Synthetic Route of 450412-28-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 450412-28-9, name is 1-Bromo-3-chloro-2-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Intermediate A1 (95.2 g, 0.29 mol),1-Bromo-3-chloro-2-iodobenzene (109.1 g, 0.34 mol),Copper Iododide (54.5 g, 0.29 mol) and K3PO4 (182.1 g, 0.86 mol) were placed in dimethylacetamide (950 mL) and the mixture was refluxed and stirred.After the reaction was completed, the reaction solution was cooled to room temperature and then copper was removed by filtration. The solution in which the product was dissolved was reduced in pressure to remove all of the solvent. Then, the solution was completely dissolved in CHCl 3 and washed with water. The solvent was then removed under reduced pressure, and the resulting product was purified by column chromatography to obtain 132.1 g of intermediate A2 (yield: 88% .
The synthetic route of 1-Bromo-3-chloro-2-iodobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LG Chem, Ltd.; Lee Jeong-ha; Park Tae-yun; Lee Dong-hun; Kim Min-jun; (39 pag.)KR2018/40100; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com