Category: iodides-buliding-blocks

Chaikovskii, V. K. published the artcileIodination of aromatic compounds with iodine monochloride in aqueous sulfuric acid, Application In Synthesis of 2100-25-6, the main research area is iodination aromatic compound iodine chloride; toluene iodination iodine chloride; chemoselectivity iodination aromatic compound iodine chloride; regioselectivity iodination aromatic compound iodine chloride; alkylbenzene iodination iodine chloride; durene iodination iodine chloride; anisole iodination iodine chloride; aniline iodination iodine chloride.

Iodine monochloride in aqueous sulfuric acid turned out to be a convenient and general reagent for preparative iodination of alkylbenzenes, phenol ethers, and aromatic amines. The relative selectivity and activity of iodine monochloride in aqueous solutions of sulfuric acid with various concentrations were determined using toluene as model substrate. Raising the sulfuric acid concentration results in considerable increase of the electrophilicity of ICI. Effective sulfuric acid concentrations were determined for specific substrate series. Iodine monochloride in aqueous sulfuric acid shows enhanced selectivity in the synthesis of monoiodo derivatives

Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Application In Synthesis of 2100-25-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kodomari, Mitsuo published the artcileDirect iodination of aromatic compounds with iodine and alumina-supported copper(II) chloride or sulfate, Category: iodides-buliding-blocks, the main research area is iodination aromatic compound iodine; copper chloride sulfate iodination aromatic compound; alumina copper chloride iodination aromatic compound.

The iodination of aromatic compounds (polymethylbenzenes, alkyl Ph ethers, and polynuclear aromatic hydrocarbons) with iodine in combination with copper(II) chloride or sulfate supported on alumina proceeds well under mild conditions to selectively give monoiodinated compounds in high yields.

Bulletin of the Chemical Society of Japan published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Category: iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Galli, Carlo published the artcileAromatic iodination: evidence of reaction intermediate and of the σ-complex character of the transition state, Related Products of iodides-buliding-blocks, the main research area is aromatic iodination mechanism reaction intermediate; transition state aromatic iodination.

The reactivity of four different procedures of aromatic iodination is compared under the same exptl. conditions, and their selectivity toward two substrates in competition, i.e., mesitylene (I) and durene (II), is evaluated. Two of these procedures, namely, S2O82-/I2 and CeIV/I2, present strong oxidizing capacity. Since the same I/II relative reactivity is obtained from the four procedures, it becomes possible to state that a common reactive intermediate, most likely the I+ ion, is generated. The use of the I/II mechanistic probe suggests the following description of the iodination reaction: electrophilic substitution at the aromatic nucleus, with a transition state properly represented in terms of a σ-complex. The radical cation of II also forms when the iodination is carried out by means of oxidizing agents, but it is solely responsible for the formation of side-chain substitution products and is not involved in the nuclear substitution process.

Journal of Organic Chemistry published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Related Products of iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dong, Ziyang published the artcileDual roles of bisphosphines and epoxides: Rh-catalyzed highly chemoselective and diastereoselective (3 + 2) transannulations of 1,2,3-thiadiazoles with cyanoepoxides, Recommanded Product: Ethyl 3-(4-iodophenyl)-3-oxopropanoate, the main research area is cyanoepoxide thiadiaazole rhodium catalyst chemoselective diastereoselective regioselective cycloaddition; oxiranyl isothiazole preparation.

A highly diastereoselective and chemoselective (3 + 2) transannulation of 1,2,3-thiadiazoles with cyanoepoxides was discovered. The use of sterically larger DPEPhos allows the preparation of cis-epoxyl isothiazoles from cis-cyanoepoxides in up to 95% yields and 100 : 0 dr, while the use of sterically smaller DPPF allows the synthesis of trans-products from cis- or trans-cyanoepoxides in up to 95% yields and 100 : 0 dr. Bisphosphines and epoxides play dual roles. Bisphosphines served not only as ligands, but also as catalysts to catalyze the isomerization of cis-epoxides to trans-isomers. The diastereoselectivity was controlled by the kinetic competition between the direct transannulation of cis-cyanoepoxides and the bisphosphine-catalyzed isomerization of cis-products. The epoxy group’s large steric hindrance guarantees excellent chemoselectivity toward the (3 + 2) annulation, and its electron-withdrawing ability significantly improves the reactivity of the adjacent cyano group. To address the controversy over the organorhodium intermediates, this study suggested the resonation between Lee’s umpolung 1,3-dipoles, Bao’s cyclometalated Rh(III) complexes, and thioacyl-coordinated Rh(I) carbenes. Stereospecific access to isothiazole-fused γ-lactone was also developed.

Organic Chemistry Frontiers published new progress about [3+2] Cycloaddition reaction catalysts (chemo and stereoselective). 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Recommanded Product: Ethyl 3-(4-iodophenyl)-3-oxopropanoate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

McKillop, Alexander published the artcileFurther functional-group oxidations using sodium perborate, Recommanded Product: 3-Iodo-1,2,4,5-tetramethylbenzene, the main research area is sodium perborate oxidant; aldehyde oxidation sodium perborate; iodoarene oxidation sodium perborate; nitrile aromatic oxidation hydration; azine oxidation sodium perborate; sulfur heterocycle oxidation sodium perborate.

Sodium perborate in acetic acid is an effective reagent for the oxidation of aromatic aldehydes to carboxylic acids, iodoarenes to (diacetoxyiodo)arenes, azines to N-oxides, and various types of sulfur heterocycles to S,S-dioxides. Nitriles are unaffected by the reagent in acetic acid, but undergo smooth hydration to amides when aqueous methanol is employed as solvent.

Tetrahedron published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Recommanded Product: 3-Iodo-1,2,4,5-tetramethylbenzene.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yang, Han published the artcileSynthesis of 2-Aryl Azetidines through Pd-Catalyzed Migration/Coupling of 3-Iodoazetidines and Aryl Boronic Acids, Application In Synthesis of 939759-26-9, the main research area is aryl azetidine preparation regioselective; iodoazetidine boronic acid migration cross coupling reaction palladium.

A palladium-catalyzed cross-coupling of 3-iodoazetidines and nonheteroaryl boronic acids was reported. The [1,1′-biphenyl]-2-yldicyclohexylphosphane ligand enabled the reaction that favored the formation of 2-aryl azetidines. The control experiments indicated that the reaction can proceed through either a palladium-hydride/dihydroazete complex or free dihydroazete intermediate followed by hydropalladation.

Organic Letters published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, Application In Synthesis of 939759-26-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Muathen, Hussni A. published the artcileMild and efficient iodination of aromatic compounds with pyridine-iodine monochloride complex (PylCl), Application of 4-Iodo-2-nitrophenol, the main research area is aromatic hydrocarbon iodination; benzene iodination pyridine iodine monochloride complex.

A wide range of aromatic compounds (e.g., C6H6) have been effectively iodinated with a pyridine-iodine monochloride complex (I). Condensed polycyclic iodides, which are not readily obtained via direct iodination, can be prepared indirectly via their corresponding organomercurials in 1 step. Some benzoid and nonbenzoid heterocycles (e.g., indole) are iodinated with I.

Journal of Chemical Research, Synopses published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Application of 4-Iodo-2-nitrophenol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sumi Mitra, S. published the artcilePolymer-bound benzyltriethylammonium polyhalides: recyclable reagents for the selective iodination of amines and phenols, Formula: C6H5IN2O2, the main research area is polymer bound benzyltriethylammonium halide iodination agent; phenol iodination polymer bound benzyltriethylammonium halide; amine iodination polymer bound benzyltriethylammonium halide.

Polymer-bound benzyltriethylammonium dichloroiodate, tetrachloroiodate, and dibromoiodate reagents were developed as new recyclable solid-phase reagents. The use of these polymeric polyhalides for the iodination of activated benzene and naphthalene derivatives such as amines and phenols is described. The spent reagents after the synthetic reactions were easily removed by filtration and were regenerated for further use. The efficiency of these reagents towards mono-selectivity in aromatic iodination and the variation of reactivity of the iodinating reagents as a function of the nature of solvent, effective molar concentration and temperature were investigated.

Reactive & Functional Polymers published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Formula: C6H5IN2O2.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Awad, Hacan published the artcileDeprotonation of fluoro aromatics using lithium magnesates, Recommanded Product: 2,6-Difluoro-3-iodopyridine, the main research area is deprotonation fluoro aromatic lithium magnesate.

3-Fluoropyridine was deprotonated on treatment with 1/3 equiv of Bu3MgLi in THF at -10 °C. The lithium arylmagnesate formed was either trapped with electrophiles or involved in a palladium-catalyzed cross-coupling reaction with 2-bromopyridine. The use of a less nucleophilic lithium-magnesium-dialkylamide, (TMP)3MgLi (TMP = 2,2,6,6-tetramethylpiperidino) allowed the reaction of 3-fluoroquinoline, giving the 2,2′-dimeric derivative 2-Fluoropyridine and 2,6-difluoropyridine were deprotonated using 1/3 equiv of the highly coordinated magnesate Bu4MgLi2 in THF at -10 °C in the presence of a substoichiometric amount of 2,2,6,6-tetramethylpiperidine. 1,3-Difluorobenzene reacted similarly when treated with Bu3MgLi; the reactivity of the base proved to be enhanced by the presence of TMEDA.

Tetrahedron Letters published new progress about Aryl fluorides Role: RCT (Reactant), RACT (Reactant or Reagent). 685517-67-3 belongs to class iodides-buliding-blocks, name is 2,6-Difluoro-3-iodopyridine, and the molecular formula is C5H2F2IN, Recommanded Product: 2,6-Difluoro-3-iodopyridine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wei, Jiao Jiao published the artcileN,N-dimethyl-D-glucosamine as an efficient ligand for copper-catalyzed Ullmann-type coupling of N-H heterocycles with aryl halides, Recommanded Product: Ethyl 3-(4-iodophenyl)-3-oxopropanoate, the main research area is nitrogen heterocycle halobenzene glucosamine copper catalyst Ullmann coupling; arylated nitrogen heterocycle preparation green chem.

A new N,N-dimethyl-D-glucosamine ligand was developed for the copper-catalyzed Ullmann-type coupling of N-H heterocycles (e.g., indoles, benzimidazoles, pyrazoles and triazoles) with aryl halides. This method was accomplished not only featuring excellent yields, mild reaction conditions and simple operation, but also showing eco-friendly and broad-spectrum substrates and could be widely used in the construction of N-aryl heterocyclic systems.

Tetrahedron published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Recommanded Product: Ethyl 3-(4-iodophenyl)-3-oxopropanoate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com