Category: iodides-buliding-blocks

Related Products of 13194-69-9, The chemical industry reduces the impact on the environment during synthesis 13194-69-9, name is 2-Iodo-5-methylaniline, I believe this compound will play a more active role in future production and life.

General procedure: 2-Iodoaniline 2a (65.7 mg, 0.3 mmol), Cu(OAc)2 (6 mg, 10%), KOtBu (101 mg, 0.9 mmol), DMAc (1.0 mL) were mixed in a Schlenck tube and then to the mixture was added 2-(phenylethynyl)benzonitrile1a (74 mg, 0.36 mmol) under N2. The reaction mixture was stirred for 12 h at 120 C under N2. After the reaction was completed (monitored by TLC), the reaction mixture was then diluted with water and extracted with ethyl acetate. After the combined organic layers were washed with brine, dried over Na2SO4, and concentrated under reduced pressure, the residue was purified by flash column chromatography on silica gel using petroleum ether/ethyl acetate as eluent to afford the pure product 3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodo-5-methylaniline, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 2468-56-6, name is 6-Iodohex-1-yne, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2468-56-6, Product Details of 2468-56-6

A mixture of 4,4?-bipyridine (1.0 g, 6.4 mmol) and 6-iodo-1-hexyne (4.6 g, 22 mmol)in dry MeCN (30 mL) was heated at 105 oC / 6 psi under N2 for 3 h. The reaction mixture was cooled to room temperature and the resulting reddish precipitate was filtered and washed thoroughly with MeCN. The solid was dissolved in H2O (100 mL), followed by the addition of excess of NH4PF6, resulting in the precipitation of an off-white solid which was collected by centrifugation, washed with H2O (3 × 20 mL), MeOH (1 × 20 mL) and dried in vacuo to yield HV?2PF6 as a light brown solid (2.4 g) in 62% yield

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Iodohex-1-yne, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 391211-97-5, name is 3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid

EXAMPLE 6 1-F3, 4-DIFLUORO-2- (2-FLUORO-4-VINVIPHENYLAMINO)-PHENVLL-2-HYDROXV-ETHANONE Step A: Synthesis of R3, 4-DIFLUORO-2- (2-FLUORO-4-IODOD-PHENYLAMINO)-PHENVLL- methanol. To 3, 4-DIFLUORO-2-(2-FLUORO-4-IODO-PHENYLAMINO)-BENZOIC acid (10. 0g, 25. 4MMOL) in tetrahydrofuran was added, borane in tetrahydrofuran (38.2mL of a 1. OM solution) after 16 hours stirring at room temperature, the reaction was complete and quenched by careful addition of 2% HCI (100ML). The mixture was stirred for 1 H, brine was added and the organic layer was separated which was dried and evaporated to give a colorless solid (7. 13g 74%) that was recrystalized from hot dichloromethane/hexane to give an analytical sample. MS (APCI+) 380 (M+1+) ; H NMR (400mHz, DMSO) 7.62 (s, 1H), 7.50 (d, 1H), 7.24 (m, 3H), 6.29 (d of t, 1 H), 5.35 (t, 1 H), 4.42 (d, 1 H).

According to the analysis of related databases, 391211-97-5, the application of this compound in the production field has become more and more popular.

Electric Literature of 103440-52-4, The chemical industry reduces the impact on the environment during synthesis 103440-52-4, name is Methyl 2-Iodo-5-methylbenzoate, I believe this compound will play a more active role in future production and life.

Step B: Pd(PPh3)4 (523 mg, 0.45 mmol) was added to a rt solution of methyl 2-iodo-5- methylbenzoate in toluene (23 mL). After the solution was stirred for 10 min, a solution of phenylboronic acid (1 .24 g, 9.96 mmol) in EtOH (10 mL) was added, followed by 2M aq. Na2C03 (21 mL). The mixture was vigorously stirred and heated to reflux for 24h. The rxn mixture was allowed to reach rt, then Et20 was added and the org. layer was separated and concentrated in vacuo. Purification by FC (Biotage SP1 : EtOAc/hept eluting with a gradient of 0-10% EtOAc) was performed to give methyl 4-methyl-[1 , 1 ‘-biphenyl]-2-carboxylate as a colorless oil. LC-MS A: tR = 0.94 min; [M+H]+ = 227.16.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-Iodo-5-methylbenzoate, other downstream synthetic routes, hurry up and to see.

Electric Literature of 444-29-1, A common heterocyclic compound, 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene, molecular formula is C7H4F3I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of aryl halides (0.5 mmol), aryl sulfinates (0.75 mmol), Pd(dppf)Cl2 (2.5 mol percent), P(OPh)3 (5 mol percent), K2CO3 (1.5 mmol) and 2 mL of DMF in a schlenk tube was heated to 150 °C under inert atmosphere (24 h for aryl iodides and 26 h for aryl bromides). The reaction mixture was cooled to room temperature, diluted with ethyl acetate and filtered through a plug of Celite. The filtrate was washed sequentially with H2O and brine. The organic layer was separated, dried (Na2SO4), and concentrated under vacuum. The crude product was purified by column chromatography (silica gel; petroleum ether). All the products were analyzed by GC-MS. 1H NMR, 13C NMR and IR of only representative products are given, as all the products are highly reported.

The synthetic route of 444-29-1 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 82998-57-0, name is 3-Iodo-4-methylbenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Safety of 3-Iodo-4-methylbenzoic acid

To the flask was added 250 ml of thionyl chloride and 26.2 g of 3-iodo-4-methylbenzoic acid, stirred and heated under reflux for 6 h,After drying under reduced pressure, dry dichloroethane was added and the solvent was removed under reduced pressure.Followed by adding 250 ml of chloroform, 20 ml of diisopropylethylamine,A solution of 24.1 g of 3- (4-methylimidazol-1-yl) -5-trifluoromethylaniline, and the temperature was raised to 60 C for 5 h.After completion of the reaction, the solvent was concentrated under reduced pressure to remove the solvent. Add ethyl acetateEster 200ml dissolved, washed 3 times, dried and concentrated, the resulting solid separation by column chromatography, eluentDichloromethane / methanol = 9, the desired fractions were collected and concentrated to give 28 g of a solid in 57% yield.

According to the analysis of related databases, 82998-57-0, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2043-57-4 as follows. Recommanded Product: 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane

In the first step, a fluorinated phosphonium salt was synthesized by reacting TPP and 2-perfluorohexyl ethyl iodide accordinto literature procedures [38,39]. Briefly, the fluorinated phosphonium salt was prepared by reacting TPP and fluoroalkyl iodide at 95 C in the absence of solvent. The reaction was continued for 24 h until all of the mixture was solidified. After cooling the resulting solid was washed several times with toluene and ether respectively. Then the white solid was dried at 50 C under vacuum.

According to the analysis of related databases, 2043-57-4, the application of this compound in the production field has become more and more popular.

Application of 260355-20-2,Some common heterocyclic compound, 260355-20-2, name is 1-Chloro-4-iodo-2-(trifluoromethyl)benzene, molecular formula is C7H3ClF3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The 1-chloro-4-iodo-2-trifluoromethylbenzene (10 mmol) obtained in the reaction 1.2 was dissolved in 20 ml of toluene, and the system was sequentially added with isoxazol-4-amine (12 mmol), palladium acetate ( 0.5 mmol), 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (12 mmol), 3 ml of triethylamine. After stirring for 10 minutes, add 10 ml of cesium carbonate (10 mmol). The aqueous solution is heated to 50 C for 4 hours. After the reaction is completed, 20 ml of water is added to the system, stirred for 20 minutes, and the organic phase is dried over anhydrous sodium sulfate, concentrated, and then purified by flash column chromatography.2.2 g of yellow N-(4-chloro-3-trifluoromethylphenyl)-isoxazole-4-amine powder was obtained in a yield of 84%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Chloro-4-iodo-2-(trifluoromethyl)benzene, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C8H6IN

1L pressure kettle,121.5 g (0.5 mol) of p-iodophenylacetonitrile,800 g (2 mol) of 10% sodium hydroxide,10.9 g (0.075 mol) of 8-hydroxyquinoline,12.8g (0.075mol) after adding copper chloride, the kettle heated to 50 ~ 55 , to maintain The pressure of the reactor is 0MPaG, the temperature of the reaction system is kept between 50 and 55 DEG C, and the reaction is carried out for 7 hours. The reaction solution is finished and the reaction vessel is cooled. The pH of the reaction solution is adjusted to between 7 and 8 with 36% hydrochloric acid. The mother liquor was adjusted to pH with 30% NaOH13 ~ 14, get dark red transparent liquid, sodium p-hydroxyphenylacetate solution, weighing 755g, the detection of p-hydroxyphenylacetic acid content of 9.79%, the yield was 97.3%.

According to the analysis of related databases, 51628-12-7, the application of this compound in the production field has become more and more popular.

1878-69-9, name is 2-(3-Iodophenyl)acetic acid, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C8H7IO2

To a solution of 3-iodorhohenylacetic acid (24.8 g, 94.6 mmol) in CH2Cl2 (200 mL) was added oxalyl chloride (189 mmol, 2 equiv), followed by a drop of DMF. The mixture was stirred at room temperature for Ih and then concentrated. Addition of ethanol and purification by flash chromatography (EtOAc/Hex) gave yellow oil as product. 1H NMR (600 MHz, CDCl3): delta = 7.63 (s, 1 H), 7.59 (d, 1 H), 7.25 (d, 1 H), 7.04 (t, 1 H), 4.16 (q, 2 H), 3.53 (s, 2 H), 1.25 (t, 3 H); LRMS: m+1 (291.0, 4.228 min.).

The synthetic route of 1878-69-9 has been constantly updated, and we look forward to future research findings.