Category: iodides-buliding-blocks

Lu, Xi published the artcileNickel-Catalyzed Defluorinative Reductive Cross-Coupling of gem-Difluoroalkenes with Unactivated Secondary and Tertiary Alkyl Halides, Name: Benzyl 3-iodoazetidine-1-carboxylate, the main research area is arylfluoroalkene chemoselective diastereoselective preparation; nickel imidazolinylpyridine catalyst defluorinative reductive coupling aryldifluoroalkene bromoalkane iodoalkane; secondary tertiary bromoalkane chloroalkane reductive coupling aryldifluoroalkene nickel catalyst.

In the presence of Ni(cod)2 and an imidazolinylpyridine ligand, 1,1-difluoroalkenes such as I underwent chemoselective and diastereoselective reductive defluorinative coupling reactions with secondary alkyl bromides and iodides such as iodocyclohexane mediated by bis(pinacolato)diboron and tripotassium phosphate to yield (Z)-arylfluoroalkenes such as II in 36-95% yields and in 8:1->50:1 Z:E diastereoselectivities; the reaction was also used to couple difluoroalkenes with primary alkyl iodides and 1,1-difluoroalkyl bromides using a catalyst generated from NiBr2(diglyme) and 4,7-dimethoxy-1,10-phenanthroline.

Journal of the American Chemical Society published new progress about Bromoalkanes Role: RCT (Reactant), RACT (Reactant or Reagent). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, Name: Benzyl 3-iodoazetidine-1-carboxylate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reitti, Marcus published the artcileSynthesis of Phenols and Aryl Silyl Ethers via Arylation of Complementary Hydroxide Surrogates, Related Products of iodides-buliding-blocks, the main research area is diaryliodonium salt silanol arylation; hydrogen peroxide diaryliodonium salt arylation; aryl silyl ether preparation; phenol preparation.

Two transition-metal-free methods to access substituted phenols via the arylation of silanols or hydrogen peroxide with diaryliodonium salts are presented. The complementary reactivity of the two nucleophiles allows synthesis of a broad range of phenols without competing aryne formation, as illustrated by the synthesis of the anesthetic Propofol. Furthermore, silyl-protected phenols can easily be obtained, which are suitable for further transformations.

Organic Letters published new progress about Alkynes, arynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Related Products of iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xia, Guoqin published the artcileLigand-Enabled β-Methylene C(sp3)-H Arylation of Masked Aliphatic Alcohols, SDS of cas: 685517-67-3, the main research area is methylene arylation aliphatic alc salicylic directing group pyridone ligand; C−H activation; aliphatic alcohols; directing groups; ligands; synthetic methods.

Despite recent advances, reactivity and site-selectivity remain significant obstacles for the practical application of C(sp3)-H bond functionalization methods. Here, we describe a system that combines a salicylic-aldehyde-derived L,X-type directing group with an electron-deficient 2-pyridone ligand to enable the β-methylene C(sp3)-H arylation of aliphatic alcs., which has not been possible previously. Notably, this protocol is compatible with heterocycles embedded in both alc. substrates and aryl coupling partners. A site- and stereo-specific annulation of dihydrocholesterol and the synthesis of a key intermediate of englitazone illustrate the practicality of this method.

Angewandte Chemie, International Edition published new progress about Arylation. 685517-67-3 belongs to class iodides-buliding-blocks, name is 2,6-Difluoro-3-iodopyridine, and the molecular formula is C5H2F2IN, SDS of cas: 685517-67-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Albadi, Jalal published the artcileRegioselective iodination of aromatic compounds with potassium iodide in the presence of benzyltriphenylphosphonium perchlorate, Application In Synthesis of 21784-73-6, the main research area is regioselective iodination aromatic compound potassium iodide benzyltriphenylphosphonium perchlorate.

A simple and efficient method for the selective iodination of various aromatic compounds by using potassium iodide in the presence of benzyltriphenylphosphonium perchlorate, is reported. This method provides several advantages such as good selectivity between ortho and para positions of aromatic compounds and high yields of the products.

Chinese Chemical Letters published new progress about Iodination, regioselective. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Application In Synthesis of 21784-73-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Schlosser, Manfred published the artcileThe reactivity of 2-fluoro- and 2-chloropyridines toward sodium ethoxide: Factors governing the rates of nucleophilic (het)aromatic substitutions, Synthetic Route of 685517-67-3, the main research area is reactivity fluoropyridine chloropyridine sodium ethoxide nucleophilic aromatic heteroaromatic substitution.

The relative displacement rates of the halide substituent from 2-fluoro- and 2-chloropyridines by EtONa in EtOH at +25° were assessed by competition kinetics. The 2-fluoropyridine reacts 320 times faster than the chloro analog. A CF3 group increases the reactivity more than single halogen atoms do, whatever the element, and the latter are superior to Me3Si groups. Substituents accommodated at the 4-position operate through their inductive effect, whereas at the 3-position, this action may be attenuated by steric hindrance. Almost all 5-substituents enhance the rate of the nucleophilic substitution occurring at the 2-position. The sole exception concerns the F-atom at the 5-position which retards the reaction, presumably by lone-pair/lone-pair repulsion with the neg. charge building up at the central C-atom of the intermediate Meisenheimer complex. The substituent effects are additive. Therefore, by using the increments derived from the present work, the rates of future reactions should be predictable with fair accuracy.

Helvetica Chimica Acta published new progress about Ethoxylation kinetics. 685517-67-3 belongs to class iodides-buliding-blocks, name is 2,6-Difluoro-3-iodopyridine, and the molecular formula is C5H2F2IN, Synthetic Route of 685517-67-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pierre, Romain published the artcileNovel library synthesis of 3,4-disubstituted pyridin-2(1H)-ones via cleavage of pyridine-2-oxy-7-azabenzotriazole ethers under ionic hydrogenation conditions at room temperature, SDS of cas: 884494-51-3, the main research area is disubstituted pyridinone preparation kinase inhibitor; 7-azabenzotriazole; hinge-binder; ionic hydrogenation; library; pyridine-2(1H)-one.

A novel complementary multiparallel synthetic routes permitting the exploitation of the C-3 then C-4 vectors or vice versa to deliver library of novel 3,4-disubstituted pyridin-2(1H)-one kinase inhibitors I [R = (CH2)3OCH3, Ph, 2-EtC6H4, etc.; R1 = 4-NH2C6H10, CH2C(Me)2CH2NH2, cyclohexyl, etc.; R2 = H; R1R2 = CH2CH2OCH2CH2] starting from readily-available 2-chloro-4-fluoronicotinic acid and 2-fluoro-4-iodonicotinic acid resp. was developed. Perhaps the highlight of library route development was the novel transformation to the desired pyridin-2(1H)-one motif via in situ formation of the C2-OAt ether during HATU coupling and its cleavage under ionic hydrogenation conditions at just room temperature

Beilstein Journal of Organic Chemistry published new progress about Enzyme inhibitors (kinase). 884494-51-3 belongs to class iodides-buliding-blocks, name is 2-Fluoro-4-iodonicotinic acid, and the molecular formula is C6H3FINO2, SDS of cas: 884494-51-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sigala, Ioanna published the artcileLynamicin D an antimicrobial natural product affects splicing by inducing the expression of SR protein kinase 1, Safety of tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate, the main research area is lynamicin D bisindolyl bisindole pyrrole alkaloid mRNA splicing SRPK1; Bisindole pyrroles; Bisindolyl alkaloids; Lynamicin D; SRPK1; mRNA splicing.

The first total synthesis of the antimicrobial natural product lynamicin D has been developed using a Suzuki coupling to construct the bisindole pyrrole skeleton. An evaluation of the biol. activity of lynamicin D reveals that it has a minor effect on cell viability but it can modulate splicing of pre-mRNAs. We provide evidence that this effect is mainly due to the ability of lynamicin D to alter the levels of SRPK1, the key kinase involved in both constitutive and alternative splicing.

Bioorganic & Medicinal Chemistry published new progress about Homo sapiens. 1048039-49-1 belongs to class iodides-buliding-blocks, name is tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate, and the molecular formula is C13H13ClINO2, Safety of tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Knipe, Peter C. published the artcileA Lewis acid-mediated conformational switch, Quality Control of 105752-04-3, the main research area is pyridine alkyne ethyne benzoate preparation mol switch.

Mols. that change conformation in response to a stimulus have numerous uses, such as artificial chemoreceptors, novel drug delivery strategies and liquid crystal technol. Here the authors describe the design, synthesis and conformational behavior of an isonicotinamide-substituted diphenylacetylene upon recognition of Lewis acids, including metalloporphyrins. Binding of these at a remote site (i.e., pyridine nitrogen) increases hydrogen-bond donor ability of the proximal amide NH, causing an increased preference for the alkyne rotamer in which this hydrogen bond is maintained. The synthesis of the target compound was achieved by a reaction of 2-[2-[2-amino-6-(benzoylamino)phenyl]ethynyl]benzoic acid Me ester with 4-pyridinecarbonyl chloride. The title compound thus formed was a bis[amide] compound [[[[(pyridinyl)carbonyl]amino][(benzoyl)amino]phenyl]ethynyl]benzoic acid ester. The alkyne link permits a rapid interchange between conformers and the preferred conformation is determined by the hydrogen-donor properties of the amide bonds. Conformational changes were induced by various Lewis acids, such as [5,10,15,20-tetrakis[3,5-bis(1,1-dimethylethyl)phenyl]-21H,23H-porphinato(2-)-κN21,κN22,κN23,κN24]zinc (metalloporphyrin), trifluoroacetic acid, trifluoro[1,1′-oxybis[ethane]]boron (boron trifluoride etherate).

Organic & Biomolecular Chemistry published new progress about Chemoreceptors Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), PROC (Process), PREP (Preparation). 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Quality Control of 105752-04-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Weis, Jonathan G. published the artcileEmploying Halogen Bonding Interactions in Chemiresistive Gas Sensors, Category: iodides-buliding-blocks, the main research area is halogen bonding interaction chemiresistive gas sensor pyridine picoline detection.

This paper reports the use of halogen bonding interactions for gas-phase detection of pyridine in SWCNT-based chemiresistive sensors with sub-ppm theor. detection limits. The chemiresistors were prepared by solvent-free ball-milling of single-walled carbon nanotubes (SWCNTs) and aryl halide-based selectors, compression into a pellet, and subsequent mech. abrasion between gold electrodes on paper. The sensing responses reflect halogen bonding trends, with few exceptions. The predominant signal transduction mechanism is likely attributed to swelling of the insulating haloarene matrix.

ACS Sensors published new progress about Carbon nanotubes. 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Category: iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yi, Jun published the artcileNickel-catalyzed Sonogashira reactions of non-activated secondary alkyl bromides and iodides, HPLC of Formula: 939759-26-9, the main research area is internal alkyne preparation; terminal alkyne alkyl halide Sonogashira coupling nickel catalyst; alkynes; cross-coupling; halides; nickel; synthetic methods.

A nickel-catalyzed Sonogashira cross-coupling of terminal alkynes with non-activated secondary alkyl iodides and bromides is described. This reaction provides a useful approach to the synthesis of substituted alkynes (in particular, dialkylated asym. alkynes) from readily available substrates. The bis(oxazoline) family of ligands was found to be effective for mediating nickel-catalyzed C(sp)-C(sp3) cross-couplings of both secondary and primary alkyl halides under fairly mild reaction conditions (room temperature to -20°C). This reaction exhibited good compatibility with a variety of synthetically important functional groups and therefore, could be used for the synthesis and modifications of biol. relevant mols. Furthermore, high diastereoselectivities were observed in C(sp)-C(sp3) cross-couplings of terminal alkynes with 1,3- and 1,4-substituted cyclohexyl iodides.

Angewandte Chemie, International Edition published new progress about Alkynes, α- Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, HPLC of Formula: 939759-26-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com