iodides-buliding-blocks Archives - Page 184 of 923

Wang, Heng-Yen’s team published research in Journal of Organic Chemistry in 2011-05-06 | CAS: 63131-30-6

Journal of Organic Chemistry published new progress about Isomerization. 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Application In Synthesis of 63131-30-6.

Wang, Heng-Yen published the artcileRegioselective synthesis of 2,3,4- or 2,3,5-trisubstituted pyrroles via [3,3] or [1,3] rearrangements of O-vinyl oximes, Application In Synthesis of 63131-30-6, the main research area is pyrrole derivative regioselective synthesis; vinyl oxime isomerization sigmatropic rearrangement Ir catalyst.

The regioselective synthesis of 2,3,4- or 2,3,5-trisubstituted pyrroles e. g., I has been achieved via [3,3] and [1,3] sigmatropic rearrangements of O-vinyl oximes, resp. Iridium-catalyzed isomerization of easily prepared O-allyl oximes enables rapid access to O-vinyl oximes. Optimization and scope of the O-allyl oxime isomerization and subsequent pyrrole formation are discussed and mechanistic pathways are proposed. The regioselectivity of pyrrole formation can be controlled by either the identity of the α-substituent or through the addition of an amine base. When enolization is favored, a [3,3] rearrangement followed by a Paal-Knorr cyclization provides a 2,3,4-trisubstituted pyrrole; when enolization is disfavored, a [1,3] rearrangement occurs prior to enolization to produce a 2,3,5-trisubstituted pyrrole after cyclization. Conditions are provided for selecting either the [3,3] rearrangement or the [1,3] rearrangement product with β-ester O-allyl oxime substrates.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shimizu, Kazuki’s team published research in Bioorganic & Medicinal Chemistry Letters in 2010-02-15 | CAS: 21784-73-6

Bioorganic & Medicinal Chemistry Letters published new progress about Boronic acids, esters Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation). 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Application of 4-Iodo-2-nitrophenol.

Shimizu, Kazuki published the artcileBoron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1α inhibitors, Application of 4-Iodo-2-nitrophenol, the main research area is boron containing phenoxyacetanilide derivative preparation hypoxia inducible factor inhibition; carboranylphenoxyacetanilide boronic acid derivative preparation HIF VEGF inhibition; aryloxyacetanilide pinacolboronate hypoxia induced HIF transcriptional activity inhibitor HeLa.

A series of boron-containing phenoxyacetanilide derivatives I [R1 = BPin, B(OH)2; R2 = Me, Et, Ph, Cy, 1-adamantyl, t-Bu, o-carboranyl] were synthesized as hypoxia-inducible factor (HIF)-1α inhibitors. Among the compounds synthesized, carboranylphenoxyacetanilide I [R1 = B(OH)2; R2 = o-carboranyl (II)] was found to be a potent inhibitor against HIF-1α accumulation under hypoxic conditions and inhibited the hypoxia-induced HIF-1 transcriptional activity in HeLa cells (IC50 = 0.74 μM). Compound II (GN26361) suppressed hypoxia-induced HIF-1α accumulation and vascular endothelial growth factor mRNA expression in a concentration-dependent manner without affecting the expression of HIF-1α mRNA.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tejo, Ciputra’s team published research in Synlett in 2014 | CAS: 63131-30-6

Synlett published new progress about Amination. 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Related Products of iodides-buliding-blocks.

Tejo, Ciputra published the artcileBronsted acid catalyzed amination of 1,3-dicarbonyl compounds by iminoiodanes, Related Products of iodides-buliding-blocks, the main research area is Bronsted acid catalyst amination dicarbonyl compound iminoiodane.

A synthetic method to aminate 1,3-dicarbonyl compounds with PhI:NTs using Bronsted acid catalysis is described herein. The method was shown to be applicable to β-keto esters and phosphonates as well as 1,3-diones, providing the corresponding α,α-acyl amino acid derivatives in moderate to excellent yields. E.g., amination of PhCOCH2CO2Et with PhI:NTs in the presence of 10 mol% of TFA and 4 Å MS in dichloromethane at 0 °C for 90 min gave 85% aminated product I.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Watson, Rebecca B.’s team published research in Organic Letters in 2016-03-18 | CAS: 63131-30-6

Organic Letters published new progress about Cyclization. 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Safety of Ethyl 3-(4-iodophenyl)-3-oxopropanoate.

Watson, Rebecca B. published the artcileIron(III) Chloride Catalyzed Formation of 3,4-Dihydro-2H-pyrans from α-Alkylated 1,3-Dicarbonyls. Selective Synthesis of α- and β-Lapachone, Safety of Ethyl 3-(4-iodophenyl)-3-oxopropanoate, the main research area is dihydropyran preparation iron chloride catalyzed cyclization; lapachone synthesis iron chloride catalyzed cyclization.

A mild, catalytic method for the synthesis of 3,4-dihydro-2H-pyrans is described. The FeCl3-catalyzed transformation of aryl- and alkyl β-diketones enables synthetic access to functionalized pyran core structures incorporated in many natural products and biol. active target structures. The method represents a mild alternative to currently available reaction protocols relying on stoichiometric reagents and harsh reaction conditions. This FeCl3-catalyzed transformation has enabled the selective synthesis of α-lapachone in two synthetic transformations and subsequently β-lapachone in three synthetic transformations, which is currently undergoing clin. trials as a potent anticancer agent.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Yibiao’s team published research in Journal of Organic Chemistry in 2018-08-03 | CAS: 153034-78-7

Journal of Organic Chemistry published new progress about Cyclization. 153034-78-7 belongs to class iodides-buliding-blocks, name is 2-Fluoro-3-iodo-5-methylpyridine, and the molecular formula is C6H5FIN, SDS of cas: 153034-78-7.

Li, Yibiao published the artcile2-Acetylthienopyridine Synthesis via Thiolation and Copper-Catalyzed Cyclization of o-Propynol Fluoropyridine Using Xanthate as a Thiol Surrogate, SDS of cas: 153034-78-7, the main research area is fluoropyridinylalkynol xanthate thiolation cyclization oxidation copper; thienopyridine preparation; copper thiolation cyclization oxidation catalyst.

2-Acylthienopyridines and related heterocycles are readily prepared in moderate to good yields under mild conditions by a nucleophilic thiolation, copper-catalyzed cyclization, and an oxidation cascade process using potassium xanthate as the thiol source. Moreover, excellent chemoselectivity, broad substrate scope, and good functional group tolerance are prominent features of this transformation.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reichert, Veronica R. et al. published their research in Macromolecules in 1994 |CAS: 144970-30-9

The Article related to adamantane catalyst polycondensation iodoaniline, polyamide star preparation adamantane core, aramid star preparation tetrakisiodophenyladamantane, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Formula: C34H28I4

On November 21, 1994, Reichert, Veronica R.; Mathias, Lon J. published an article.Formula: C34H28I4 The title of the article was Tetrahedrally-Oriented Four-Armed Star and Branched Aramids. And the article contained the following:

Palladium-catalyzed carbonylation of 4-iodoaniline in the presence of 1,3,5,7-tetrakis(4-iodophenyl)adamantane or 1,3,5,7-tetrakis(4-aminophenyl)adamantane cores gave the corresponding four-armed star polybenzamides. Tetraphenyladamantane incorporation was confirmed by 13C solution and solid-state CP/MAS NMR and FTIR. The stars exhibited the same thermal stability as linear polybenzamide synthesized by the same route. The star with the amine core exhibited the highest intrinsic viscosity in sulfuric acid ([畏] = 0.74 dL/g), and films could be cast from dilute DMAC-5% LiCl solutions Tetraphenyladamantane incorporation (confirmed by solid-state CP/MAS 13C NMR and FTIR) significantly increased solubility Branched aramids synthesized from 3,5-dibromoaniline under Pd-catalyzed carbonylation conditions were compared to a branched system based on 1,3,5,7-tetrakis(4-iodophenyl)adamantane. The former were insoluble, while the adamantane materials were slightly soluble in DMAC and H2SO4; both hyperbranched polymers tenaciously held residual solvent and could not be completely dried. These results confirm both the incorporation of the tetrasubstituted adamantyl core into both star and hyperbranched polymers and the possibility of property modification through disruption of chain packing and enforced tetrahedral arm orientation at the core. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Formula: C34H28I4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reichert, Veronica R. et al. published their research in Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) in 1993 |CAS: 144970-30-9

The Article related to tetrakisiodophenyl adamantane preparation, tetrahedral adamantane derivative nmr spectrum, ir spectrum tetrahedral adamantane derivative, Chemistry of Synthetic High Polymers: Monomers and Reagents Used In Polymerization and other aspects.Related Products of 144970-30-9

On March 31, 1993, Reichert, Veronica R.; Mathias, Lon J. published an article.Related Products of 144970-30-9 The title of the article was Rigid-expanded tetrahedral cores for four-armed branched structures: 1,3,5,7-tetrakis(4-iodophenyl)adamantane and its derivatives. And the article contained the following:

1,3,5,7-Tetrakis(4-iodophenyl)adamantane (I) was an ideal starting material for the preparation of rigid, expanded tetrahedral core mols. Pd-catalyzed coupling of I with 1-decene gave acceptable yields of 1,3,5,7-tetrakis(1-decenyl)adamantane, a model for all-hydrocarbon star-polymer systems. 1,3,5,7-Tetrakis(4-carboxyphenyl)adamantane (II) was obtained from a Grignard-type reaction of I with sec-BuLi followed by reaction with CO2 and acidification. Direct condensation of II with 1-aminoadamantane in the presence of triphenylphosphine and hexachloroethane gave the tetra-adamantyl amide. These monomers could be used for the preparation of macromols. with enforced 3-dimensional structures. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Related Products of 144970-30-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lim, Ho et al. published their research in Macromolecules (Washington, DC, United States) in 2010 |CAS: 144970-30-9

The Article related to preparation click chem adamantane adsorbent microemulsion polymerization polyacetylene, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Recommanded Product: 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

On September 14, 2010, Lim, Ho; Chang, Ji Young published an article.Recommanded Product: 1,3,5,7-Tetrakis(4-iodophenyl)adamantane The title of the article was Preparation of Clickable Microporous Hydrocarbon Particles Based on Adamantane. And the article contained the following:

The author’s prepared clickable microporous hydrocarbon particles based on an adamantane building block. The particle morphologies were controlled by varying the polymerization conditions. Spherical particles with a high surface area were obtained by the polymerization in a miniemulsion state. The polymer particles were easily modified via the click reaction, which provides a potential tool to tailor the chem. and phys. properties of porous particles to meet the requirements of specific applications. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Recommanded Product: 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rong, Meng et al. published their research in Microporous and Mesoporous Materials in 2021 |CAS: 144970-30-9

The Article related to tetraphenyladamantane microporous polyamine adsorption voc, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Quality Control of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

On August 31, 2021, Rong, Meng; Yang, Liangrong; Yang, Chao; Yu, Jiemiao; Liu, Huizhou published an article.Quality Control of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane The title of the article was Tetraphenyladamantane-based microporous polyaminals for efficient adsorption of CO2, H2 and organic vapors. And the article contained the following:

Herein, a new tetraphenyladamantane-cored triazine-based multiamine (TPADT) was designed and synthesized. Its bulky mol. volume, strong rigidity, and high amine functionality enable it easy to prop up the polymer backbone and form a high hypercrosslinking degree to obtain high microporosity. A series of highly microporous tetraphenyladamantane-based polyaminals (Ad-MALPs) were prepared through the catalyst-free copolymerization of TPADT and com. aromatic aldehydes. By changing the strut length and functionality of aldehyde monomers, the resulting polymers exhibit tailored BET surface area (1541-1779 m2/g) and narrow ultra-micropore size distribution (0.52-0.93 nm). Ad-MALP-2 with the largest microporosity possesses the highest CO2 uptake (21.1 wt %, 273 K/1.0 bar) and CO2/N2 adsorption selectivity (35.2). Interestingly, Ad-MALP-3 shows the highest H2 uptake (2.26 wt%, 77 K/1.0 bar) due to larger total pore volume In addition, highly microporous Ad-MALPs simultaneously contain aromatic and cycloaliphatic components, and thus show exceptionally large aromatic and cycloaliphatic organic vapor adsorption capacity under low pressure. At P/P0 = 0.1, the benzene and cyclohexane vapor uptakes of Ad-MALPs are up to 44.8 wt% and 39.0 wt %, far exceeding that of most previously reported porous organic polymers. Considering that Ad-MALPs have outstanding gas adsorption performance, simple preparation, good stability, and cycle ability, they are expected to be promising adsorbent materials for CO2 adsorption/separation, H2 storage and low-concentration volatile organic vapors capture. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Quality Control of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mathias, Lon J. et al. published their research in Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) in 1992 |CAS: 144970-30-9

The Article related to adamantane macromonomer dendritic polymer, Chemistry of Synthetic High Polymers: Monomers and Reagents Used In Polymerization and other aspects.Category: iodides-buliding-blocks

On August 31, 1992, Mathias, Lon J.; Reichert, Veronica R.; Muir, Andrew V. G. published an article.Category: iodides-buliding-blocks The title of the article was Synthesis of macromolecules from 1,3,5,7-tetra(4-iodophenyl)adamantane: a new core for dendritic molecules. And the article contained the following:

The title compound was prepared by iodination of 1,3,5,7-tetraphenyladamantane and subsequently derivatized with 2-methyl-3-butyn-2-ol to give the tetrakis(3-hydroxy-3,3-dimethyl-1-propyn-1-yl) derivative (I) or with phenylboronic acid to give tetrabiphenylyladamantane. I was deprotected to give the ethynyl derivative The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com