The Palladium Slow-Release Pre-Catalysts and Nanoparticles in the “Phosphine-Free” Mizoroki-Heck and Suzuki-Miyaura Reactions was written by Sigeev, Alexander S.;Peregudov, Alexander S.;Cheprakov, Andrei V.;Beletskaya, Irina P.. And the article was included in Advanced Synthesis & Catalysis in 2015.Reference of 5460-32-2 This article mentions the following:
The Mizoroki-Heck reaction of electron-rich aryl iodides was studied using a phosphine-free catalytic system with a broad range of pre-catalysts of varied stability and structure based on organoselenium chelators. The application of the Hg test by observing the response of the catalytic systems studied not only to the addition, but also to the withdrawal of Hg allowed the authors to establish a critical role of nanoparticles in the operation of the phosphine-free catalytic systems. A three-stage mechanistic scheme involving a slow stage served by mononuclear Pd species, and the main fast stage served by Pd nanoparticles, and terminated by the nanoparticle decay is proposed as a general mechanistic paradigm for the phosphine-free Mizoroki-Heck and the related Suzuki-Miyaura reactions. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Reference of 5460-32-2).
4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Reference of 5460-32-2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com