Category: iodides-buliding-blocks

Lu, Xiao-Yu published the artcileTrisubstituted olefin synthesis via Ni-catalyzed hydroalkylation of internal alkynes with non-activated alkyl halides, Formula: C11H12INO2, the main research area is alkene preparation stereoselective regioselective; internal alkyne alkyl halide nickel catalyst hydroalkylation.

Ni-catalyzed regio- and stereo-selective hydroalkylation of internal alkynes R1CCR2 [R1 = Ph, pyridin-3-yl, (CH2)2CH3, etc.; R2 = Me, Ph, (CH2)3CH3, etc.] with non-activated alkyl halides XR3 (R3 = cyclohexyl, butan-2-yl, 1-[(4-methylbenzene)sulfonyl]pyrrolidin-3-yl, etc.; X = I, Br) was reported. This method does not use any sensitive organometallic reagents and shows good functional group compatibility, which enables the efficient synthesis of many tri-substituted olefins R1CH=C(R2)(R3) from readily available coupling partners. It also provides a straightforward method for the modification of bioactive organic mols.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, Formula: C11H12INO2.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Scheipers, Ina published the artcilePalladium-Catalyzed Decarboxylative γ-Arylation for the Synthesis of Tetrasubstituted Chiral Allenes, Synthetic Route of 2100-25-6, the main research area is alkynoic acid aryl iodide enantioselective palladium catalyst decarboxylative arylation; chiral tetrasubstituted allene stereoselective preparation; allenes; asymmetric synthesis; chirality transfer; cross-coupling; palladium.

An enantiospecific palladium-catalyzed decarboxylative coupling of acyclic β,γ-alkynoic acids with various aryl iodides to chiral tetrasubstituted allenes is described. The coupling reaction comprises a decarboxylative γ-palladation of α,α-disubstituted carboxylic acids to provide the tetrasubstituted allenes with complete point-to-axial chirality transfer in excellent yields.

Angewandte Chemie, International Edition published new progress about Allenes Role: SPN (Synthetic Preparation), PREP (Preparation). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Synthetic Route of 2100-25-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Obeid, Naim M. published the artcile(Oligo)aromatic species with one or two conjugated Si:Si bonds: near-IR emission of anthracenyl-bridged tetrasiladiene, Product Details of C10H13I, the main research area is disilene preparation crystal structure DFT calculation fluorescence; tetrasiladiene paraarylene bridged preparation crystal structure DFT calculation fluorescence; crystal structure disilene paraarylene bridged tetrasiladiene; mol structure disilene paraarylene bridged tetrasiladiene.

Aryl disilenes Tip2Si:Si(Tip)Ar (2a-d) and para-arylene bridged tetrasiladienes, Tip2Si:Si(Tip)-LU-Si(Tip):SiTip2 (3a-d) were synthesized by the transfer of the Tip2Si:SiTip unit to aryl halides and dihalides by nucleophilic disilenides Tip2Si:SiTipLi (Tip = 2,4,6-iPr3C6H2, Ar = aryl substituent, LU = para-arylene linking unit). The scope of the nucleophilic Si:Si transfer reaction is demonstrated to also include substrates of considerable steric bulk such as mesityl or duryl halides Ar-X (Ar = Mes = 2,4,6-Me3C6H2; Ar = Dur = 2,3,5,6-Me4C6H, X = Br or I). Bridged tetrasiladienes Tip2Si:Si(Tip)-LU-Si(Tip):SiTip2 with more extended linking units surprisingly exhibit fluorescence at room temperature, albeit weak. DFT calculations suggest that partial charge transfer character of the excited state is a possible explanation.

Dalton Transactions published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Product Details of C10H13I.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xiao, Li-Jun published the artcilePdII-Catalyzed Enantioselective C(sp3)-H Arylation of Cyclobutyl Ketones Using a Chiral Transient Directing Group, COA of Formula: C5H2F2IN, the main research area is arylcyclobutyl ketone regioselective diastereoselective enantioselective preparation; palladium catalyst stereoselective arylation cyclobutyl ketone transient directing group; C−H activation; arylation; palladium; pyridone ligands; transient directing groups.

In the presence of Pd(OAc)2, 3-nitro-5-trifluoromethyl-2-pyridone, and D-valine as a transient directing group reagent, cyclobutyl ketones such as I (R = H) underwent regioselective, diastereoselective, and enantioselective arylation with aryl iodides R1I (R1 = 4-MeO2CC6H4, 4-O2NC6H4, 4-MeCOC6H4, 4-NCC6H4, 4-F3CC6H4, 3-O2NC6H4, 3-PhCOC6H4, 3,4,5-F3C6H2, 3,5-Br2C6H3, 3-Br-5-ClC6H3, 4-Me-3-O2NC6H3, 2-Br-5-FC6H3, 6-F-3-pyridinyl, 2-F3C-4-pyridinyl, 6-Cl-5-F3C-3-pyridinyl, 6-Br-3-pyridinyl, 2,6-F2-4-pyridinyl, 2,6-F2-3-pyridinyl, 2,6-Cl2-4-pyridinyl, 5-acetyl-2-thienyl) to yield arylcyclobutyl ketones such as I (R = 4-MeO2CC6H4, 4-O2NC6H4, 4-MeCOC6H4, 4-NCC6H4, 4-F3CC6H4, 3-O2NC6H4, 3-PhCOC6H4, 3,4,5-F3C6H2, 3,5-Br2C6H3, 3-Br-5-ClC6H3, 4-Me-3-O2NC6H3, 2-Br-5-FC6H3, 6-F-3-pyridinyl, 2-F3C-4-pyridinyl, 6-Cl-5-F3C-3-pyridinyl, 6-Br-3-pyridinyl, 2,6-F2-4-pyridinyl, 2,6-F2-3-pyridinyl, 2,6-Cl2-4-pyridinyl, 5-acetyl-2-thienyl). In the presence of either L-valine as a transient directing group reagent or when silver trifluoroacetate, acetate, carbonate, or oxide were used as bases, enantiomeric arylcyclobutyl ketones were formed. A sequential diarylation was performed to yield diastereomeric diarylcyclobutyl ketones enantioselectively.

Angewandte Chemie, International Edition published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 685517-67-3 belongs to class iodides-buliding-blocks, name is 2,6-Difluoro-3-iodopyridine, and the molecular formula is C5H2F2IN, COA of Formula: C5H2F2IN.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Suzuki, Hitomi published the artcileThe reaction of polysubstituted aromatics. LVI. The copper(I) iodide-assisted reaction of nonactivated aryl iodides with some alkali metal pseudohalides, Formula: C10H13I, the main research area is aryl iodide substitution pseudohalide; azide substitution polymethylaryl iodide; selenocyanate substitution polymethylaryl iodide; tellurocyanate reaction polymethylaryl iodide; cyanide reaction polymethylaryl iodide; cyanide aryl.

CuI dissolves in warm (O)P(NMe2)3 to give a black solution in which polymethylated iodobenzenes undergo nucleophilic attack by azide and selenocyanate ions, giving the corresponding aryl azides and selenocyanates in low to good yields. In the absence of Cu(I) salt, however, the reaction does not take place. Cyanide, cyanate, thiocyanate, and fluoride ions cause a decoloration of the reaction mixture and no displacement reactions ensue, while the tellurocyanate ion gives the corresponding aryl cyanides while liberating elemental Te.

Bulletin of the Chemical Society of Japan published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Formula: C10H13I.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Zhenwei published the artcilePalladium-Catalyzed Hiyama Cross-Couplings of Arylsilanes with 3-Iodoazetidine: Synthesis of 3-Arylazetidines, Application In Synthesis of 939759-26-9, the main research area is arylazetidine preparation palladium catalyzed Hiyama cross coupling; cross coupling arylsilane iodoazetidine.

The first palladium-catalyzed Hiyama cross-coupling reactions of arylsilanes with 3-iodoazetidine were described. The protocol provides a convenient access to a variety of useful 3-arylazetidines which are of great interest in pharmaceutical laboratories in moderate to good yields (30%-88%). In addition, this strategy has the advantage of easy operation and mild reaction conditions.

Journal of Organic Chemistry published new progress about Aryl silanes Role: RCT (Reactant), RACT (Reactant or Reagent). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, Application In Synthesis of 939759-26-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Maya, Francisco published the artcileSynthesis of Fluorinated Oligomers toward Physical Vapor Deposition Molecular Electronics Candidates, Safety of 4-Iodo-3-nitroaniline, the main research area is fluorinated oligomer thiol nitrile pyridine chemisorption gold platinum; safety deprotection thioacetate.

New electron-deficient fluorinated oligo(phenylene ethynylenes) (OPEs) with varied functional groups were synthesized as free thiols, nitriles, and pyridines, ready to be used for surface adhesion. Calculated dipole moments suggest better matching between energy levels of bulk interfaces and mol. frontier orbitals when compared to nonfluorinated OPEs. Differential scanning calorimetry confirmed a higher thermal stability than the nonfluorinated counterparts. Surface anal. by ellipsometry, contact angle goniometry, cyclic voltammetry, and surface IR and XPS verified that the OPEs chemisorb on Au and Pt surfaces. On the basis of the phys. properties of the fluorinated OPEs, they might be useful in future phys. vapor deposition techniques, methods that are typically used in standard semiconductor fabrication processes. Safety: deprotection of a thioacetate derivative led to a violent explosion.

Chemistry of Materials published new progress about Differential scanning calorimetry (of fluorinated oligo(phenylene ethynylenes)). 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Safety of 4-Iodo-3-nitroaniline.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Lei published the artcileModification of the aminopyridine unit of 2′-deoxyaminopyridinyl-pseudocytidine allowing triplex formation at CG interruptions in homopurine sequences, Quality Control of 25391-56-4, the main research area is aminopyridine derive sequence synthesis CG inversion site.

The antigene strategy based on site-specific recognition of duplex DNA by triplex DNA formation has been exploited in a wide range of biol. activities. However, specific triplex formation is mostly restricted to homo-purine strands within the target duplex DNA, due to the destabilizing effect of CG and TA inversion sites where there is an absence of natural nucleotides that can recognize the CG and TA base pairs. Hence, the design of artificial nucleosides, which can selectively recognize these inversion sites with high affinity, should be of great significance. Recently, we determined that 2-amino-3-methylpyridinyl pseudo-dC (3MeAP-VdC) possessed significant affinity and selectivity toward a CG inversion site and showed effective inhibition of gene expression. We now describe the design and synthesis of new modified aminopyridine derivatives by focusing on small chem. modification of the aminopyridine unit to tune and enhance the selectivity and affinity toward CG inversion sites. Remarkably, we have newly found that 2-amino-4-methoxypyridinyl pseudo-dC (4OMeAP-VdC) could selectively recognize the CG base pair in all four adjacent base pairs and form a stable triplex structure against the promoter sequence of the human gene including multiple CG inversion sites.

Nucleic Acids Research published new progress about Aminopyridines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 25391-56-4 belongs to class iodides-buliding-blocks, name is 3-Iodo-5-nitropyridin-2-amine, and the molecular formula is C5H4IN3O2, Quality Control of 25391-56-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Dacheng published the artcileEnantio-Relay Catalysis Constructs Chiral Biaryl Alcohols over Cascade Suzuki Cross-Coupling-Asymmetric Transfer Hydrogenation, Application of Ethyl 3-(4-iodophenyl)-3-oxopropanoate, the main research area is chiral biaryl alc green preparation cascade enantio relay catalysis; haloacetophenone arylboronic acid Suzuki cross coupling asym transfer hydrogenation.

The use of an imidazolium-based organopalladium-functionalized organic-inorganic hybrid silica and ethylene-coated chiral organoruthenium-functionalized magnetic nanoparticles to catalyze a cascade Suzuki cross-coupling-asym. transfer hydrogenation reaction to prepare chiral biaryl alcs. in a two-step, one-pot process is reported. As expected, the site-isolated active species, salient imidazolium phase-transfer character and high ethylene-coated hydrophobicity can synergistically boost the catalytic performance. Furthermore, enantio-relay catalysis has the potential to efficiently prepare a variety of chiral biaryl alcs. This synthetic strategy is a general method that shows the potential of developing enantio-relay catalysis towards environmentally benign and sustainable organic synthesis.

Scientific Reports published new progress about Alcohols, chiral Role: SPN (Synthetic Preparation), PREP (Preparation) (biaryl). 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Application of Ethyl 3-(4-iodophenyl)-3-oxopropanoate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Juarez-Ornelas, Kevin A. published the artcileIodine(III)-Catalyzed Electrophilic Nitration of Phenols via Non-Bronsted Acidic NO2+ Generation, Recommanded Product: 4-Iodo-2-nitrophenol, the main research area is nitrophenol preparation iodine catalyzed electrophilic nitration phenol.

The first catalytic procedure for the electrophilic nitration of phenols was developed using iodosylbenzene as an organocatalyst based on iodine(III) and aluminum nitrate as a nitro group source. This atom-economic protocol occurs under mild, non-Bronsted acidic and open-flask reaction conditions with a broad functional-group tolerance including several heterocycles. D. functional theory (DFT) calculations at the (SMD:MeCN)Mo8-HX/(LANLo8+f,6-311+G*) level indicated that the reaction proceeds through a cationic pathway that efficiently generates the NO2+ ion, which is the nitrating species under neutral conditions.

Organic Letters published new progress about Aromatic nitro compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Recommanded Product: 4-Iodo-2-nitrophenol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com