Reference of 51628-12-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 94 Synthesis of N-{2-[4-(3-(3-pyridyl)-4-methoxyphenyl)aminophenyl]ethyl}-(R)-2-hydroxy-2-(8-hydroxy-2(1H)-quinolinon-5-yl)ethylamine (94) Compound 94: Formula (XI) where R11 is 3-pyridyl a.Synthesis of 4-iodophenethylamine 4-Iodophenylacetonitrile (4.80 g, 19.7 mmol) was dissolved in tetrahydrofuran (25 ML) under nitrogen, and 1.0 M borane in tetrahydrofuran (29.6 ML, 29.6 mmol) was added via syringe.The reaction was heated at reflux for 1 hour, then cooled in ice and the excess borane was quenched by the addition of methanol (100 ML).When hydrogen evolution ceased, the solvents were removed under reduced pressure.The residue was dissolved in tetrahydrofuran (25 ML) and 4N HCl in dioxane (6.0 ML, 24 mmol) was added, followed by ether (75 ML).The hydrochloride salt of 4-iodophenethylamine was collected on a Buchner funnel, washed with ether (2*50 ML) and dried under reduced pressure.To generate the free base, the solid was partitioned between dichloromethane (200 ML) and 1N NaOH (100 ML).The aqueous layer was extracted with dichloromethane (2*100 ML).The combined organic layers were dried (Na2SO4) and concentrated to give 4-iodophenethylamine (4.52 g) as a colorless oil.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Iodophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Moran, Edmund J.; Jacobsen, John R.; Leadbetter, Michael R.; Nodwell, Matthew B.; Trapp, Sean G.; Aggen, James; Church, Timothy J.; US2003/229058; (2003); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com