Tag: M.W=200-300

Adding a certain compound to certain chemical reactions, such as: 133232-56-1, name is 3-Iodo-2-methylbenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 133232-56-1, Computed Properties of C8H7IO2

To a solution of compound 2 (63.0 g, 0.24 mol) in MeOH (300 mL) was added dropwise a freshly prepared solution of SOCI2 (52 mL, 0.72 mol) in MeOH (100 mL) at 0 0C. The mixture was heated to reflux for 3 hours. TLC (petroleum ether: ethyl acetate = 10:1) showed the reaction was complete, then the mixture was concentrated in vacuo. The residue was purified by column chromatography (petroleum ether) to afford compound 3 (60 g, 92%) as brown oil. 1H NMR (400 MHz, CDCI3): delta 7.94-7.96 (d, J = 8.0 Hz, 1 H), 7.71-7.73 (d, J = 8.0 HzJ H), 6.87- 6.91 (t, J = 8.0 Hz, 1 H), 3.88 (s, 3H), 2.65 (s, 3H).

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Related Products of 42048-11-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 42048-11-3 name is 2-Chloro-6-iodotoluene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Specific operation: In a 25 mL reaction flask equipped with a magnetic stirrer, a metal catalyst palladium acetate (6.7 mg, 0.03 mmol), triphenylphosphine (20.0 mg, 0.075 mmol) was added,S-2-bromophenyl-S-methyliminosulfanone (70.0 mg, 0.3 mmol), norbornene (56.4 mg, 0.6 mmol), potassium carbonate (82.8 mg, 0.6 mmol),Protect with nitrogen (at least three nitrogen cycles), add acetonitrile (3 ml) and 2-chloro-6-iodotoluene (90.9 mg, 0.36 mmol) successively in a nitrogen stream and close the vessel.The reaction solution was heated to 80 C. for about 12 h, and the reaction was complete by TLC.After the treatment, the reaction solution was first diluted with 15 ml of ethyl acetate, and then the inorganic substances such as the catalyst and the alkali were removed by suction filtration through a sand funnel containing silica gel.The resulting filtrate was separated by flash column chromatography to give the pure product 8-chloro-5,7-dimethyldibenzo[c,e][1,2]thiazine-5-oxide compound 3i. Yield: 45%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-6-iodotoluene, and friends who are interested can also refer to it.

Related Products of 172681-47-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 172681-47-9, name is 2-Amino-6-iodotoluene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a mixture of 3-iodo-2-methylbenzenamine (4.45 g, 19.1 mmol, 1.0 equiv), bis(pinacolato)diboron (5.80 g, 22.91 mmol, 1.2 equiv), and potassium acetate (5.60 g, 57.3 mmol, 3.0 equiv) in DMSO (70 mL), was added dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct (421 mg, 0.573 mmol, 0.03 equiv). The mixture was heated at 80 C. until the starting material was consumed. The solvent was removed in vacuo and the residue taken up in EtOAc (ca. 200 ml) and washed with water and brine. After drying with Na2SO4 and concentrating in vacuo, the residue was purified by silica gel chromatography (3:1 hexanes:EtOAc to 1:3 hexanes:EtOAc) to provide 2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine. MS (M+H+) 234; Calculated for C13H20BNO2: 233.2

The synthetic route of 2-Amino-6-iodotoluene has been constantly updated, and we look forward to future research findings.

Related Products of 5469-33-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5469-33-0, name is (Iodomethyl)cyclohexane, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE J-1 Procedure for Preparation of 4(5)-cyclohexylmethyl-1H-imidazole: Procedure- 2-Tert-butyldimethylsilyl-1-dimethylsulfamoyl imidazole (1) (4.1 g, 14.2 mmol) is taken up in 47 mL of anhydrous THF and cooled to -20 C. n-BuLi (8.9 mL, 14.2 mmol) is added dropwise to the solution of (1). The resultant solution is stirred at -20 C. for 45 min. Cyclohexylmethyl iodide (2) (3.14 g, 14 mmol) is then added dropwise to the reaction mixture. Then reaction is warmed to rt and stirred overnight. The next day the reaction is quenched with saturated ammonium chloride and diluted with water. The mixture is extracted with ethyl acetate (3*100 mL). The organic layers are combined and washed with water followed by brine. The organic phase is dried over sodium sulfate and the solvent removed under reduced pressure. Flash chromatography (4:1 ethyl acetate/hexane) affords 2.26 g (5.6 mmol) of 5-cyclohexylmethyl-2-tert-butyldimethylsilyl-1-dimethylsulfamoyl imidazole (3).

The chemical industry reduces the impact on the environment during synthesis (Iodomethyl)cyclohexane. I believe this compound will play a more active role in future production and life.

Related Products of 26260-02-6, A common heterocyclic compound, 26260-02-6, name is 2-Iodobenzaldehyde, molecular formula is C7H5IO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Was added 2-iodo-benzaldehyde (1.0 mmol) in a round bottom flask, acetonitrile (2ml), trimethylsilyl azide (3.0mmol), stirred for 1-2 min at 80 deg.] C in a heating block, then added CuBr2(2.0mmol), and then the system was sealed and heated at 80 , 3 hours, and extracted with ethyl acetate, after completion of the reaction, was concentrated by a simple column chromatography (eluent petroleum ether (60 ~ 90 ) and a mixed solvent of ethyl acetate) to give the product 2-iodo-benzonitrile, 68% yield.

The synthetic route of 26260-02-6 has been constantly updated, and we look forward to future research findings.

Related Products of 52914-23-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52914-23-5, name is 2-(4-Iodophenyl)ethanol, This compound has unique chemical properties. The synthetic route is as follows.

Into a 50-mL 3-necked round-bottom flask under N2 was placed a solution of 2- (4-iodophenyl)ethanol (470 mg, 1.90 mmol) in tetrahydrofuran (10 mL). Sodium hydride (91 mg, 3.8 mmol, 1.2 equiv.) was added at 0 0C. The mixture was warmed to room temperature and stirred at room temperature for 2 h. Benzyl bromide (272 muL, 3.9 mmol, 1.2 equiv.) and tetra-w-butylammonium bromide (61 mg, 0.19 mmol, 0.10 equiv.) were added at room temperature. The resulting solution was stirred for 20 h at room temperature. The reaction was then quenched by the addition of 10 mL of aqueous NH4CI. The solution was extracted with 3 x 60 mL of EtOAc, and the organic layers were combined and washed with 50 mL of brine. After evaporation, the residue was applied onto a silica gel column, and the product was eluted with EtO Ac/petroleum ether 1:20 to furnish 600 mg (94%) of l-[2- (benzyloxy)ethyl]-4-iodobenzene as a white solid.

The chemical industry reduces the impact on the environment during synthesis 2-(4-Iodophenyl)ethanol. I believe this compound will play a more active role in future production and life.

Synthetic Route of 52914-23-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52914-23-5 name is 2-(4-Iodophenyl)ethanol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of N,N(-bis(tert-butoxycarbonyl)-S-methylisothiourea (937 mg, 3.2 mmol), triphenylphosphine (5.0 g, 18 mmol) and 2-[(4-iodophenyl)ethyl]alcohol (1a, 800 mg, 3.2 mmol) were stirred in anhydrous THF (16 mL) at room temperature under nitrogen atmosphere. DIAD (3.8 ml, 18 mmol) was slowly added to reaction mixture and reaction was stirred at room temperature for 24 h. The reaction mixture was filtered through a Celite pad with washing CH2Cl2 and the solvent was removed under reduced pressure. The residue was purified by flash column chromatography (silica gel, 5% ethyl acetate in hexane) to afford the product 2 (1.1 g, 66%) as a colorless oil; 1H NMR (400 MHz, CDCl3) (7.61 (d, J = 8.4 Hz, 2H), 6.98 (d, J = 8.0 Hz, 2H), 3.72-3.64 (m, 2H), 2.96-2.88 (m, 2H), 2.37 (s, 3H), 1.51 (s, 9H), 1.48 (s, 9H); 13C NMR (100 MHz, CDCl3) (162.7, 158.0, 151.8, 138.2, 137.7, 131.1, 91.8, 82.7, 82.1, 50.1, 34.9, 28.2, 28.1, 15.8; HRMS (FAB) calcd for C20H30IN2O4S (M+) 521.0971, found 521.0966.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(4-Iodophenyl)ethanol, and friends who are interested can also refer to it.

Related Products of 447464-03-1, A common heterocyclic compound, 447464-03-1, name is 2-Fluoro-3-iodobenzoic acid, molecular formula is C7H4FIO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0459] A solution of Example 73a (3.0 g, 11.2 mmol) and KBr03 (3.7 g, 22.0 mmol) in 15 mL of cone. H2S04. The reaction mixture was stirred for 2 h at 90C; LC-MS (BD01052-127) analysis showed Example 73a was consumed; the mixture was poured into 250 mL water and stirred for 10 min. The mixture was extracted with EA (250 mL * 3). The combined organic phase was dried over Na2S04, filtrated and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography to give the desired product (Example 73b, 3.5 g, yield: 65%) as a yellow solid.LCMS [M+l]+ = 344.0

The synthetic route of 447464-03-1 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 117832-17-4 as follows. COA of Formula: C8H10IN

General procedure: To a two-necked round-bottomed flask fitted with a guard tube, PBr3 (2.7mmol, 0.26 mL), DMF (3 mmol, 0.23 mL) and chloroform (0.80 mL) were added, allowed to cool to 0 C and stirred for 0.5 h. After formation of colourless solid complex, 2-Iodo-4-methyl-phenylamine 2b (1 mmol) in chloroform (5 mL) was added and the reaction mixture was allowed to stir at r.t. for another 1-2 h. After completion, the reaction mixture was neutralized by adding saturated NaHCO3 solution and then extracted with DCM (3X 20 mL). Combined organic layer was washed with brine and dried over Na2SO4. The solvent was evaporated under reduced pressure and the crude product was purified through column chromatography using silica gel (60-120 mesh) and petether/EtOAc (5:1) as eluent.

According to the analysis of related databases, 117832-17-4, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 29289-13-2, name is 2-Iodo-4-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 29289-13-2

General procedure: A mixture of 2-iodoaniline (0.5 mmol), isothiocyanate (0.6 mmol), CuO nanoparticles (0.05 mmol), and Cs2CO3 (1.5 mmol) in PEG-400 (3mL) was stirred at 80C for 8h (Scheme 1). After the reaction, the reaction mixture was centrifuged and catalyst was separated from the reaction mixture and then followed by washing with ethyl acetate and acetone, dried in vacuo and used directly for further catalytic reactions. The cooled solution was partitioned between ethyl acetate and water, and the organic layer was washed with water and brine, and then dried over Na2SO4. After the removal of the solvent in vacuo, the residue was purified by silica-gel chromatography to give the desired N-substituted-2-aminobenzothiazoles. All the compounds were characterized by comparison with authentic samples [41].

The synthetic route of 2-Iodo-4-methylaniline has been constantly updated, and we look forward to future research findings.