Author: Jessica.F

Baker, Wilson published the artcilePreparation of iodine-containing x-ray contrast substances. I. 3,5-Diiodo-4-pyridone-N-acetic acid (“Perabrodil”), Application of 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, the publication is Journal of the Society of Chemical Industry, London (1943), 189-91, database is CAplus.

The synthesis of 3,5-diiodo-4-pyridone-1-acetic acid (I), m. 247°, used for the visulization of the urinary tract, was effected by the following steps: pyridine, containing 2% AlCl₃, in (CHCl₂)₂ was treated with 1 mol. Br at room temperature for 48 hrs., thus forming 4-pyridylpyridinium bromide-HBr, the aqueous solution of which, after freeing from (CHCl₂)₂, was hydrolyzed at 150° for 8 hrs., giving rise to a solution of pyridine-HBr and 4(1)-pyridone (II). This mixture was iodinated directly in aqueous NaOH by boiling with iodine and by making the solution alternately acid with concentrated HCl and alk. with 20% NaOH, 6 times during the course of 1 hr. The mechanism of the iodination is obscure; the product is 3,5-diiodo-4-pyridone (III) obtained, on final acidification and treatment with SO₂, as a cream-colored precipitate Moist III (250 g.) in warm aqueous NaOH (48 g. in 460 ml. H₂O) was heated with 60 g. CH₂ClCO₂H for 1 hr. and then treated with powd. NaCl. The separated Na salt of I yielded 107 g. I on acidification. I is polymorphous, crystallizing from H₂O in hexagonal plates, needles, or fernlike crystals.

Journal of the Society of Chemical Industry, London published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, Application of 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Poleshchuk, O. Kh. published the artcileHFI and DFT study of the bonding in complexes of halogen and interhalogen diatomics with Lewis base, Related Products of iodides-buliding-blocks, the publication is Journal of Molecular Structure: THEOCHEM (2006), 760(1-3), 175-182, database is CAplus.

We have analyzed by means of DFT calculations with use of the pseudo-potential the nuclear quadrupole coupling constants of a range of XY···B complexes (n aσ type in Mulliken notation) formed between diat. interhalogen mols. XY and Lewis bases B. The geometrical parameters, rotational and halogen nuclear quadrupole coupling constants obtained by these calculations substantially corresponded to the data of microwave spectroscopy in the gas phase. An anal. of the quality of the calculations that employ the pseudo-potential and the expanded basis set for the halogen compounds was carried out. The ZORA model is shown to be a viable alternative to the computationally demanding BH and HLYP model for the calculation of halogen and nitrogen coupling constants in mols. In addition, the ZORA model, in contrast to the pseudo-potential model, leads to realistic values of iodine nuclear quadrupole coupling constants From electron partitioning analyses and Klopman’s approach it follows that for the ICl···B complexes the electrostatic bonding is predominant relative to covalent bonding.

Journal of Molecular Structure: THEOCHEM published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Borisevich, A. N. published the artcileSynthesis and growth regulating effect of substituted 1-acylpyrazole, Computed Properties of 39115-95-2, the publication is Fiziologicheski Aktivnye Veshchestva (1977), 47-52, database is CAplus.

Of 13 title compounds I[R = Ph, C₆H₄O-p-Me, C₆H₄–p-Cl, C₆H₄–p-Br, C₆H₄–p-I, C₆H₄–p-NO₂, 3,4,5-(H₃CO)₃C₆H₃, Ph-p-NH₂, or NH₂; R¹ and R² = Me or NHPh; X = O or S], 0.0001% 1-p-bromobenzoyl-3-anilino-5-methylpyrazole [64808-38-4] and 0.001% 1-p-nitrobenzoyl-3-anilino-5-methylpyrazole [64808-42-0] stimulated the growth of lettuce and oats, resp.

Fiziologicheski Aktivnye Veshchestva published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Computed Properties of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bowmaker, Graham A. published the artcileAn SCF-MS-Xα study of the bonding and nuclear quadrupole coupling on 1:1 complexes of amines with diatomic halogens and interhalogens, Name: Pyridine Iodochloride complex, the publication is Journal of the Chemical Society, Faraday Transactions 2: Molecular and Chemical Physics (1987), 83(12), 2211-23, database is CAplus.

SCF-MS-Xα calculations of the electronic structure of the 1:1 complexes of pyridine with I₂, IBr, and ICl, and of the 1:1 trimethylamine-I₂ complex were carried out to investigate the bonding and nuclear quadrupole coupling in these mols. Good agreement (to within 10% in most cases) was obtained between the calculated and observed halogen nuclear quadrupole coupling constants for these mols. The agreement in the case of the nitrogen quadrupole coupling parameters was not as good, but the calculations do support some of the previously reported conclusions concerning the changes in the nitrogen orbital populations which occur upon complex formation. The results essentially support previous conclusions, based on analyses of the exptl. quadrupole coupling data by using the Townes-Dailey method, concerning the extent of charge transfer and the distribution of the transferred charge in these mols. They are, however, at variance with some of the results obtained from chem. shifts in the photoelectron spectra. The elec. dipole moments of the mols. were also calculated These are âˆ?0% higher than the highest reported exptl. values, but show the expected trends from one compound to another.

Journal of the Chemical Society, Faraday Transactions 2: Molecular and Chemical Physics published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Name: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Guillou, Sandrine published the artcileSimple preparations of 4 and 5-iodinated pyrazoles as useful building blocks, Recommanded Product: 4-Iodo-3-(trifluoromethyl)-1H-pyrazole, the publication is Tetrahedron (2011), 67(44), 8451-8457, database is CAplus.

The pyrazole nucleus has recently become a recurrent scaffold in the research fields of CropScience and oncol. We report here the preparation of an array of 4- and 5-iodinated pyrazole derivatives, such as 4-iodo-3-trifluoromethylpyrazole or Et 5-iodo-4-carboxy-3-trifluoromethylpyrazoles. This work provide access to many new pyrazole derivative, including eleven original out of sixteen iodinated building blocks, thus opening accesses to new chem. entities featuring a pyrazole nucleus.

Tetrahedron published new progress about 866638-72-4. 866638-72-4 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Pyrazole,Fluoride,Iodide, name is 4-Iodo-3-(trifluoromethyl)-1H-pyrazole, and the molecular formula is C4H2F3IN2, Recommanded Product: 4-Iodo-3-(trifluoromethyl)-1H-pyrazole.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Baillie, Sharon E. published the artcilePotassium-alkyl magnesiates: synthesis, structures and Mg-H exchange applications of aromatic and heterocyclic substrates, Safety of 4-Iodo-3-methoxypyridine, the publication is Chemical Communications (Cambridge, United Kingdom) (2014), 50(85), 12859-12862, database is CAplus and MEDLINE.

Using structurally well-defined dipotassium-tetra(alkyl)magnesiates, a new straightforward methodol. to promote regioselective Mg-H exchange reactions of a wide range of aromatic and heteroaromatic substrates is disclosed. E.g., reaction of anisole with (PMDETA)₂K₂Mg(CH₂SiMe₃)₂ in hexane at 20° followed by excess I₂ gave p-IC₆H₂OMe in 92% yield. Contacted ion pair intermediates probably are involved, with K being the key to facilitate the magnesiation processes.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1331850-50-0. 1331850-50-0 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Ether,Pyridine, name is 4-Iodo-3-methoxypyridine, and the molecular formula is C6H6INO, Safety of 4-Iodo-3-methoxypyridine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Arazi, Eden published the artcileA regulatory domain in the K_2P2.1 (TREK-1) carboxyl-terminal allows for channel activation by monoterpenes, Computed Properties of 41270-96-6, the publication is Molecular and Cellular Neuroscience (2020), 103496, database is CAplus and MEDLINE.

Potassium K_2P (leak) channels conduct current across the entire physiol. voltage range and carry leak or background currents that are, in part, time- and voltage-independent. K_2P2.1 channels (i.e., TREK-1, KCNK2) are highly expressed in excitable tissues, where they play a key role in the cellular mechanisms of neuroprotection, anesthesia, pain perception, and depression. Here, we report for the first time that human K_2P2.1 channel activity is regulated by monoterpenes (MTs). We found that cyclic, aromatic monoterpenes containing a phenol moiety, such as carvacrol, thymol and 4-IPP had the most profound effect on current flowing through the channel (up to a 6-fold increase). By performing sequential truncation of the carboxyl-terminal domain of the channel and testing the activity of several channel regulators, we identified two distinct regulatory domains within this portion of the protein. One domain, as previously reported, was needed for regulation by arachidonic acid, anionic phospholipids, and temperature changes. Within a second domain, a triple arginine residue motif (R344-346), an apparent PIP₂-binding site, was found to be essential for regulation by holding potential changes and important for regulation by monoterpenes.

Molecular and Cellular Neuroscience published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Computed Properties of 41270-96-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Blair, Victoria L. published the artcileAlkali-metal mediated zincation of N-heterocyclic substrates using the lithium zincate complex, (THF)Li(TMP)Zn(tBu)₂ and applications in in situ cross coupling reactions, Name: 4-Iodo-3-methoxypyridine, the publication is Tetrahedron Letters (2011), 52(36), 4590-4594, database is CAplus.

This study investigates the ability of the mixed-metal reagent [Li(TMP)Zn(tBu)₂] (I) to promote direct Zn-H exchange reactions (zincations) of a wide range of N-heterocyclic mols. The generated metalated intermediates from these reactions are intercepted with I₂ to yield iodoheterocycles, e.g. 3-iodo-2-methoxypyridine, and some of them are also employed as precursors in Pd-catalyzed Negishi cross-coupling applications yielding arylated N-heterocycles, e.g. 4-(4-chlorophenyl)-2-methoxypyridine. A comparison with recent precedents in metalation chem. reveals that for some of these heterocycles, I allows improved conversions, under milder conditions and in certain cases, even gives unique regioselectivities.

Tetrahedron Letters published new progress about 1331850-50-0. 1331850-50-0 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Ether,Pyridine, name is 4-Iodo-3-methoxypyridine, and the molecular formula is C6H6INO, Name: 4-Iodo-3-methoxypyridine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Levine, B. F. published the artcileCharge transfer complexes and hyperpolarizabilities, Product Details of C5H5ClIN, the publication is Journal of Chemical Physics (1977), 66(3), 1070-4, database is CAplus.

The 2nd-order β and 3rd-order γ hyperpolarizabilities of the 3 charge-transfer complexes pyridine + I2, pyridine + ICl, and 4-aminopyridine + I2 were measured. Mulliken’s charge-transfer theory was used to interpret theor. the large magnitude and absolute sign of these hyperpolarizabilities as well as their interesting and surprising dependence on the strength of the charge-transfer interaction.

Journal of Chemical Physics published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Product Details of C5H5ClIN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Musante, Carlo published the artcileSome salts and derivatives of 3,5-diiodo-4(1H)-pyridone-1-acetic acid, Synthetic Route of 101-29-1, the publication is Gazzetta Chimica Italiana (1948), 873-80, database is CAplus.

The work was prompted by the growing importance of derivatives of 3,5-diiodo-4(1H)-pyridone-1-acetic acid (I) in radiol. HC:CI.CO.CI:CH.NH (II) was purified by dissolving in a min. of N NaOH, heating at 100°, and repptg. by a current of CO₂. ClCH₂CONEt₂ (III) (4.5 g.), added slowly to 10.5 g. pure II in N NaOH, allowed to stand several hrs. (frequent agitation), and the precipitate purified by EtOH, yields 8.6 g. (62%) N,N-diethyl-3,5-diiodo-4(1H)-pyridone-1-acetamide, m. 231°. Pure HC:CBr.CO.CBr:CH.NH (IV) was prepared by allowing 5.56 g. pyridone in 40 cc. AcOH and 9.3 g. Br to stand 5 h., diluting with water, dissolving the precipitate in N NaOH, and repptg. by CO₂. III (4 g.), added slowly to 5 g. IV, allowed to stand several hrs., and the precipitate purified by EtOH, yields approx. 5 g. 3,5-dibromo-N,N-diethyl-4(1H)-pyridoneacetamide, m. 224-5°. II (4.4 g.) in 20 cc. N NaOH agitated with 2.5 cc. Me₂SO₄, heated to 100°, allowed to stand 30 min., and the precipitate purified by water, yields 4 g. HC:CI.CO.CI:CH.NMe (V). Aqueous KMnO₄ (400 cc. of 1%) added slowly to aqueous V (1 g. in 180 cc.), and the mixture steam-distilled, yields CHI₃; the residue, filtered and concentrated, yields a solution containing an iodide (indicated by acidification with H₂SO₄ and addition of CHCl₃ and Cl water). In contrast to this, II is not oxidized by KMnO₄ under the same conditions. However, boiling II and aqueous KMnO₄ several hrs. yield a little iodide and (CO₂H)₂. I (2 g.) and 15 cc. SOCl₂, refluxed 2 h. (the solution turns red, then colorless), distilled, and the residue taken up in Et₂O, dissolved in aqueous NaOH, and reprecipitated by CO₂, yield II. Salts of I were prepared from alc. I and aqueous solutions of salts of the metals concerned. They are probably of normal electrovalent structure, of low solubility in water and organic solvents, and melt at high temperatures, with decomposition Salts: Ag, from AgNO₃ (100% yield), m. 297°, turns brown in light; Pb, from acidic Pb(OAc)₂, m. approx. 300°; Cd, from Cd(OAc)₂, lustrous, m. 286°; mercuric, from Hg(OAc)₂, m. 253°; cupric, from Cu(OAc)₂, blue-green, m. 257°; Zn, from Zn(OAc)₂, m. 285°; Co, from Co(NO₃)₂ buffered by NaOAc, rose color, turns brown at 200°, violet at 240°, blackish at 270°, and m. 295°; Ni, from Ni(OAc)₂, light green (no m.p. given); ferric, from FeCl₃, ocher-yellow, turns almost black 270°, m. 290°; La, from boiling aqueous LaCl₃, turns brown approx. 270°, decompose around 300°, solubility in water 3.33 × 10^-4 g.-mol./l. at 20°; Pr, from PrCl₃, turns brown around 280-5°, decompose around 300°; Nd, from boiling aqueous (PhS)₃Nd, begins to decompose 285°, decompose completely 300°; Sm, from boiling aqueous (PhS)₃Sm, decompose around 300°; Gd, from boiling aqueous (PhSO₃)₃Gd, decompose around 300°, solubility in water 3.33 × 10^-4 g.-mol./l. at 20°. Pb 3,5-dibromo-4(1H)-pyridone-1-acetate, (C₇H₄O₃NBr₂)₂Pb, from Pb(OAc)₂ and HC:CBr.CO.CBr:CH.NCH₂CO₂H, no m.p. given.

Gazzetta Chimica Italiana published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, Synthetic Route of 101-29-1.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com