solid. ‘H NMR (CDC13) : 8 8. 0 (1H, broad s), 7.4-7. 2 (3H, m), 7.1-7. 0 (2H, m), 6.9-6. 8 (2H, m), 4.1-4. 0 (2H, m), 3.0-2. 9 (4H, m), 2.5-2. 2 (5H, m), 2.2-2. 0 (2H, m), 1.9-1. 7 (4H, m), 1.6-1. 4 (2H, m). MS m/z 578 (M+Na). HPLC: 99.4%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 5876-51-7, The chemical industry reduces the impact on the environment during synthesis 5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole, I believe this compound will play a more active role in future production and life.

General procedure: To a solution of tetrabutylammonium bromide (1.100 g, 3.33mmol), potassium acetate (0.586 g, 3.57 mmol), and palladium acetate (0.025 g, 0.11mmol) in DMF (20 mL) were added substituted iodobenzene (2.21mmol) and substituted styrene (2.44 mmol). The reaction mixture was recharged with argon and stirred at 80C for 5 h in a sealed tube. The mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous NaCl and concentrated in vacuo. The residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate, 10:3) to afford pure product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Iodobenzo[d][1,3]dioxole, other downstream synthetic routes, hurry up and to see.

Electric Literature of 4387-36-4, A common heterocyclic compound, 4387-36-4, name is 2-Iodobenzonitrile, molecular formula is C7H4IN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

S1:100 mmol of the compound of the above formula (1), 200 mmol of the compound of the above formula (2), 0.4 mmol of palladium acetate, and 150 mmol of tetra-n-butylammonium bromide were added to an appropriate amount of the organic solvent N,N-dimethylacetamide (DMA) at room temperature. And 150 mmol of sodium carbonate, then stirred to raise the temperature to 120 ° C, and stirred at this temperature for 15 hours;After the reaction was completed, the reaction mixture was poured into a sufficient amount of ethyl acetate, and then washed with saturated brine, and the organic layer and aqueous layer were separated, and the aqueous layer was extracted with ethyl acetate. The organic layer and the organic layer obtained by ethyl acetate extraction were dried over anhydrous Na 2 SO 4 and evaporated under reduced pressure. The elution is carried out, the eluent is collected and the eluent is removed by evaporation.The compound of the above formula (3) is thus a white solid, the yield is 87.8percent;

The synthetic route of 4387-36-4 has been constantly updated, and we look forward to future research findings.