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Iodide kinetics and experimental I-131 therapy in a xenotransplanted human sodium-iodide symporter-transfected human follicular thyroid carcinoma cell line

Uptake of iodide is a prerequisite for radioiodide therapy in thyroid cancer. However, loss of iodide uptake is frequently observed in metastasized thyroid cancer, which may be explained by diminished expression of the human sodium-iodide symporter (hNIS). We studied whether transfection of hNIS into the hNIS-deficient follicular thyroid carcinoma cell line FTC133 restores the in vivo iodide accumulation in xenografted tumors and their susceptibility to radioiodide therapy. In addition, the effects of low-iodide diets and thyroid ablation on iodide kinetics were investigated. Tumors were established in nude mice injected with the hNIS-transfected cell line FTC133-NIS30 and the empty vector transfected cell line FTC133-V4 as a control. Tumors derived from FTC133-NIS30 in mice on a normal diet revealed a high peak iodide accumulation (17.4% of administered activity, measured with an external probe) as compared with FTC133-V4 (4.6%). Halflife in FTC133-NIS30 tumors was 3.8 h. In mice kept on a low-iodide diet, peak activity in FTC133-NIS30 tumors was diminished (8.1%), whereas thyroid iodide accumulation was increased. In thyroid-ablated mice kept on a low-iodide diet, half-life of radioiodide was increased considerably (26.3 h), leading to a much higher area under the time-radioactivity curve than in FTC133-NIS30 tumors in mice on a normal diet without thyroid ablation. Experimental radioiodide therapy with 2 mCi (74 MBq) in thyroid-ablated nude mice, kept on a low-iodide diet, postponed tumor development (4 wk after therapy, one of seven animals revealed tumor vs. five of six animals without therapy). However, 9 wk after therapy, tumors had developed in four of the seven animals. The calculated tumor dose was 32.2 Gy. We conclude that hNIS transfection into a hNIS-defective thyroid carcinoma cell line restores the in vivo iodide accumulation. The unfavorable iodide kinetic characteristics (short half-life) can be partially improved by conventional conditioning with thyroid ablation and low-iodide diet, leading to postponed tumor development after radioiodide therapy. However, to achieve sufficient radioiodide tumor doses for therapy, further strategies are necessary, aiming at the mechanisms of iodide efflux in particular.

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ACTIVE SPECIES IN ZN-BUTYL IODIDE SYSTEM FOR COAL SOLUBILIZATION

Yubari coal treated with supernatant solution formed from a reaction of Bu2Zn and ZnI2 in the presence of butyl iodide shows 97 wt% of solubility in benzene, which is comparable with that obtained from one treated in a zinc-butyl iodide system. This result suggests that dibutylzinc, butylzinc iodide, and butyl iodide are indispensable species in the zinc-butyl iodide system for coal solubilization.

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Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 60166-93-0. Category: iodides-buliding-blocks.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 60166-93-0, Name is Iopamidol, molecular formula is C17H22I3N3O8, belongs to iodides-buliding-blocks compound. In a document, author is Ponpon, J. P., introduce the new discover, Category: iodides-buliding-blocks.

Etching of mercuric iodide in cation iodide solutions

The surface properties of mercuric iodide after etching in various cation iodide solutions have been investigated in terms of dissolution rate, morphology, electrical properties and reaction with water vapour. No significant differences have been observed in the etching rates. However, dissolution of HgI2 in NH4I, NaI, KI or RbI leaves the surface more or less covered with a residual iodo mercurate compound whose electrical properties and stability with regard to humidity may noticeably influence the behaviour of mercuric iodide devices. The smallest effect has been observed for etching in NaI. (c) 2005 Elsevier B.V. All rights reserved.

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The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 60166-93-0 is helpful to your research. Product Details of 60166-93-0.

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.60166-93-0, Name is Iopamidol, SMILES is O=C(C1=C(I)C(NC([C@@H](O)C)=O)=C(I)C(C(NC(CO)CO)=O)=C1I)NC(CO)CO, belongs to iodides-buliding-blocks compound. In a document, author is Keyvanfard, Mohsen, introduce the new discover, Product Details of 60166-93-0.

Kinetic catalytic-spectrophotometric determination of race amount of iodide

A new, simple, sensitive and selective catalytic spectrophotometric method was developed for the determination of ultra trace amounts of iodide. The method is based on the catalytic effect of iodide on the oxidation of Indigo carmin by iodate. The reaction was monitored spectrophotometrically by measuring the decrease in absorbance of Indigo carmin at 612 nm with a fixed-time method. The decrease in the absorbance of Indigo carmin is proportional to the concentration of iodide in concentration range 40.0-200.0 ng/ mL,with a fixed time of 0.5-2.5 min from initiation of the reaction. The limit of detection is 34 ng/mL iodide.The relative standard deviation of 0.060 and 0.10 mu g/mL iodide was 1.8 and 2.2%, respectively. The method was applied to the determination of iodide in water.

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Electric Literature of 60166-93-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 60166-93-0, Name is Iopamidol, SMILES is O=C(C1=C(I)C(NC([C@@H](O)C)=O)=C(I)C(C(NC(CO)CO)=O)=C1I)NC(CO)CO, belongs to iodides-buliding-blocks compound. In a article, author is LU, GH, introduce new discover of the category.

ANODIC-STRIPPING VOLTAMMETRY FOR THE DETERMINATION OF TRACE IODIDE

A carbon paste electrode is used for stripping voltammetry of trace iodide in a Britton-Robinson (B-R) buffer containing cetyltrimethyl ammonium bromide (CTMAB). The electrochemical behavior of I(2)BrR is described. In a solution containing 0.1 mu g/mL iodide, the relative standard deviation for ten determinations is 3.3%, the peak height also varies linearly with the concentration of iodide over the range 0.05-0.25 mu g/mL, and the detection limit is 0.03 mu g/mL. This method has been used for the determination of iodide in table salt samples with 88-104% recovery.

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Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 76801-93-9, Name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, molecular formula is C14H18I3N3O6, belongs to iodides-buliding-blocks compound, is a common compound. In a patnet, author is Wittebroodt, C., once mentioned the new application about 76801-93-9, Safety of 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide.

Influence of initial iodide concentration on the iodide uptake by the argillite of Tournemire

Among the radionuclides that can migrate from radioactive wastes buried within consolidated argillaceous rocks, I-129 poses a particular problem due to its high mobility in geomedia and its very long half-life of 1.6 10(7) years. Previous studies carried out on such rocks showed the existence of a low iodide retardation regarding the other anion species. The purpose of the present study was two-fold. It was hoped (1) to confirm this retardation by means of radial diffusion experiments and (2) to estimate the influence of the initial iodide concentrations towards the iodide uptake. The results obtained from in-diffusion stage show that (1) no iodide uptake occurs at high initial concentrations and (2) an uptake at low initial concentrations cannot be clearly evidenced. Finally. the most singular behaviour of iodide was highlighted for all the initial iodide concentrations, from the out-diffusion stage. during which some amount of iodide, available for out-diffusion, were not involved in the diffusion process. Although the origin of such phenomenon remains unclear, a kinetic effect for the iodide uptake was proposed, assuming that the period of 55days (corresponding to the in-diffusion stage duration) would be necessary for inducing the iodide uptake. This kinetic effect, already shown elsewhere by (Descostes. M., Blin, V., Bazer-Bachi, F., Meier, P., Grenut, B., Radwan. J., Schlegel, M.L., Buschaert, S.. Coelho, D, Tevissen, E. Diffusion of anionic species in Callovo-Oxfordian argillites and Oxfordian limestones. In press for Appl. Geochem.) on similar materials, needs to be deepened. (c) 2008 Elsevier Ltd. All rights reserved.

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Improved nickel-catalyzed cross-coupling reaction conditions between ortho-substituted aryl iodides/nonaflates and alkylzinc iodides in solution and in the solid-phase

ortho-Substituted aryl iodides and nonaflates undergo nickel-catalyzed cross-coupling reactions with functionalized alkylzinc iodides in the solid-phase as well as in solution providing high HPLC purities and good yields. (C) 2000 Elsevier Science Ltd. All rights reserved.

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HIGH-TEMPERATURE HEAT-CAPACITIES OF THALLIUM IODIDE, THULIUM IODIDE AND SODIUM-IODIDE BY DIFFERENTIAL SCANNING CALORIMETRY

The heat capacities of thallium iodide (alpha, beta and liquid phases), thulium iodide (crystal) and sodium iodide (crystal) have been determined by differential scanning calorimetry over the temperature range 370-800 K.

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Reference of 76801-93-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 76801-93-9.

Reference of 76801-93-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 76801-93-9, Name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, SMILES is O=C(NCC(O)CO)C1=C(I)C(N)=C(I)C(C(NCC(O)CO)=O)=C1I, belongs to iodides-buliding-blocks compound. In a article, author is Agretti, Patrizia, introduce new discover of the category.

In vitro effects of natural phytoestrogens on sodium/iodide symporter mediated thyroid iodide uptake by using a differentiated TSH-dependent cell line

Soy food health effects are due to isoflavone (ISF) components functioning as phytoestrogens similar to natural estrogen. Epidemiological data suggest a role of estrogens in pathogenesis of thyroid diseases explaining their prevalence in women. Aim of this study was to determine in vitro effects of isoflavones, soybean extract and Cimicifuga extract on iodide uptake, a crucial step in thyroid hormone biosynthesis, by using a differentiated TSH-dependent cell line (FRTL5). Estradiol didn’t influence iodide uptake and sodium-iodide symporter (NIS) mRNA expression in FRTL-5 cells. None of analyzed glycoside or aglycone isoflavone determined a significant inhibition of iodide uptake, while both isoflavone rich and triterpene rich extracts determined a significant reduction of iodide uptake at the higher doses. While soybean and Cimicifuga extracts inhibited iodide uptake at high doses, none of analyzed isoflavone exerted this effect. These elevated doses, however, are never reached in the blood following intake of food supplements.

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Reference of 60166-93-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 60166-93-0.

Reference of 60166-93-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 60166-93-0, Name is Iopamidol, SMILES is O=C(C1=C(I)C(NC([C@@H](O)C)=O)=C(I)C(C(NC(CO)CO)=O)=C1I)NC(CO)CO, belongs to iodides-buliding-blocks compound. In a article, author is Fornaro, L., introduce new discover of the category.

Synthesis of mercuric iodide and bismuth tri-iodide nanoparticles for heavy metal iodide films nucleation

We synthesized mercuric iodide and bismuth tri-iodide nanoparticles by suspension in octadecene, from Hg(NO3)2.H2O and I2, and from Bi(NO3)3.5H2O and I2, respectively. The best synthesis conditions were 2 h at 70-80 degrees C, followed by 10 min at 110 degrees C for mercuric iodide nanoparticles, and 4 h at 80-110 degrees C, followed by 10 min at 180-210 degrees C for bismuth tri-iodide ones. Nanoparticles were then washed and centrifuged with ether repeatedly. Compounds identity was confirmed by X-ray diffraction (XRD) and energy dispersive spectrometry (EDS). We found shifts of the X-ray diffraction maxima for nanoparticles of both compounds. We characterized the nanoparticles by transmission (TEM) and scanning (SEM) electron microscopy. We obtained disk-like and squared mercuric iodide nanostructures, 80-140 nm and 100-125 nm in size respectively. We also obtained rounded and rod-like bismuth tri-iodide nanoparticles, 30-500 nm in size. Acetonitrile and isopropanol suspensions of mercuric iodide nanoparticles, and acetonitrile suspension of bismuth tri-iodide nanoparticles exhibited peak maxima shifts in their UV-Vis spectra. We synthesized for the first time mercuric iodide and bismuth tri-iodide nanoparticles by the suspension method, although we have not yet obtained uniform shape and size distributions. They offer interesting perspectives for crystalline film nucleation and for improving current applications of these materials, as well as for opening new ones. (C) 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

Reference of 60166-93-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 60166-93-0.