In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25245-27-6 as follows. Quality Control of 1-Iodo-3,5-dimethoxybenzene
Example 22B 3,5,3′-Trimethoxybiphenyl To a mixture of 600 mg (4.0 mmol) of 3-methoxyphenylboronic acid, 792 mg (3.0 mmol) of 3,5-dimethoxyiodobenzene, 34 mg (5 mol %) palladium(II)acetate, 182 mg (20 mol %) of tri-o-tolylphosphine, and 3.6 g (24 mmol) of cesium fluoride was added 10 mL of anhydrous dioxane. The reaction was stirred at reflux under N2 for 50 min, then poured into 30 mL of water and extracted with diethyl ether (3*10 mL). The combined ether layers were back extracted with saturated aqueous NaHCO3 solution (1*10 mL), then brine (1*10 mL), dried over MgSO4, filtered, and concentrated to an oil. This was purified via silica gel chromatography, eluding with 10% ethyl acetate:hexanes to provide the titled compound (650 mg, 89%).
According to the analysis of related databases, 25245-27-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Xin, Zhili; Liu, Gang; Pei, Zhonghua; Szczepankiewicz, Bruce G.; Serby, Michael D.; Zhao, Hongyu; US2004/167188; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com