One-pot synthesis of substituted dibenzoxazepinones and pyridobenzoxazepinones using octacarbonyldicobalt as an effective CO source was written by Anchan, Kavitha;Baburajan, Poongavanam;Puttappa, Nagaswarupa H.;Kumar Sarkar, Sujit. And the article was included in Synthetic Communications in 2020.Synthetic Route of C7H6FI This article mentions the following:
A facile one-pot protocol for the synthesis of substituted dibenzoxazepinones I (R = H, 2-F, 2-Me, 3-OMe; R1 = H, 7-Me, 8-Cl, 9-Me, etc.) and pyridobenzoxazepinones II (R2 = H, 3-Me, 2-Me; R3 = H, 8,9-Cl2, 9-Me, 8-Cl, 9-Cl) from com. available aryl/heteroaryl halides 2-X-R4C6H3X1 (R4 = H, 4-F, 4-Me, 4-OMe; X = F, Cl; X1 = I, Br)/III (X2 = F, Cl; R5 = H, 5-Me, 6-Me) and amino phenols 2-NH-3-R6-4-R7-5-R8C6HOH (R6 = H, Me; R7 = H, Cl, ; R8 = H, Cl, Me) using octacarbonyldicobalt (Co2(CO)8) as an effective metal carbonyl source has been demonstrated. This method proceeds via the sequential coupling of aryl/heteroaryl halides with aminophenol by amidation and intramol. cyclization to give dibenzoxazepinones I/pyridobenzoxazepinones II. In the experiment, the researchers used many compounds, for example, 1-Fluoro-2-iodo-4-methylbenzene (cas: 452-82-4Synthetic Route of C7H6FI).
1-Fluoro-2-iodo-4-methylbenzene (cas: 452-82-4) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Synthetic Route of C7H6FI
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com