Some common heterocyclic compound, 5471-81-8, name is Methyl 4-iodo-3-methylbenzoate, molecular formula is C9H9IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: Methyl 4-iodo-3-methylbenzoate
Under a protective atmosphere of inert gas, Pd(OAc)2 (2.2 mg, 10 mol%), XPhos (19.1 mg, 20 mol%), NBE-CO2K (3.5 mg, were added to a 4.0 mL reaction flask equipped with a magnetic stir bar. 10 mol%), 3-methyl-4 iodine benzoate Methyl ester (0.2 mmol, 1.0 equiv.), N-(2,3-epoxypropyl)phthalamide (0.6 mmol, 3.0 equiv.) and dried Dry N-methylpyrrolidone (1.0 mL). The reaction flask was capped and stirred at room temperature for about 5 minutes, after which the mixture was added. Heat to 80 C for 24 hours. After cooling the reaction vessel to room temperature, it was quenched with water (10 mL) with methyl tert-butyl ether (3× 10 mL) was extracted, dried over Na2SO4, filtered and concentrated in vacuo. Purified by column chromatography, the eluent was petroleum ether: ethyl acetate = 2:1 (v/v),Obtained 42 mg of methyl 7-methyl-2-((1,3-dioxoisoindolin-2-yl)methyl)-2,3-dihydrobenzofuran-5-carboxylate (white solid, Yield 60%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5471-81-8, its application will become more common.
Reference:
Patent; Wuhan University; Zhou Qianghui; Wu Chenggui; Cheng Honggang; (20 pag.)CN108329285; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com