Author: Jessica.F

Williams, A. C. published the artcileProduct class 4: benzopyranones and benzopyranthiones, Related Products of iodides-buliding-blocks, the publication is Science of Synthesis (2003), 347-638, database is CAplus.

A review. Methods for preparing 2H-1-benzopyran-2-ones, 4H-1-benzopyran-4-ones, 1H-2-benzopyran-1-ones, 6H-dibenzo[b,d]pyran-6-ones, 9H-xanthenones and their corresponding thione analogs as well as 3H-2-benzopyran-3-ones are surveyed. Synthetic methods include ring closure, ring transformation, aromatization and substituent modification reactions.

Science of Synthesis published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C7H8BClO2, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Brooke, G. M. published the artcileThe synthesis of oligomers related to poly(ethyleneglycol terephthalate), Related Products of iodides-buliding-blocks, the publication is Polymer (2001), 43(4), 1139-1154, database is CAplus.

Three end-capped oligomers 35, 41 and 45 related to poly(ethyleneglycol terephthalate) have been prepared starting from t-butylthioterephthalic acid 21 and its ethyleneglycol monoterephthalate derivative 25 terminally protected on the glycol moiety (by the tetrahydropyranyl group) and on the carboxylic acid moiety [by the 2-(2-pyridyl)-group].

Polymer published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Varinelli, Luca published the artcile4-IPP, a selective MIF inhibitor, causes mitotic catastrophe in thyroid carcinomas, Synthetic Route of 41270-96-6, the publication is Endocrine-Related Cancer (2015), 22(5), 759-775, database is CAplus and MEDLINE.

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that is over-expressed in several human neoplastic cells. When MIF binds its receptor (CD74) and co-receptor (CD44), it initiates signaling cascades that orchestrate cell proliferation and survival, and it can directly modulate the activity of AMPK. These activities indicate that MIF potentially regulates cell survival and metabolism We found that MIF was primarily co-expressed with CD74 in 16 out of 23 papillary thyroid carcinoma (PTC) and in all the 27 available anaplastic thyroid carcinoma (ATC) biopsy samples. MIF and CD74 were co-expressed in TPC-1 and HTC-C3 cell lines. The selective MIF inhibitor, 4-iodo-6-phenylpyrimidine (4-IPP), blocked MIF/CD74 internalization, activated JNK, and dose-dependently inhibited proliferation inducing apoptosis and mitotic cell death. In two CD74-neg. cell lines, NIM-1 and K1, 4-IPP treatment partially reduced proliferation. Coordinated MIF and CD74 expression appeared to confer in tumor cells the plasticity necessary to escape cell cycle regulation, metabolic changes, and stress conditions. MIF/CD74 signaling removal made cells susceptible to apoptosis and mitotic cell death. This finding suggests a possible avenue for targeting DNA endoreduplication, thus preventing the proliferation of therapy-resistant cell subpopulations. This study highlights MIF/CD74 axis as an important player in the biol. of aggressive thyroid neoplasms.

Endocrine-Related Cancer published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C8H15ClN2, Synthetic Route of 41270-96-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nino, Patricia published the artcileEfficient three-component synthesis of diversely substituted tetrahydro-1H-cyclopenta[c]quinolines, Synthetic Route of 364-12-5, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2016), 55B(7), 854-881, database is CAplus.

The synthesis of highly functionalized substituted tetrahydro-1H-cyclopenta[c]quinoline and its reduced derivatives hexahydro-1H-cyclopenta[c]quinolines via Povarov reaction in high diastereoselectivity and high to moderate yields is described. In addition, the relative stereochem. of the α-substituent to the tetrahydroquinoline nitrogen, as well as the regioselectivity of reaction, is shown to depend upon subtle substituent effects on the aldehyde and aniline precursors. In most cases, a preference for the formation of endo diastereomeric adducts is observed but for reactions with ortho-substituted aldehydes, the formation of exo adducts is also observed The exo-diastereoselectivity is found to be higher when the bulky size of this ortho group increases. Preparation of ortho and diortho-substituted aromatic aldehyde precursors of the Povarov reaction is also reported.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 364-12-5. 364-12-5 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Iodide,Benzene, name is 5-Bromo-2-iodobenzotrifluoride, and the molecular formula is C7H3BrF3I, Synthetic Route of 364-12-5.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Aladzheva, I. M. published the artcileSynthesis of N-(2-chloroethyl)glycine and –DL-alanine esters, Application of Ethyl 2-Iodopropionate, the publication is Russian Chemical Bulletin (2007), 56(12), 2456-2459, database is CAplus.

N-(2-chloroethyl)glycine and DL-alanine esters were prepared by reductive amination of the C=O group of glyoxilic or pyruvic acids upon treatment with 2-chloroethylamine and sodium cyanoborohydride in methanol and by alkylation of 2-chloroethylamine with α-haloalkanoic acid esters in K₂CO₃-MeCN two-phase system.

Russian Chemical Bulletin published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Application of Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Collis, Gavin E. published the artcileA modular procedure for the synthesis of functionalised β-substituted terthiophene monomers for conducting polymer applications, Recommanded Product: Pyridine Iodochloride complex, the publication is Tetrahedron (2007), 63(45), 11141-11152, database is CAplus.

An efficient modular strategy has been developed for the synthesis of β-functionalized terthiophene monomers using Suzuki-Miyaura and Wittig/Horner-Emmons chemistries. This paper discusses the problems encountered with converting the β-terthiophene aldehyde building block to the β-terthiophene phosphonium salt and the use of this material in a Wittig condensation. An improved strategy using the β-terthiophene phosphonate building block constructed via Suzuki-Miyaura coupling protocols was developed. We have synthesized and characterized a broad range of functionalized terthiophene materials that have been designed for specific end-use applications. The availability of these building blocks has dramatically increased access to a range of key monomers.

Tetrahedron published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Recommanded Product: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Trofymchuk, Serhii published the artcileDeoxofluorination of (Hetero)aromatic Acids, Name: 2-Chloro-4-iodobenzoic acid, the publication is Journal of Organic Chemistry (2020), 85(5), 3110-3124, database is CAplus and MEDLINE.

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines – valuable building blocks for medicinal chem. and agrochem. Of note, sulfur tetrafluoride (SF4) and hydrogen fluoride (HF) are toxic, therefore, safety and addnl. tech. training must be taken before working with them.

Journal of Organic Chemistry published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C13H18BClO2, Name: 2-Chloro-4-iodobenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rubenacker, Gerald V. published the artcileNitrogen-14 nuclear quadrupole resonance spectra of pyridine-halogen complexes, Recommanded Product: Pyridine Iodochloride complex, the publication is Inorganic Chemistry (1980), 19(2), 398-401, database is CAplus.

The ¹⁴N NQR spectra at 77 K are reported for adducts of pyridine with Cl₂, Br₂, I₂, ICN, ICl, IBr, BrCl, Br⁺, and I⁺. The data are interpreted in terms of a model for coordinated N based on the Townes-Dailey approximations The model yields estimates of the donor orbital occupancy, σ, for the N orbital directed toward the Lewis acid. The order of Lewis acid strengths based on relative σ values is ICN < I₂ < IBr < ICl < BrCl. The pyridine-Cl₂ complex appears to be ionic. The most reasonable formulation is [(py)Cl]Cl. Among the halogen cations the order of Lewis acidities is as expected: I⁺ < Br⁺ < Cl⁺.

Inorganic Chemistry published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Recommanded Product: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rubenacker, Gerald V. published the artcileNitrogen-14 nuclear quadrupole resonance spectra of coordinated pyridine. An extended evaluation of the coordinated nitrogen model, SDS of cas: 6443-90-9, the publication is Inorganic Chemistry (1980), 19(2), 392-8, database is CAplus.

The ¹⁴N NQR spectra at 77 K of several solid pyridine complexes with a wide range of Lewis acids were measured by a double-resonance method. The data are interpreted in terms of a coordinated N model, which permits an estimation of σ, the occupancy of the N donor orbital directed toward the Lewis acid. The values observed for σ in a series of pyridinium salts permit an ordering of the strength of H bonding to the anions: HSO₄^– â‰?NO₃^– > Cl^– > ClO₃^– > Br^– > ClO₄^–. The ¹⁴N NQR data correlate well with the NQR data for the H-bonded ²H in these compounds From comparisons of σ values it is possible to order the acidities of the Lewis acids as follows: Li⁺ < Ag⁺ < Cd²⁺ â‰?Mo(0) â‰?Cr(0) < Zn²⁺ â‰?Hg²⁺ âˆ?Fe(0) < BR₃ < BCl₃ < BBr₃ < SO₃ < H⁺ â‰?CH₃⁺. The relative positions in a few cases are uncertain because an insufficient number of complexes was studied to date.

Inorganic Chemistry published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, SDS of cas: 6443-90-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Piers, Edward published the artcileStereoselective total synthesis of copa and ylango sesquiterpenoids. Preparation of (-)-(1S,4S,5R,7R)-1,7-dimethyl-4-isopropylbicyclo[3.2.1]octa-6,8-dione and (+)-(1R,4S,5S,7S)-1,7-dimethyl-4-isopropylbicyclo[3.2.1]octa-6,8-dione, Synthetic Route of 31253-08-4, the publication is Canadian Journal of Chemistry (1975), 53(19), 2827-37, database is CAplus.

The efficient, stereoselective syntheses of 2 diastereomeric bicyclo[3.2.1]octadiones (I, II) are described and the potential use of these materials for the synthesis of the copa (III, R,R1 = O; R = H,R1 = OH, R = OH, R1 = H; IV, V and the ylango (VI,RR1 = O;R = H,R1 = OH;R = OH,R1 = H; VII,VIII) sesquiterpenoids, resp., is outlined. Conversion of (+)-carvomenthone (IX,Z = H2) into the corresponding n-butylthiomethylene derivative [IX,Z = CHS(CH2)3Me], followed by alkylation of the latter with EtO2CCHIMe, gave dione [X,R = Et,Z = CHS(CH2)3Me]. Removal of the blocking group from the latter was accompanied by ester hydrolysis and afforded keto acid (X,R = H,Z = H2). An efficient intramolecular Claisen condensation of the corresponding ester (X,R = Me,Z = H2) yielded (-)-(1S,4S,5R,7R)-1,7-dimethyl-4-isopropylbicyclo[3.2.1]octa-6,8-dione (I). Conversion of the known octalone XI (R = H,Z = H2) into the cross-conjugated keto aldehyde XII was accomplished by standard reactions. Treatment of the latter with LiCuMe2, followed by trapping of the resultant enolate anion with AcCl gave XI(R = Me,Z = CHOAc). Oxidative ozonolysis of this material yielded the keto acid XIII (R = H). Esterification of the latter, followed by intramol. Claisen condensation of the resulting keto ester XIII,R = Me, afforded (+)-(1R,4S,5S,7S)-1,7-dimethyl-4-isopropylbicyclo[3.2.1]octa-6,8-dione (II).

Canadian Journal of Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Synthetic Route of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com