Synthetic Route of 199850-56-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 199850-56-1 name is Methyl 2-amino-4-chloro-5-iodobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution ofmethyl2-amino-4-chloro-5-iodobenzoate (3.4 g, 10.9 mmol) and imidoformamide (3.4 g, 32.7 mmol) in 2-methoxyethanol (15 mL) was stirred at 125C for 7 h. The reaction mixture was allowedto cool to rt and the residue suspended in water. The solid was collected by filtration,5 washed with water and dried under vacuum (50 C) to give 3.2 g of the title compound(96%). MS: m/z: 307 [M+H+]
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-amino-4-chloro-5-iodobenzoate, and friends who are interested can also refer to it.
Reference:
Patent; GLAXO GROUP LIMITED; BURY, Michael, Jonathan; CASILLAS, Linda, N.; CHARNLEY, Adam, Kenneth; DEMARTINO, Michael, P.; DONG, Xiaoyang; EIDAM, Patrick, M.; HAILE, Pamela, A.; MARQUIS, Robert, W., Jr.; RAMANJULU, Joshi, M.; ROMANO, Joseph, J.; SINGHAUS, Robert, R., Jr.; SHAH, Ami, Lakdawala; WANG, Gren; WO2013/25958; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com