Tag: M.W=200-300

Adding a certain compound to certain chemical reactions, such as: 6828-35-9, name is 5-Chloro-2-iodoaniline, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6828-35-9, SDS of cas: 6828-35-9

General procedure: Aryl iodide or bromides (5.0 mmol),paraformaldehyde (5.0 mmol), Pd(OAc)2 (0.0005 mmol) (for aryliodides) or Pd(PPh3)4 (0.05 mmol) (for aryl bromides) andCs2CO3 (7.0 mmol) were reacted in DMSO at 80 oCfor 12 h. The reaction mixture was poured into H2O, and extractedwith Et2O. The internal standard (dodecane) was added to theresulting mixture, and the conversion of aryl iodide and the yield of thehydrodehalogenated product were calculated.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloro-2-iodoaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Pyo, Ayoung; Kim, Sudeok; Kumar, Manian Rajesh; Byeun, Aleum; Eom, Min Sik; Han, Min Su; Lee, Sunwoo; Tetrahedron Letters; vol. 54; 38; (2013); p. 5207 – 5210;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 61272-76-2, The chemical industry reduces the impact on the environment during synthesis 61272-76-2, name is 4-Fluoro-2-iodoaniline, I believe this compound will play a more active role in future production and life.

A’-Benzyl~2~iodo~5~meihoxybenzamide (1.61 g, 4.38 mmol), 4-fIuoror-2-iodoani.ine (867 mg, 3.66 mmol), copper (I) iodide (139 mg, 0.73 mmol), and potassium carbonate (1.26 g, 9.12 mmol) were taken up in anhydrous DMSG (24 mL) and the resulting reaction mixture and the resulting reaction mixture was first stirred at 80 C for 2 hours, followed by heating to 135 C for another 16 hours. After cooling to room temperature, the mixture was filtered over celite and concentrated. The residue was diluted with an excess of Et?0 and washed with water. The organic layer was dried over Na2S04, filtered and concentrated. The residue was purified by flash column chromatography (EtOAc : Hex = 0: 100 to 100:0; then EtOAc : DCM = 0: 100 to 25:75) to give 10-Benzyl-8-fluoro-2-methoxy-5,lO-dihydro-l IH- dibenzo[6,e][1,4]diazepin~ i l~one (565 mg, 44%) as a light yellow foam.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Fluoro-2-iodoaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael S.; DE CLERCQ, Dries; JANG, Jaebong; JANNE, Pasi; TO, Ciric; ECK, Michael; PARK, Eunyoung; HEPPNER, David; (0 pag.)WO2019/164941; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13194-68-8, name is 4-Iodo-2-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., name: 4-Iodo-2-methylaniline

(a) Preparation of 4-Fluoro-2-(4-iodo-2-methyl-phenylamino)-benzoic acid To a stirred solution containing 3.16 g (0.0133 mol) of 2-amino-5-iodotoluene in 5 mL of tetrahydrofuran at -78 C. was added 10 mL (0.020 mol) of a 2.0 M lithium diisopropylamide in tetrahydrofuran/heptane/ethylbenzene (Aldrich) solution. The resulting green suspension was stirred vigorously for 15 minutes, after which time a solution of 1.00 g (0.00632 mol) of 2,4-difluorobenzoic acid in 10 mL of tetrahydrofuran was added. The reaction 2,4-difluorobenzoic acid in 10 mL of tetrahydrofuran was added. The reaction temperature was allowed to increase slowly to room temperature, at which temperature the mixture was stirred for 2 days. The reaction mixture was concentrated by evaporation of the solvent under reduced pressure. Aqueous HCl (10%) was added to the concentrate, and the solution was extracted with dichloromethane. The organic phase was dried (MgSO4) and then concentrated over a steambath to low volume (10 mL) and cooled to room temperature. The off-white fibers which formed were collected by vacuum filtration, rinsed with hexane, and dried in a vacuum-oven (76 C.; ca. 10 mm of Hg) to afford 1.10 g (47%) of the desired material; mp 224-229.5 C.; 1H NMR (400 MHz, DMSO): delta9.72 (s, 1H), 7.97 (dd, 1H, J=7.0, 8.7 Hz), 7.70 (d, 1H, J=1.5 Hz), 7.57 (dd, 1H, J=8.4, 1.9 Hz), 7.17 (d, 1H, J=8.2 Hz), 6.61-6.53 (m, 2H), 2.18 (s, 3H); 13C NMR (100 MHz, DMSO): delta169.87, 166.36 (d, JC-F=249.4 Hz), 150.11 (d, JC-F=11.4 Hz), 139.83, 138.49, 136.07, 135.26 (d, JC-F=11.5 Hz), 135.07, 125.60, 109.32, 104.98 (d, JC-F=21.1 Hz), 99.54 (d, JC-F=26.0 Hz), 89.43, 17.52; 19F NMR (376 MHz, DMSO): delta-104.00 to -104.07 (m); IR (KBr) 1670 (C=O stretch)cm-1; MS (CI) M+1=372. Analysis calculated for C14H11FINO2: C, 45.31; H, 2.99; N, 3.77. Found: C, 45.21; H, 2.77; N, 3.64.

According to the analysis of related databases, 13194-68-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Barrett, Stephen Douglas; Bridges, Alexander James; Doherty, Annette Marian; Dudley, David Thomas; Saltiel, Alan Robert; Tecle, Haile; US2003/78428; (2003); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 460-37-7, A common heterocyclic compound, 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, molecular formula is C3H4F3I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 2 was added to 21 three-necked bottles(5 (^, 0.167111 O1), 0.5111 O1 / 1He 0 field of liquid(84011 ^), stirmixLOmin. A solution of trifluoroiodopropaneLt; / RTI & gt;The reaction was stirred at room temperature4-5 hours.Add 5001 ^AcetateThe organic phase was dried over anhydrous sodium sulfate, filtered and the filtrate was evaporated to dryness to give 55.5 g of a yellow solid in 84% yield.

The synthetic route of 460-37-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang Yongning Pharmaceutical Co., Ltd; YE, TIANJIAN; LU, XIUWEI; YU, GUAMGLIANG; HE, SI; PAN, PENG; TIAN, JIAHUA; (10 pag.)CN105949258; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6828-35-9, name is 5-Chloro-2-iodoaniline, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 5-Chloro-2-iodoaniline

Under nitrogen protection, 4-((1S,4S)-4-(but-3-yn-2-yl)cyclohexyl)-6-fluoroquinoline (110 mg,0.39 mmol), 5-chloro-2-iodoaniline (99 mg, 0.39 mmol) and Et3N (118 mg, 1.2 mmol) of N,N-dimethylacetamideCuI (8 mg, 0.04 mmol) and Pd(PPh3)2Cl2 (29 mg, 0.04 mmol) were sequentially added to the solution (3 mL), and the reaction mixture was added.The reaction was stirred at room temperature for 4 h. TLC showed that after the reaction of the starting material was completed, NaOH (160 mg, 4.0 mmol) was added, and the temperature was raised to 140.Stir at C overnight, cool to room temperature, add water to the reaction mixture to quench, extract three times with EA, and combine with organicWash with brine, dry with anhydrous Na2SO4,The crude product obtained by concentration is passed through a thin layer chromatography plate.(DCM / MeOH = 25 / 1) was isolated and purified to give the title compound (90 mg, yield: 77%) as pale yellow solid.

According to the analysis of related databases, 6828-35-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chengdu Hai Borui Pharmaceutical Co., Ltd.; Chengdu Beite Pharmaceutical Co., Ltd.; Huang Haoxi; Liu Guanfeng; Ren Junfeng; Yi Shoubing; Chen Tonghun; He Quanhong; Wu Xiancai; Li Yingfu; Su Zhonghai; (97 pag.)CN109574988; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 444-29-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Pd(OAc)2 (45 mg; 0.2 mmol) and triphenylphosphine (115 mg; 0.44 mmol) were filled into anoven dried sealable tube and dissolved in dry MeCN (12 mL) under argon atmosphere. After5 min Cs2CO3 (3.26 g; 10 mmol), the aryl iodide (2 mmol), 1,3-dibromopropane (2.04 mL;20 mmol; for iodobenzene (1a): 2.24 mL; 22 mmol) and methylacrylate (906 muL; 10 mmol)were added. The reaction mixture was purged with argon for 5 min. After addition ofnorbornene (942 mg; 10 mmol) the tube was sealed and heated at 90 °C for 18 h.For workup the cooled reaction mixture was filtered over Celite®, washed with DCM,concentrated in vacuo and purified by column chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-2-(trifluoromethyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Stark, Tina; Suhartono, Marcel; Goebel, Michael W.; Lautens, Mark; Synlett; vol. 24; 20; (2013); p. 2730 – 2734;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 1829-28-3, The chemical industry reduces the impact on the environment during synthesis 1829-28-3, name is Ethyl 2-iodobenzoate, I believe this compound will play a more active role in future production and life.

In a test tube equipped with a stirrer and a septum cap, trifluoromethylzinc iodide (DMPU) 2 complex (160 mg, 0.2 mmol) prepared in Example 1 and copper (I) iodide (1.9 mg, 0.01 mmol ) Was charged, and argon substitution was carried out three times. Then, a solution of ethyl 2-iodobenzoate (16.6 mul, 0.1 mmol) in DMPU (0.2 ml) was added, the septum cap was replaced with a screw chap, and the reaction was carried out at 50 ° C. for 24 hours. After completion of the reaction, the reaction solution was quantified with 19 F-NMR (benzotrifluoride internal standard), and ethyl 2-trifluoromethylbenzoate was produced with a yield of 80percent

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-iodobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TOKYO INSTITUTE OF TECHNOLOGY; TOSOH F-TECH INCORPORATED; MIKAMI, MIKAMI; NAKAMURA, YUZO; NEGISHI, KAZUYUKI; AIKAWA, KOHSUKE; (8 pag.)JP5889817; (2016); B2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 217314-45-9, name is Methyl 3-amino-5-iodobenzoate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C8H8INO2

Step C: Mesylation; To a 0 C solution of aniline from step B (21.7 g, 78.3 mmol) in 3:1 1 CH2Cl2: pyridine (75 mL) was added methanesulfonyl chloride (6.36 mL, 82.2 mmol). The ice bath was removed after 15 min and the solution was stirred overnight at rt. The reaction mixture was extracted several times with IN HCI. The organic phase was dried, concentrated, and chromatographed (1:1 EtOAc:Hex) to afford 25.2 g of the desired sulfonamide as a white solid.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 217314-45-9.

Reference:
Patent; MERCK & CO., INC.; WO2005/103020; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 156150-67-3, The chemical industry reduces the impact on the environment during synthesis 156150-67-3, name is 2-Chloro-1-fluoro-4-iodobenzene, I believe this compound will play a more active role in future production and life.

2-chloro-1-fluoro-4-iodobenzene (771) mg) In the dioxane (5 mL) solution of tert-butyl 5-hydroxy-4-methyl-2,3-dihydro-1H-indole- 1-carboxylate (500 mg), and copper iodide (I) (38.2 mg), N,N-dimethylglycine (41.4 mg) and cesium carbonate (1.31 g) were added, and it stirred at 100 degrees C for 3 hours and 25 minutes. Cerite filtration of the reaction mixture was carried out after cooling to a room temperature. The mark compound (57.8 mg) was obtained as a colorless solid by condensing under decompression of the obtained filtrate and refining residue with silica gel column chromatography (ethyl acetate/hexane).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-1-fluoro-4-iodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DAIICHI SANKYO COMPANY LIMITED; NAGAMOCHI, MASATOSHI; GOTANDA, KENTOKU; GOTO, TAIJI; SASAKI, JUNKO; YOSHINO, TOSHIHARU; ISOBE, TAKASHI; (75 pag.)JP2016/128387; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 60577-34-6,Some common heterocyclic compound, 60577-34-6, name is 4-Iodo-N-methylaniline, molecular formula is C7H8IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

46.6 mg (0.2 mmol) of N-methyl 4-iodoaniline, 81.2 mg of ethyl bromodifluoroacetate (0.4 mmol), 2.5 mg (0.02 mmol) of cuprous acetate, 19.1 mg (0.04 mmol) of X-phos, 32.7 mg (0.2 mmol) of cesium carbonate were added to 2 mL of DMF solvent. The reaction was carried out at 110 C for 12 hours, after the reaction was completed, it was cooled, filtered, and the filtrate was evaporated. The solvent was removed and the residue was chromatographed on silica gel. It was washed with a mixed solution of petroleum ether and ethyl acetate in a volume ratio of 8:1. The effluent was collected according to the actual gradient, detected by TLC, and the effluent containing the product was combined. The solvent was distilled off by a rotary evaporator. Vacuum drying to give a yellow liquid N-(p-iodophenyl)-N-methylformamide 27.1 mg, yield 52%.

The synthetic route of 60577-34-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wenzhou University; Zhang Xiaohong; Li Xiaofang; Zhang Xingguo; (15 pag.)CN108774147; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com