Author: Jessica.F

Lammert, Martin published the artcileSingle- and Mixed-Linker Cr-MIL-101 Derivatives: A High-Throughput Investigation, Product Details of C10H9IO4, the publication is Inorganic Chemistry (2013), 52(15), 8521-8528, database is CAplus and MEDLINE.

New single- and mixed-linker Cr-MIL-101 derivatives bearing different functional groups were synthesized. The influence of the reaction parameters, such as metal source (CrO₃, CrCl₃, and Cr(NO₃)₃·9H₂O) or linker composition, on product formation were studied using high-throughput methods. Highly crystalline Cr-MIL-101 materials were obtained with CrCl₃ as the metal source with either 2-bromoterephthalic (TA-Br) or 2-nitroterephthalic (TA-NO₂) acid as one of the mixed-linker components. Numerous new mixed-linker Cr-MIL-101 derivatives containing -NH₂, -NO₂, -H, -SO₃H, -Br, -OH, -CH₃, and -COOH were synthesized. The use of TA-NH₂ and TA-OH were shown, under the same reaction conditions, to lead to decarboxylation and the formation of 3-amino- and 3-hydroxybenzoic acid, resp. Also, the authors were also able to directly synthesize single-linker Cr-MIL-101-X derivatives with X = F, Cl, Br, CH₃. Postsynthetic modification was used to selectively reduce the mixed-linker compound Cr-MIL-101-Br-NO₂ to Cr-MIL-101-Br-NH₂. To establish the successful incorporation of the linker mols. and possible decomposition of certain starting materials, ¹H NMR spectra of dissolved reaction products were recorded.

Inorganic Chemistry published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Product Details of C10H9IO4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hedidi, Madani published the artcileDeprotometalation of substituted pyridines and regioselectivity-computed CH acidity relationships, Quality Control of 1331850-50-0, the publication is Tetrahedron (2016), 72(17), 2196-2205, database is CAplus.

A series of methoxy- and fluoro-pyridines have been deprotometalated in THF at room temperature by using a mixed lithium-zinc combination obtained from ZnCl₂·TMEDA (TMEDA=N,N,N’,N’-tetramethylethylenediamine) and LiTMP (TMP=2,2,6,6-tetramethylpiperidino) in a 1:3 ratio, and the metalated species intercepted by iodine. Efficient functionalization at the 3 position was observed from 4-methoxy, 2-methoxy, 2,6-dimethoxy, 2-fluoro and 2,6-difluoropyridine, and at the 4 position from 3-methoxy and 2,3-dimethoxypyridine. Interestingly, clean dideprotonation was noted from 3-fluoropyridine (at C2 and C4) and 2,6-difluoropyridine (at C3 and C5). The obtained regioselectivities have been discussed in light of the CH acidities of the substrates, determined both in the gas phase (DFT B3LYP and G3MP2B3 levels) and in THF solution In the case of methoxypyridines, the pK_a values have also been calculated for complexes with LiCl and LiTMP.

Tetrahedron published new progress about 1331850-50-0. 1331850-50-0 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Ether,Pyridine, name is 4-Iodo-3-methoxypyridine, and the molecular formula is C6H6INO, Quality Control of 1331850-50-0.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ivan, nathaniel published the artcileSynthesis of new boronated and phosphonated aromatic flame retardants, Computed Properties of 165534-79-2, the publication is PMSE Preprints (2012), No pp. given, database is CAplus.

We have focused on the use of catalytic processes to add boron and phosphorus based groups to aromatic compounds such as terephthalates and phenols. This has been done since these compounds could in turn act as reactive flame retardants which could address some of the environmental/leaching issues that affect flame retardant materials.

PMSE Preprints published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Computed Properties of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ivan, Nathaniel published the artcilePreparation of phosphonoterephthalic acids via palladium-catalyzed coupling of aromatic iodoesters, Computed Properties of 165534-79-2, the publication is Synthetic Communications (2013), 43(13), 1831-1836, database is CAplus.

The current article reported in detail the preparation of two phosphonoterephthalic acids: 2-phosphonoterephthalic acid and 2,5-diphosphonoterephthalic acid. Efficient, scalable syntheses were developed for both compounds based on Pd-catalyzed coupling reactions of iodinated terephthalate esters. Phosphonoterephthalic acids are potentially useful as flame-retardant additives or as monomers for the construction of acid-pendant polymer chains.

Synthetic Communications published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Computed Properties of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Alabaster, Colin T. published the artcile2(1H)-Quinolinones with cardiac stimulant activity. 1. Synthesis and biological activities of (six-membered heteroaryl)-substituted derivatives, Recommanded Product: (2-Amino-5-iodophenyl)methanol, the publication is Journal of Medicinal Chemistry (1988), 31(10), 2048-56, database is CAplus and MEDLINE.

A series of (six-membered heteroaryl)-substituted 2(1H)-quinolinones, e.g., I (R = H, R¹ = pyridin-2-yl), were synthesized, and structure-activity relationships for cardiac stimulant activity were determined Most compounds were prepared by acidic hydrolysis of a heteroaryl-2-methoxyquinoline obtained by palladium-catalyzed cross-coupling methodol. Direct reaction of a pyridinylzinc reagent with a 6-haloquinolinone also proved successful. In anesthetized dogs, I (R = H, R¹ = pyridin-3-yl)(II) (50 μg/kg) displayed greater inotropic activity (percentage increase in dP/dt max) than positional isomers, and potency was maintained with either mono- or di- alkylpyridinyl substituents. Introduction of a 4- or 7-Me group into II reduced inotropic activity, whereas the 8-isomer I (R = Me, R¹ = pyridin-3-yl)(III) proved to be the most potent member of the series. III and the 2,6-dimethylpyridinyl analog I (R = Me, R¹ = 2,6-dimethylpyridin-3-yl)(IV) were approx. 6 and 3 times, resp., more potent than milrinone. Several quinolinones displayed pos. inotropic activity (decrease in QA interval) in conscious dogs after oral administration (1 mg/kg), and III and IV were again the most potent members of the series. IV (0.25, 0.5, 1.0 mg/kg po) demonstrated dose-related cardiac stimulant activity, which was maintained for at least 4 h. No changes in heart rate were observed Compounds II, III, IV, and I (R = H, R¹ = pyridin-4-yl) also selectively stimulated the force of contraction, rather than heart rate, in the dog heart-lung preparation For a 50% increase in dP/dt max with IV, heart rate changed by less than 10 beats/min. In norepinephrine contracted rabbit femoral artery and saphenous vein, IV produced dose related (5 × 10^-7 to 5 × 10^-4 M) vasorelaxant activity. The combined cardiac stimulant and vasodilator properties displayed by IV, coupled with a lack of effect on heart rate, should be beneficial for the treatment of congestive heart failure.

Journal of Medicinal Chemistry published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Recommanded Product: (2-Amino-5-iodophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Aloisi, Giangaetano published the artcileCharge transfer complexes between halogens and pyridines. 4. Effect of the acid strength of the acceptors, Quality Control of 6443-90-9, the publication is Transactions of the Faraday Society (1970), 66(12), 3075-80, database is CAplus.

Charge-transfer equilibrium between Br, I, ICl, and IBr as acceptors and various meta- and para-substituted pyridines as donors were studied spectrophotometrically in CCl4 at 30°. Formation constant of the complexes were correlated with Hammett’s substituent constant, ionization constant of the donors, and acid strength of the acceptors. Correlations with intermol. and(or) interhalogen spectral parameters are also discussed.

Transactions of the Faraday Society published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Quality Control of 6443-90-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Munchhof, Michael J. published the artcileDesign and SAR of thienopyrimidine and thienopyridine inhibitors of VEGFR-2 kinase activity, Related Products of iodides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2004), 14(1), 21-24, database is CAplus and MEDLINE.

Novel classes of thienopyrimidines and thienopyridines have been identified as potent inhibitors of VEGFR-2 kinase. The synthesis and structure-activity relationship of these compounds is presented, along with successful efforts to diminish EGFR activity present in the lead series. The presence of a 2-Me substituent in the indole moiety in the [(2-methyl-1H-indol-5-yl)amino]thieno[3,2-b]pyridine series [I, R = CH₂N(Me)(CH₂)₂OH, CH₂NH(CH₂)₃OH, CH₂NH(CH₂)₂O(CH₂)₂OH, CH₂NH(CH₂)₂OH, etc., R¹ = Me] was found to decrease EGFR activity more than 100-fold, while having little effect on VEGFR activity, when compared to [(1H-indol-5-yl)amino]thieno[3,2-b]pyridines I (same R, R¹ = H).

Bioorganic & Medicinal Chemistry Letters published new progress about 602303-26-4. 602303-26-4 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Iodide, name is 7-Chloro-2-iodothieno[3,2-b]pyridine, and the molecular formula is C7H3ClINS, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lunzer, Markus published the artcileBeyond the Threshold: A Study of Chalcogenophene-Based Two-Photon Initiators, Formula: C6H13I, the publication is Chemistry of Materials (2022), 34(7), 3042-3052, database is CAplus and MEDLINE.

A series of nine soluble, sym. chalcogenophenes bearing hexyl-substituted triphenylamines, indolocarbazoles, or phenylcarbazoles was designed and synthesized as potential two-photon absorption (2PA) initiators. A detailed photophys. anal. of these mols. revealed good 2PA properties of the series and, in particular, a strong influence of selenium on the 2PA cross sections, rendering these materials especially promising new 2PA photoinitiators. Structuring and threshold tests proved the efficiency and broad spectral versatility of two selenium-containing lead compounds as well as their applicability in an acrylate resin formulation. A comparison with com. photoinitiators Irg369 and BAPO as well as sensitizer ITX showed that the newly designed selenium-based materials TPA-S and TPA-BBS outperform these traditional initiators by far both in terms of reactivity and dose. Moreover, by increasing the ultralow concentration of TPA-BBS, a further reduction of the polymerization threshold can be achieved, revealing the great potential of this series for application in two-photon polymerization (2PP) systems where only low laser power is available.

Chemistry of Materials published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lima, Eurico published the artcilePicolylamine-functionalized benz[e]indole squaraine dyes: Synthetic approach, characterization and in vitro efficacy as potential anticancer phototherapeutic agents, Application of 1-Iodohexane, the publication is European Journal of Medicinal Chemistry (2022), 114071, database is CAplus and MEDLINE.

Squaraine dyes are a family of compounds known for their relevant photophys. and photochem. properties potentially useful as photosensitizing agents. Since pyridines have been introduced into the skeleton of several families of compounds to enhance their pharmacol. activity, and this approach had not yet been performed on squaraines, novel dyes derived from benz[e]indole functionalized with picolyl- and dipicolylamine and N-Et and -hexyl chains were designed and synthesized. After being fully characterized, their interaction with human albumin was in vitro and in silico evaluated. Dyes were further assessed for their phototoxicity activity, and the most interesting ones were studied regarding cell localization and induction of morphol. cell changes, genotoxicity, apoptosis and cell cycle arrest. The mols. with N-Et chains showed the greatest in vitro light-dependent cytotoxic effects, particularly the zwitterionic squaraine dye and the one bearing a single pyridine unit, which also exhibited a more significant interaction with human albumin. Phenotypically, the cells incubated with these squaraines became smaller and rounded after irradiation, the effects varying with the tested concentration Genotoxic effects were observed even without irradiation, being more evident for the N-Et picolylamine-derived dye. The fluorescence emitted by Rhodamine 123 largely coincided with that emitted by the dyes, suggesting that they are found preferentially in mitochondria. After irradiation, an increase in the subG1 population was verified by propidium iodide-staining anal. by flow cytometry, indicative of cell death by apoptosis.

European Journal of Medicinal Chemistry published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Application of 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mason, Stephen J. published the artcileSolid-phase catch, activate, and release synthesis of cyanine dyes, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Organic Letters (2002), 4(24), 4261-4264, database is CAplus and MEDLINE.

Trimethine cyanine dyes were synthesized by capture and activation of a hemicyanine intermediate on a sulfonyl chloride resin followed by reaction and concomitant cleavage by a heterocyclic carbon nucleophile. A small array of dyes was synthesized and characterized to demonstrate the versatility of this chem. for a number of hemicyanines and heterocyclic nucleophiles.

Organic Letters published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com