Tag: M.W=200-300

Related Products of 68507-19-7,Some common heterocyclic compound, 68507-19-7, name is 3-Iodo-4-methoxybenzoic acid, molecular formula is C8H7IO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 9. (3 -Difluoro-5-(5-methyl-[l ,2,41triazolo[l ,5-alpyrimidin-7-yl)piperidin- l-yl)(3-iodo-4-methoxy hen l)methanone. To a solution of 7-(5,5-difluoropiperidin-3-yl)-5-methyl-[l ,2,4]triazolo[l,5- a]pyrimidine (35 mg, 0.10 mmol) in DCM (0.32 mL) was added TEA (15.94 mu, 0.1 1 mmol), 3-iodo-4-methoxybenzoic acid (26.50 mg, 0.10 mmol), HOBt (17.51 mg, 0.1 1 mmol) and EDCI (21.92 mg, 0.1 1 mmol). The reaction was stirred at rt for 16 h. The crude reaction was filtered and the residue was purified by preparative reverse phase HPLC to afford the title compound (14 mg, 29%). 1H NMR (400 MHz, CDC13) delta = 8.58 (s, 1H), 7.95 (d, J = 1.96 Hz, 1H), 7.50 (dd, J = 8.41 , 2.15 Hz, 1H), 6.94 (br s, 1H), 6.86 (d, J = 8.61 Hz, 1H), 4.52 – 4.85 (m, 1H), 4.03 (br s, 2H), 3.88 – 3.99 (m, 3H), 3.23 – 3.58 (m, 2H), 2.65 – 2.76 (m, 5H), [M+H] = 514.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Iodo-4-methoxybenzoic acid, its application will become more common.

Synthetic Route of 128140-82-9, A common heterocyclic compound, 128140-82-9, name is 1-(Difluoromethoxy)-4-iodobenzene, molecular formula is C7H5F2IO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0712] Compound 655 was prepared following the similar procedure described in the synthesis of compound 593 where 1-(difluoromethoxy)-4-iodobenzene was used in place of XIII-10, and CuI Cs2CO3, and 8-hydroxyquinoline in DMSO/dioxane used as the reaction catalysts. The reaction mixture was purged with N2 and stirred at 110 C. overnight. In the last step coupling reaction, Pd-118 and K3PO4 were used in place of Pd(dppf)Cl2 and K2CO3. 1H NMR (DMSO-d6, 400 MHz) delta 8.10 (s, 1H), 7.79 (s, 1H), 7.54-7.51 (m, 3H), 7.32-7.14 (m, 4H), 6.59 (d, J=2.8 Hz, 1H), 4.51 (q, J=7.2 Hz, 2H), 3.85 (s, 3H), 1.33 (t, J=7.2 Hz, 3H).

The synthetic route of 128140-82-9 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 627-31-6, name is 1,3-Diiodopropane(stabilized with Copper chip), belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-31-6, COA of Formula: C3H6I2

In a 25 mL flask, xanthene (1, 350 mg, 1.92 mmol),dissolved in dry THF (10 mL) and diiodopropane (0.2 mL 1.74 mmol) were stirred under argon at 0 C. n-Butyllithium (1 mL, solution 2.5 M in hexanes) was added dropwise, after which the reactionwas heated up to room temperature. After approx 2 h (TLC 40% hexane-CHCl3 7:3), solvent was evaporated in vacuo. The crude product was dissolved in DCM (75 mL), washed three times withwater (30 mL), dried over Na2SO4 and taken to dryness in vacuo. The crude product was purified byflash column chromatography (0%-40% CHCl3 in hexane), to give 12 as a white powder, (410 mg,0.93 mmol, 48% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Diiodopropane(stabilized with Copper chip), other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 825-98-9, name is 3-Fluoro-4-iodobenzoic acid, A new synthetic method of this compound is introduced below., name: 3-Fluoro-4-iodobenzoic acid

To a solution of 3-fluoro-4-iodobenzoic acid (step-iof Intermediate-27, i.0 g, 3.75 mmol) inDMF (iO mL) was added K2C03 (i.07 g, 7.5i mmol), 2-bromo-N,N-diethylacetamide (i.09 g,5.63 mmol).The reaction mass was stirred at 80-90C for i6 h. The reaction mixture wasquenched with water, extracted with DCM. The organic layers were dried over Na2504 and concentrated to afford 0.500 g of title compound. ?H NMR (300 MHz, DMSO-d6): 8.09- 8.04 (t, J = 6.6 Hz, iH), 7.73-7.70 (t, J = 8.i Hz, iH), 7.60-7.57 (t, J = 7.8 Hz, iH), 5.03 (s, 2H), 3.30-3.i9 (q, J= 7.5 Hz, 4H), i.i7-i.i3 (t, J= 7.5 Hz, 3H), i.04-0.99 (t, J= 7.2 Hz, 3H);MS [M+Hf?: 380.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 6940-76-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6940-76-7 name is 1-Chloro-3-iodopropane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1-(3-Chloropropyl)-3,4-dihydro-1H-quinolin-2-one (85LM31) A 50 mL flask was charged with 3,4-dihydro-1H-quinolin-2-one (2.00 g, 13.6 mmol) and sodium hydride (60% in oil, 0.712 g, 16.3 mmol) in DMF (50 mL, dry) and stirred at 0 C. for 1 h, followed by addition of 1-chloro-3-iodo-propane (2.77 g, 13.6 mmol) and stirring at rt for 20 h. The reaction mixture was quenched with water (10 mL), and the product was extracted into EtOEt (3*25 mL). The combined organic layers were dried (Na2SO4), evaporated and purified by flash CC (SiO2; EtOAc/heptane 1:4) to give the crude title compound (85LM31) (2.25 g). 1H NMR (CDCl3) delta 7.29-7.22 (m, 1H), 7.17 (d, J=7.4 Hz, 1H), 7.08-6.98 (m, 2H), 4.10 (t, J=7.3 Hz, CH2), 3.62 (t, J=5.9 Hz, CH2), 2.88 (t, J=7.3 Hz, CH2), 2.63 (t, J=7.3 Hz, CH2), 2.19-2.10 (m, 2H); 13C NMR (CDCl3) delta 170.5, 140.0, 128.2, 127.8, 126.3, 123.2, 115.0, 43.3, 40.2, 32.2, 30.5, 26.0.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Chloro-3-iodopropane, and friends who are interested can also refer to it.

3819-88-3, name is 1-Fluoro-3-iodo-5-nitrobenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: iodides-buliding-blocks

Example 1 Step 1. To a solution of 1.0 eq IA in dry DMF (0.37 M) was added Zn(CN)2 (0.92 eq) and Pd(PPlIa)4 (0.058 eq). The reaction mixture was purged with nitrogen and heated to 800C overnight. An additional 0.023 eq of Pd(PPh3)4 was then added and the reaction was heated for another 6 hrs. The reaction mixture was then cooled to RT, diluted with 15 volumes of EtOAc (based on IA) and the organic layer was washed 3 times with water and once with brine. The organic layer was dried over sodium sulfate, filtered and concentrated. Purification by chromatography over silica gel using 10% E_2theta/hexane as the eluant provided IB as a solid (90%).

The synthetic route of 3819-88-3 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6940-76-7, name is 1-Chloro-3-iodopropane, This compound has unique chemical properties. The synthetic route is as follows., category: iodides-buliding-blocks

Into a 100-mL round-bottom flask was placed ACN (100 mL), 4-fluoro-2-methoxyphenol (5 g, 35.18 mmol, 1.00 equiv.), 1-chloro-3-iodopropane (14.4 g, 70.44 mmol, 2.00 equiv), and potassium carbonate (14.6 g, 105.64 mmol, 3.00 equiv). The resulting solution was stirred for 4 h at 80 C. The solids were filtered out. The resulting mixture was concentrated under vacuum. This resulted in 7.7 g (100%) of the title compound as a yellow oil. Analytical Data: LC-MS: (ES, m/z): RT = 1.365 mi m/z = 219 [M+1].

According to the analysis of related databases, 6940-76-7, the application of this compound in the production field has become more and more popular.

Application of 19094-56-5, The chemical industry reduces the impact on the environment during synthesis 19094-56-5, name is 2-Chloro-5-iodobenzoic acid, I believe this compound will play a more active role in future production and life.

Equipped with a thermometer, constant pressure dropping funnel, drying tube 1000mL flask was added three DCM200mL, VIII (70.62g, 250mmol) ,was added 1 ml of DMF and, at room temperature was slowly added dropwise oxalyl chloride (23.4mL g, 275mmol), was added dropwise after the completion of 20 incubated 2h.After adding concentrated to remove the DCM, oxalyl chloride 200mL DCM dissolved chloride.Equipped with a thermometer, constant pressure dropping funnel, 1000mL three 26mL flask with a drying tube was added fluorobenzene, DCM200mL the system temperature was dropped to -5 deg.] C, graded added to the system aluminum trichloride (36.67g, 275mmol) , dropped acid chloride prepared raw reaction incubated 6h completed.System 40mL conc HCl + 400mL poured into ice water to quench the reaction, the DCM. The combined organic phases were washed until neutral sodium bicarbonate, once with saturated brine separation was washed with water, dried, and concentrated to give VII84.23g, yield 93.4%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-5-iodobenzoic acid, other downstream synthetic routes, hurry up and to see.

Some common heterocyclic compound, 72373-82-1, name is 1-Chloro-2-fluoro-3-iodobenzene, molecular formula is C6H3ClFI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Chloro-2-fluoro-3-iodobenzene

(0112) A 500 mL flask was charged with 1-chloro-2-fluoro-3-iodobenzene (12.87 g, 65 mmol), [1,1′-biphenyl]-4-ylboronic acid (20 g, 78 mmol), potassium carbonate (8.98 g, 65 mmol), Pd(PPh3)4 (7.51 g, 6.5 mmol), toluene (280 ml), ethanol (140 ml) and water (140 ml). The resulting mixture was stirred, degassed and heated to 72C. for overnight. The reaction mixture was transferred into a separatory funnel, organic layer was separated, and aqueous layer was extracted with EtOAc. Combined organic layer was dried over Na2SO4, concentrated and the resulting residue was purified by column chromatography (EtOAc/heptane) to obtain 16.8 g (91% yield) of 3-chloro-2-fluoro-1,1′:4′,1”-terphenyl .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 72373-82-1, its application will become more common.

These common heterocyclic compound, 101335-11-9, name is 2-Chloro-4-fluoro-1-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 101335-11-9

To a solution of 2-chloro-4-fluoro-1 -iodo-benzene (9.0 g, 1 eq.) in DMF (46 ml.) was added cesium carbonate (22.8 g, 2 eq) then 4-chlorophenol (4.5 g, 1 eq.). The mixture was heated at 95 C for 16h. After cooling, an aq. solution of ammonium chloride (230ml_) was added, and extracted 3 times with diethylether. The organic phases were combined and washed successive- lywith an aq. solution of ammonium chloride (2x), aq. solution of NaOH (2%), water, then a saturated aq. solution of sodium chloride. The organic phase was dried and evaporated to give after purification on column chromatography on silica gel, 2-chloro-4-(4-chlorophenoxy)-1 -iodo- benzene as an oil (16,7 g, yield=47%).

The synthetic route of 2-Chloro-4-fluoro-1-iodobenzene has been constantly updated, and we look forward to future research findings.