In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 1,1,1-Trifluoro-3-iodopropane
Example 25 (rac)-cis-9-(Phenylethynyl)-4-(3,3,3-trifluoropropyl)-3,4,4a,5,6,10b-hexahydro-2H-[1,4]oxazino[2,3-f]quinoline A mixture of cis-9-(phenylethynyl)-3,4,4a,5,6,10b-hexahydro-2H-[1,4]oxazino[2,3-f]quinoline (200 mg, 0.69 mmol), 1,1,1-trifluoro-3-iodopropane (202 mg, 0.90 mmol), and NaHCO3 (126 mg, 1.50 mmol) in DMF (3 mL) is stirred at 50-60 C for 6 hours. Then an additional amount of 1,1,1-trifluoro-3-iodopropane (100 mg, 0.45 mmol) is added, and the mixture is stirred at the same temperature for 16 h, cooled down to rt, diluted with water (50 mL) and extracted with EtOAc (2*50 mL). The combined organic layers are dried over Na2SO4 and concentrated at reduced pressure. The obtained residue is purified by column chromatography (silica gel, EtOAc/hexane, 1:2) to provide the title compound (75 mg, 28%) as a yellowish oil. 1H NMR (DMSO-d6), deltaH, 1.75-1.84 (m, 1H), 2.12-2.23 (m, 1H), 2.40-2.54 (m, 3H), 2.61-2.89 (m, 4H), 2.91-3.01 (m, 2H), 3.58-3.71 (m, 2H), 4.64 (d, 1H), 7.43-7.49 (m, 3H), 7.56-7.62 (m, 2H), 7.84 (d, 1H), 8.58 (d, 1H). LC/MS (M+H)+ = 387
The synthetic route of 460-37-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merz Pharma GmbH & Co. KGaA; The designation of the inventor has not yet been filed; EP2650284; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com