Category: iodides-buliding-blocks

Electric Literature of 10297-05-9,Some common heterocyclic compound, 10297-05-9, name is 1-Chloro-4-iodobutane, molecular formula is C4H8ClI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Chloro-1-(3-pyridyloxy)butane Under a nitrogen atmosphere, a solution of 3-hydroxypyridine (3.50 g, 36.8 mmol) in N,N-dimethylformamide (DMF) (10 mL) was added drop-wise over 5 min to a cold (0-5° C.), stirring slurry of sodium hydride (1.16 g of an 80percent dispersion in mineral oil, 38.6 mmol) in DMF (40 mL). The mixture was allowed to stir and warm to ambient temperature over 1 h. The mixture was then cooled to 0-5° C., and 1-chloro-4-iodobutane (9.67 g, 44.2 mmol) was added drop-wise over 5 min. The resulting dark-brown mixture was stirred at ambient temperature for 2 h. Water (25 mL) was added, followed by saturated NaCl solution (25 mL), and the mixture was extracted with ether (4*50 mL). The combined ether extracts were dried (Na2SO4), filtered, and concentrated by rotary evaporation to a residue that was dried briefly under high vacuum to give 6.89 g (quantitative yield) of an oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Chloro-4-iodobutane, its application will become more common.

Electric Literature of 16932-44-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16932-44-8, name is 2-Iodo-1,3-dimethoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 2,6-dimethoxyiodobenzene (40.1 mg, 151 mumol), Bu3SnH (48.7 muL, 181 mumol), and V-65 (7.5 mg, 30.2 mumol) in THF-d8 (4 mL) was stirred at reflux for 3 h. Bu3SnH (48.7 muL, 181 mumol) and V-65 (7.5 mg, 30.2 mumol) were added, and the mixture was stirred at reflux for 2 h. The mixture was concentrated in vacuo, and the residue was purified by column chromatography on silica gel (pentane/Et2O=40:1) to give 2-deutero-1,3-dimethoxybenzene (21.1 mg, 100%). 1H NMR (400 MHz): 3.72 (s, 6H, O-CH3), 6.46-6.51 (m, 2.15H, 2-H, 4-H, 6-H), 7.17 (t, J=8.1 Hz, 1H, 5-H); 2H NMR: 6.50 (br); MS(EI+): m/z 139 [M]+; HRMS (EI+): calcd for C8H92HO2 [M]+: 139.07436, found: 139.07515.

The chemical industry reduces the impact on the environment during synthesis 2-Iodo-1,3-dimethoxybenzene. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4387-36-4, name is 2-Iodobenzonitrile, A new synthetic method of this compound is introduced below., name: 2-Iodobenzonitrile

S1:100 mmol of the compound of the above formula (1), 150 mmol of the compound of the above formula (2), 0.8 mmol of palladium acetate, 100 mmol of tetra-n-butylammonium bromide were added to an appropriate amount of the organic solvent N,N-dimethylacetamide (DMA) at room temperature. And 225 mmol of sodium carbonate, and then the temperature was raised to 95 ° C with stirring, and the reaction was stirred at this temperature for 25 hours;After the reaction was completed, the reaction mixture was poured into a sufficient amount of ethyl acetate, and then washed with saturated brine, and the organic layer and aqueous layer were separated, and the aqueous layer was extracted with ethyl acetate. The organic layer and the organic layer obtained by ethyl acetate extraction were dried over anhydrous Na 2 SO 4 and evaporated under reduced pressure. The elution is carried out, the eluent is collected and the eluent is removed by evaporation.The compound of the above formula (3) is thus a white solid, the yield is 87.6percent;

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32024-15-0, name is 3-Iodo-4,5-dimethoxybenzaldehyde, A new synthetic method of this compound is introduced below., COA of Formula: C9H9IO3

(3-Iodo-4,5-dimethoxyphenyl)methanoI (3). A method of Chowdhury and co-workers was modified. A 250 mL, three-necked, round-bottomed flask, equipped with a magnetic stir bar and a condenser was charged with 2 (25 g, 85 mmol) and 100 mL of THF. Sodium borohydride (1.91 g, 50 mmol) was added slowly portion- wise over a period of 5 min and the reaction mixture was stirred at room temperature for 45 min. The reaction mixture was quenched with 100 mL of saturated NH4C1 and extracted with ethyl acetate (3 x 125 mL). The combined organic layers were washed with saturated NaCl (100 mL), dried (MgS04) and concentrated under vacuum to yield 3 (24.8 g, 98.8%) as a thick colorless liquid. IR: 3392, 2824 cm”1; H-NMR(CDC13): delta 7.27 (d, J= 1.6 Hz, 1H), 6.86 (d, J = 1.6 Hz, 1H), 4.53 (s, 2H), 3.83 (s, 3H), 3.79 (s, 3H), 2.83 (br s, 1H); I3C-NMR (CDC13): 5 152.4, 147.7, 139.0, 128.3, 111.2, 92.1, 63.9, 60.3, 55.8.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6326-42-7, name is Methyl 2-iodo-4-nitrobenzoate, A new synthetic method of this compound is introduced below., SDS of cas: 6326-42-7

A solution of the compound 8 (10.0 g, 32.57 mmol) and SnCl2. 2 hi) (22.04 g, 97,69 mmol, 3 equiv.) in EtOAc ( 150 mL) was refluxed for 5 hours until TLC (EtOAc/hexane, 1 : 1) indicated that reaction was complete. The reaction mixture was poured in a 500 ml beaker and it was diluted with 100 ml of EtOAc followed by the addition of potassium carbonate and 200 ml of deionized water and the two layer mixture was stirred for 30 minutes. The milky suspension was filtered through a short bed of CELITE and the organic layer was separated. The combined organic layer was sequentially treated with saturated brine and anhydrous Na2S0 . Purification by flash column chromatography using EtOAc: petroleum ether (1 : 1) afforded a pale yellow solid 9 (5.86 g, 65% yield). [0396] FontWeight=”Bold” FontSize=”10″ 1I NMR (400 MHz, CDC13, TMS) delta 3.86 (s, 3H), 4.01 (broad singlet, 2H), 6.58-6.64 (dd, IH, Jj = 2.29 Hz, J2 = 8.70 Hz), 7.30 (d, 1H, J = 2.29 Hz), 7.77 (d, 1H, J – 8.24 Hz). 1 C NMR (100 MHz, CDC13) delta: 51.87, 96.53, 1 13,44, 127,03, 132.95, 150,24, 165,92, MS (ESI): m/z (%) 300. 9 (M Xa }

The synthetic route of 6326-42-7 has been constantly updated, and we look forward to future research findings.

Reference of 39959-51-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39959-51-8 name is (2-Iodophenyl)methanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 2-/3-/4-Iodobenzyl chloride (1a-c) was dissolved in chloroform containing 1.1 equivalents of triethylamine. A solution of substituted benzoyl chloride (2a-g) in chloroform was added dropwise with stirring over 15min. The precipitate that formed was removed by filtration and the resulting filtrate was washed sequentially with water, 1N hydrochloric acid, 5% sodium carbonate and brine. The organic phase was dried over magnesium sulfate (anhyd.), filtered, evaporated to dryness and the resultant 2-/3/-4-substituted-N-(2/3/4-iodo)- benzylbenzamide 3a-i was recrystallized from alcohol. To obtain the corresponding 2-/4-iodo-N-substituted benzyl benzamide derivatives, the same procedure was followed, except that the 2-/4-iodobenzoyl chlorides 2h,2i and isomeric 2-/4-methoxybenzylamines 1d,1e were used. All new compounds 3a-i and 4a-d were characterized by 1H, 13C NMR spectrometry, and elemental analysis or LC-MS.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (2-Iodophenyl)methanamine, and friends who are interested can also refer to it.

Synthetic Route of 175278-11-2, A common heterocyclic compound, 175278-11-2, name is 1-Bromo-3,5-difluoro-2-iodobenzene, molecular formula is C6H2BrF2I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a cooled solution of l-bromo-3,5-difluoro-2-iodobenzene (10.0 g, 31.4 mmol) in THF (25 mL, 1.3 M) at -20 C was added a solution of iPrMgCl (2M in THF, 20.4 mL, 40.8 mmol) dropwise. The mixture was stirred for 10 min and then warmed to 0 C and stirred an additional 50 min. Copper iodide (1.49 g, 7.84 mmol) was added, and the mixture was stirred for 10 min. Ethyl 2-(bromomethyl)acrylate (6.36 g, 4.55 mL, 32.9 mmol) was added, and the mixture was warmed to room temperature and stirred overnight. The reaction was quenched with sat. aq. NH4C1 (25 mL), diluted with EtOAc (25 mL) and extracted with EtOAc (3 x 30 mL). The combined organics were washed with brine (4 x 50 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The resulting residue was purified by silica gel column to give the desired product l-bromo- 3,5-difluoro-2-(2-methylallyl)benzene as a colorless and clear oil (10 g). Yield >95%.

The synthetic route of 175278-11-2 has been constantly updated, and we look forward to future research findings.

Related Products of 90347-66-3, These common heterocyclic compound, 90347-66-3, name is Methyl 3-iodo-4-methylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-iodo-4-methylbenzoic acid. Methyl-3-Iodo-4-methylbenzoate (3 g, 109 mmol, 1 eq) dissolved in MeOH (30 ml) was added sodium hydroxide (1.3 g, 327 mmol, 3 eq) followed by the addition of water (15 ml). The above solution was stirred at room temperature for 14 h. The solution was concentrated under vacuum, and then added water. The pH of the reaction was bought to 3 using Cone. HCl. The solid obtained was filtered and dried under vacuum, Yield: 2.7 g (96 %). 1HNMR (400MHz, DMSO-d6): delta 2.44 (s, 3H), 7.45 (d, 7- 8.00 Hz ,1H), 7.85 (d, J= 3.18 Hz, IH), 8.31 (s, IH).

Statistics shows that Methyl 3-iodo-4-methylbenzoate is playing an increasingly important role. we look forward to future research findings about 90347-66-3.

Related Products of 627-32-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 627-32-7, name is 3-Iodo-1-propanol belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 1 -(4-hydroxyphenyl)-3 -methyl-i H-pyrazole-4-carbaldehyde (214 mg, 1.057 mmol, 1 eq.), 3-iodopropan-i-ol (1.27 g, 1.268 mmol, 1.2 eq), K2C03 (292 mg, 2.114 mmol, 2 eq.) in 5 mL CH3CN was heated at reflux for 24 h. The mixture was thenfiltered, and the remaining solid was washed with EtOAc twice (10 mL each time). The organic layers were concentrated and purified using silica column chromatography to afford 1 -(4-(3 -hydroxypropoxy)phenyl)-3 -methyl-i H-pyrazole-4-carbaldehyde as a yellow solid (190 mg, yield: 69%). ?H NIVIR (CDC13) oe (ppm) 2.04-2.12 (m, 2H), 2.55 (s, 3H), 3.86-3.90 (t, 2H), 4.15-4.19 (t, 2H), 7.03 (d, J= 9.0 Hz, 2H), 7.34 (d, J= 9.0 Hz,2H), 8.03 (s, 1H), 9.96 (s, 1H); ?3C NIVIR (CDC13) oe (ppm) 11.55, 31.88, 59.94, 65.77,114.97, 121.48, 126.74, 131.18, 142.13, 143.41, 159.13, 184.94;ESI-MS(M+H)m/z=261.0.

The synthetic route of 3-Iodo-1-propanol has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19230-50-3, name is 2-Iodo-5-nitrobenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Iodo-5-nitrobenzoic acid

H. 2-Iodo-5-Nitroso-Benzamide The synthesis of 2-iodo-5-nitroso-benzamide can be performed similarly to the synthesis of 4-iodo-3-nitroso-benzamide, described above, using 2-iodo-5-nitro benzoic acid (Chemica Alta Ltd., Edmonton, Alberta, Canada) as the starting material.

The synthetic route of 19230-50-3 has been constantly updated, and we look forward to future research findings.