Adding a certain compound to certain chemical reactions, such as: 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 51628-12-7, Recommanded Product: 2-(4-Iodophenyl)acetonitrile
(1) A three-necked flask was added with p-iodobenzeneacetonitrile (0.04 mol), phloroglucinol (0.02 mol) and etherAgent, zinc chloride (0.012 mol) as a catalyst, HCl gas (30 ml) was bubbled in an ice-salt bath for 1 hour to observe the reactionThe medium should change from colorless to orange. The reaction was allowed to stand in the freezer for 12 hours, and then continued to pass HCl gas (25ml)1 hour, standing in the refrigerator for 2 days, remove the reaction solution, decanting ether, water bath heated to reflux for two hours, was recrystallizedTo 2,4,6-trihydroxy-4′-iodo-phenylbenzyl ketone of general formula IIa.
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Reference:
Patent; Nanhua University; Zheng Xing; Zheng Qutong; Wang Zongbao; Lei Xiaoyong; Zeng Xianliang; Xiao Yan; Liu Ya; Huang Qiuxia; (23 pag.)CN106432165; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com