355-43-1, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane
General procedure: In a three-necked round flask, 9-decene-1-ol (5.0mmol) and perfluoroalkyl iodide (6.0mmol) were dissolved in a mixture of CH3CN and H2O (1:1, 10mL total). Sodium dithionate (Na2S2O4) (5.8mmol) and sodium hydrogen carbonate (NaHCO3) (5.2mmol) were added to the reaction mixture and the solution was stirred at room temperature for 4h. The reaction mixture was extracted with ethyl acetate and washed three times with water. The organic layer was dried over sodium sulfate (Na2SO4), filtered, and evaporated to yield 3a (2.433g, 96.9%) or 3b (2.786g, 92.6%) as yellow liquid.
The synthetic route of 355-43-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Miyajima, Hiroki; Kasuya, Maria Carmelita Z.; Hatanaka, Kenichi; Journal of Fluorine Chemistry; vol. 222-223; (2019); p. 24 – 30;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com