Tag: M.W=700-800

76801-93-9, Name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, molecular formula is C14H18I3N3O6, belongs to iodides-buliding-blocks compound, is a common compound. In a patnet, author is Li, Huika, once mentioned the new application about 76801-93-9, Category: iodides-buliding-blocks.

Effect of iodide on human choriogonadotropin, sodium-iodide symporter expression, and iodide uptake in BeWo choriocarcinoma cells

Context: Active placental transport of maternal iodide by the thyroidal sodium iodide symporter ( NIS) provides an essential substrate for fetal thyroid hormone synthesis. NIS is expressed in trophoblast and is regulated by human choriogonadotropin ( hCG). In thyroid, iodide down- regulates expression of several genes including NIS. Placentas of iodine- deficient rats demonstrate up- regulation of NIS mRNA, suggesting a role for iodide in regulating placental NIS. Objectives and Methods: The objectives were to examine effects of iodide on expression of NIS and hCG in BeWo choriocarcinoma cells. Gene expression was studied by quantitative real- time PCR. Effects on NIS protein expression were assessed by Western blotting. Functional activity of NIS was measured by I-125 uptake. Expression of hCG protein was assessed by immunoassay of secreted hormone. Results: Iodide inhibited NIS mRNA and membrane protein expression as well as I-125 uptake, which were paralleled by decreased beta hCG mRNA expression and protein secretion. Iodide had no effects on pendrin expression. Addition of hCG increased NIS mRNA expression. This effect was partially inhibited by addition of iodide. The inhibitory effects of iodide on NIS mRNA expression were abolished by propylthiouracil and dithiothreitol. Conclusions: We conclude that expression of placental NIS is modulated by maternal iodide. This may occur through modulation of hCG effects on NIS and hCG gene expression.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 76801-93-9. The above is the message from the blog manager. Category: iodides-buliding-blocks.

Chemistry is an experimental science, Product Details of 60166-93-0, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 60166-93-0, Name is Iopamidol, molecular formula is C17H22I3N3O8, belongs to iodides-buliding-blocks compound. In a document, author is HUANG, TS.

IODIDE BINDING BY HUMIC-ACID

Iodide binding by humic acid was studied. The reaction was dose, temperature and pH dependent. A maximum binding of 88% was reached with 2 mg humic acid in 0.15 M Tris buffer. The efficiency of iodide binding by the buffer becomes higher whenever the buffer is slightly alkaline. Iodide binding by humic acid at 60-degrees-C is more efficient than that at room temperature or 4-degrees-C. The reaction was very rapid and reached equilibrium in 2 h. There are two binding sites for iodide in humic acid. The iodide binding by humic acid is inhibited by depletion of oxygen. The reaction was also inhibited by superoxide dismutase, catalase, thiourea, glutathione and dithiothreitol, but butylated hydroxytoluene and ascorbic acid did not inhibit it. In conclusion: (a) Humic acid can bind iodide efficiently in various buffers, (b) the binding is probably a reaction of oxidation reduction, (c) free radicals are involved in the reaction and (d) free radicals are present in the humic acid.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 60166-93-0, in my other articles. Product Details of 60166-93-0.

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Category: iodides-buliding-blocks, 76801-93-9, Name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, molecular formula is C14H18I3N3O6, belongs to iodides-buliding-blocks compound. In a document, author is KOH, T, introduce the new discover.

DETERMINATION OF MICRO-AMOUNTS OF IODIDE IN GEOTHERMAL WATER USING AN ION-SELECTIVE ELECTRODE

Iodide in various geothermal water samples was determined simply and rapidly with an iodide ion selective electrode. Two procedures were investigated for the determination of iodide. The first method is a direct method in which the iodide content in the geothermal water samples was directly measured with the iodide electrode after the addition of sodium hydrogen sulfite, a definite amount of iodide and ionic strength adjustment buffer. The other is a solvent extraction method in which iodide in the samples oxidized in advance by hydrogen peroxide was extracted into carbon tetrachloride. The iodide back-extracted into an aqueous sulfite solution was measured with the iodide electrode. Both procedures were successfully applied to the determination of iodide in the concentration below 1 ppm in various geothermal water samples with a relative standard deviation of 1.8%, and the results obtained by the proposed method were in good agreement with those by the spectrophotometric method using Methylene Blue.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 76801-93-9. Category: iodides-buliding-blocks.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 60166-93-0, Name is Iopamidol, SMILES is O=C(C1=C(I)C(NC([C@@H](O)C)=O)=C(I)C(C(NC(CO)CO)=O)=C1I)NC(CO)CO, belongs to iodides-buliding-blocks compound. In a document, author is Hutchinson, CM, introduce the new discover, Recommanded Product: Iopamidol.

Efficacy of methyl iodide and synergy with chloropicrin for control of fungi

Efficacy of soil fumigation with methyl bromide and methyl iodide against Botrytis cinerea, Colletotrichum gloeosporioides, Fusarium oxysporum, Gliocladium virens, Phytophthora citricola, Phytophthora citrophthora, Pythium ultimum, Rhizoctonia solani and Verticillium dahliae was determined in laboratory experiments in closed fumigation chambers. Pythium ultimum was the most sensitive fungal species with EC50 values for methyl bromide and methyl iodide of 15.5 and 8.6 mu M, respectively. R solani was the least sensitive with EC50 values of 253.4 and 161.4 mu M for methyl bromide and methyl iodide, respectively. Relative potency ([methyl bromide]/[methyl iodide]) values ranged from 5.2 for P citricola to 1.5 for F oxysporum. Methyl iodide was 2.7 more efficacious than methyl bromide averaged over all fungal species. Methyl bromide/chloropicrin and methyl iodide/chloropicrin applied jointly were 2.2 and 2.8 times more efficacious, respectively, against F oxysporum than when the compounds were applied singly. Combining methyl bromide and methyl iodide with chloropicrin resulted in a significant synergistic increase in activity against F oxysporum. (C) 2000 Society of Chemical Industry.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 60166-93-0 is helpful to your research. Recommanded Product: Iopamidol.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Computed Properties of C14H18I3N3O6, 76801-93-9, Name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, SMILES is O=C(NCC(O)CO)C1=C(I)C(N)=C(I)C(C(NCC(O)CO)=O)=C1I, in an article , author is Rillema, JA, once mentioned of 76801-93-9.

Characteristics of the prolactin stimulation of iodide uptake into mouse mammary gland explants

We have recently reported that prolactin (PRL) stimulates iodide uptake into cultured mouse mammary tissues, This effect occurs in both TCA soluble and insoluble tissue fractions, The effect of PRL apparently involves an RNA-DNA-dependent mechanism, since actinomycin D and cyclohexamide abolish the PRL stimulation of iodide uptake and its incorporation into protein, Perchlorate and thiocyanate, inhibitors of the iodide transporter, also abolish the PRL effects on iodide uptake and incorporation. Similarly, propylthiouracil and aminotriazole, inhibitors of peroxidase, abolish both effects of PRL, Finally, the extent of iodide uptake in mammary cells is suppressed by about 50% in sodium-free medium, These studies thus suggest the existence of a sodium-iodide symporter in the mammary gland which has characteristics similar to the iodide transporter in the thyroid gland-that is, It is sodium dependent and is inhibited by perchlorate and thiocyanate, The fact that both iodide transporter inhibitors and peroxidase inhibitors abolish PRL-stimulated iodide uptake and incorporation suggests that there may be a coupled mechanism involving the iodide transporter and the peroxidase enzyme.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 76801-93-9, you can contact me at any time and look forward to more communication. Computed Properties of C14H18I3N3O6.

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 76801-93-9, Name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide. In a document, author is Bhor, Malhari D., introducing its new discovery. Formula: C14H18I3N3O6.

Synthesis of alkyl iodides/nitriles from carbonyl compounds using novel ruthenium tris(2,2,6,6-tetramethyl-3,5-heptanedionate) as catalyst

Aldehydes and ketones were hydrogenated to the corresponding alcohols, which were then transformed in situ into their respective iodides and nitriles in good yields. A structurally well-defined O-containing transition metal complex, Ru (TMHD)(3), Was found to be the active catalyst for hydrogenation, inclination and cyanation reactions. It has high affinity for the transformation of benzylic alcohols to iodides and nitriles. (C) 2008 Elsevier Ltd. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 76801-93-9 help many people in the next few years. Formula: C14H18I3N3O6.

Application of 76801-93-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 76801-93-9, Name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, SMILES is O=C(NCC(O)CO)C1=C(I)C(N)=C(I)C(C(NCC(O)CO)=O)=C1I, belongs to iodides-buliding-blocks compound. In a article, author is MURAKAMI, S, introduce new discover of the category.

PROPRANOLOL HAS DIRECT ANTITHYROID ACTIVITY – INHIBITION OF IODIDE TRANSPORT IN CULTURED THYROID-FOLLICLES

The effect of propranolol on the process of thyroid hormone formation was studied in a physiological culture system. Porcine thyroid follicles were preincubated with propranolol for 24 h. Iodide transport, iodine organification, and de novo thyroid hormone formation were measured by incubating these follicles with the mixture of carrier-free 0.1 muCi (NaI)-I-125 and 50 nm NaI for 2 to 6 h at 37-degrees-C. A concentration of propranolol greater than 100 mum inhibited iodide transport in a dose-dependent manner; this inhibition was non-competitive with iodide and independent of thyrotropin (TSH). Reduced iodine organification and thyroid hormone formation was seen with 150 mum propranolol or greater. The inhibitory action of propranolol was not caused by beta-blocking activity, since D-propranolol (devoid of beta-blocking activity) inhibited iodide transport, and other beta-blockers (metoprolol, atenolol, and labetalol) did not inhibit iodide transport. The inhibition of iodide transport was most likely caused by membrane stabilizing activity since quinidine, which possesses the same membrane stabilizing activity as propranolol, also inhibited iodide transport. TSH-mediated cAMP generation and Na+K+ATPase activity, membrane functions for iodide transport, were unaffected by propranolol. Our study has shown, for the first time, that propranolol has a direct antithyroid action, namely inhibition of iodide transport in the intact thyroid follicle.

Application of 76801-93-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 76801-93-9.

Reference of 60166-93-0, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 60166-93-0, Name is Iopamidol, SMILES is O=C(C1=C(I)C(NC([C@@H](O)C)=O)=C(I)C(C(NC(CO)CO)=O)=C1I)NC(CO)CO, belongs to iodides-buliding-blocks compound. In a article, author is Um, W, introduce new discover of the category.

Linearity and reversibility of iodide adsorption on sediments from Hanford, Washington under water saturated conditions

A series of adsorption and desorption experiments were completed to determine the linearity and reversibility of iodide adsorption onto sediment at the Hanford Site in southeastern Washington. Adsorption experiments conducted with Hanford formation sediment and groundwater spiked with dissolved I-125 (as an analog tracer for I-129) indicated that iodide adsorption was very low (0.2 mL/g) at pH 7.5 and could be represented by a linear isotherm up to a total concentration of 100 mg/L dissolved iodide. The results of desorption experiments revealed that up to 60% of adsorbed iodide was readily desorbed after 14 days by iodide-free groundwater. Because iodide adsorption was considered to be partially reversible, even though small amount of initial iodide is retarded by adsorption at mineral-water interfaces, the weak adsorption affinity results in release of iodide when iodide-free pore waters and uncontaminated groundwaters contact the contaminated sediments in the vadose zone and aquifer systems. (C) 2004 Elsevier Ltd. All rights reserved.

Reference of 60166-93-0, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 60166-93-0 is helpful to your research.

Chemistry is an experimental science, Quality Control of Iopamidol, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 60166-93-0, Name is Iopamidol, molecular formula is C17H22I3N3O8, belongs to iodides-buliding-blocks compound. In a document, author is Fujiwara, H.

A novel V59E missense mutation in the sodium iodide symporter gene in a family with iodide transport defect

Iodide transport defect results from the malfunction of iodide transporter (sodium iodide symporter [NISI), and is characterized by low uptake of iodide into thyroid cells. Genetic analysis revealed that a T354P missense mutation causes iodide transport defect in the homozygous state and is a frequent mutation in the Japanese population. We recently reported three siblings with iodide transport defect harboring the T354P mutation in the heterozygous state. Here we report a novel V59E missense mutation associated with these siblings. The mutant protein showed low iodide transport activity.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 60166-93-0, in my other articles. Quality Control of Iopamidol.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 76801-93-9, Name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, molecular formula is C14H18I3N3O6. In an article, author is Nambu, Hisanori,once mentioned of 76801-93-9, SDS of cas: 76801-93-9.

Iodide-Catalyzed Ring-Opening Cyclization of Cyclohexane-1,3-dione-2-spirocyclopropanes

The ring-opening cyclization of 2′,3′-nonsubstituted and 2′-electron-withdrawing group (EWG)-substituted cyclohexane-1,3-dione-2-spirocyclopropanes was accomplished using iodide as a catalyst. The nonsubstituted derivatives afforded 3,5,6,7-tetrahydro-1-benzofuran-4(2H)-ones in high yields in the presence of trimethylsilyl iodide at room temperature. The EWG-substituted spirocyclopropanes, in turn, underwent regioselective ring opening followed by cyclization, which gave rise to 2-substituted tetrahydrobenzofuran-4-ones when a combination of tetrabutylammonium iodide catalyst and trifluoromethanesulfonic acid was used, whereas calcium iodide afforded the 3-substituted derivatives.

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