Forschner-Dancause, Stephanie published the artcileQuorum sensing inhibition and structure-activity relationships of β-keto esters, Recommanded Product: Ethyl 3-(4-iodophenyl)-3-oxopropanoate, the main research area is keto ester structure quorum sensing inhibition; Vibrio harveyi; quorum sensing inhibition; β-keto esters.
A panel of 19 β-keto ester analogs was tested for the inhibition of bioluminescence (a quorum sensing-controlled phenotype) in the marine pathogen Vibrio harveyi. Initial screening demonstrated the need of a Ph ring at the C-3 position for antagonistic activity. Further additions to the Ph ring with 4-substituted halo groups or a 3- or 4-substituted methoxy group resulted in the most active compounds with IC50 values ranging 23-53μM. The compounds addnl. inhibit green fluorescent protein production by Escherichia coli JB525. Evidence is presented that aryl β-keto esters may act as antagonists of bacterial quorum sensing by competing with N-acyl homoserine lactones for receptor binding. Expansion of the β-keto ester panel will enable us to obtain more insight into the structure-activity relations needed to allow for the development of novel anti-virulence agents.
Molecules published new progress about Quorum sensing. 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Recommanded Product: Ethyl 3-(4-iodophenyl)-3-oxopropanoate.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com