Tag: M.W=200-300

Synthetic Route of 19099-54-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19099-54-8, name is 1-Iodo-2-isopropylbenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 7-(2-isopropyl)-phenylamino-9,9-diethylfluorene-2-nitrile (7.6 g, 19.97 mmol), 2-isopropyliodobenzene (24.88 g, 101 m·mol), copper powder (3.13 g, 49.25 mmol), potassium carbonate (12.71 g, 92 mmol), 18-crown-6 (0.34 g, 1.29 mmol) and xylenes (5 mL) was held at 165-175 C. for 19 hours cooled, diluted with toluene and filtered. The filtrate was washed with water, dried and concentrated. The residual liquid (27.15 g) was chromatographed over silica gel, and elution with 3:1 heptane-toluene recovering first the unreacted iodobenzene. The product came out in 1:1 and 65% toluene-heptane eluates, and was recrystallized from isopropanol, 6.82 g (68%), m.p. 179.2-180.4 C. Mass spec: m/z 498 (M+). Analysis: Calcd for C36H38N2: C, 86.70; H, 7.68 and N, 5.62%. Found: C, 86.61; H, 7.68, and N, 5.41%. 1H NMR (CDCl3) delta ppm: 0.27 (t, 6H, 7.32 Hz), 1.04 (d, 12H, 6.36 Hz), 1.89 (m, 4H), 3.26 (q, 2H, 6.6 Hz), 6.67 (m, 2H), 6.97 (d, 2H, 7.64 Hz), 7.17 (m 2H), 7.21 (m, 2H), 7.35 (dd, 2H, 1.28 and 7.72 Hz), 7.49 (t, 2H, 5 Hz), 7.54 (m, 2H). 13C NMR delta ppm: 8.32, 23.48, 27.42, 32.44 and 56.36 (5 sp3C), 108.15, 118.98, 120.14, 121.15, 125.87, 126.07, 126.73, 127.59, 128.36, 131.39, 132.18, 145.37, 146.37, 149.96, 151.91 and 152.55 (16 sp2 and sp C).

The synthetic route of 1-Iodo-2-isopropylbenzene has been constantly updated, and we look forward to future research findings.

Reference of 364-75-0,Some common heterocyclic compound, 364-75-0, name is 1-Fluoro-4-iodo-2-nitrobenzene, molecular formula is C6H3FINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-FLUORO-3-NITRO-1-CYCLOPROPYLBENZENE was prepared FROM 2-FLUORO-5-IODO-1- nitrobenzene and tricyclopropylindium according to the method described in J. Am. Chem. Soc. 2001,123, 4155-4160.

The synthetic route of 364-75-0 has been constantly updated, and we look forward to future research findings.

Related Products of 19718-49-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19718-49-1 name is Methyl 4-amino-3-iodobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of methyl 4-amino-3-iodobenzoate (100 mg,0.36 mmol) and triethylamine (101 mu, 0.72 mmol) in DCM (3 ml) was added dropwise to a cooled (0 C) solution of trifluoroacetic acid anhydride (127 mu, 0.90 mmol) in DCM (1 ml). The cooling bath was removed and the mixture was stirred for 1.5 h. The crude product was poured into cold water and DCM was added. The phases were separated; solvents were removed in vacuo and the crude product taken to the next step without further purification. Yield: 129 mg (96%); white solid. MS (ESI+) m z 374 [M+H]+. HPLC purity: 96%. 1H NMR (600 MHz, CDC13) delta ppm 8.51 (d, J=1.83 Hz, 1 H) 8.47 (br. s., 1 H) 8.36 (d, J=8.54 Hz, 1 H) 8.08 (dd, J=8.85, 1.83 Hz, 1 H) 3.93 (s, 3 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4-amino-3-iodobenzoate, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31599-61-8, Recommanded Product: 31599-61-8

14 Typical procedure for the preparation of 4,5-disubstituted-1,2,3-(NH)-triazoles (synthesis of 3a): A round-bottom sidearm flask (10 mL) containing PdCl2(PPh3)2 (0.015 mmol) was subjected to the Schlenk-line procedures of evacuation and purging of CO for three cycles. Iodobenzene and 4 equiv Et3N (1.2 mmol) were successively added, and the mixture was stirred at room temperature for 10 min, then 1-hexyne (0.45 mmol) was added, continuously stirred at room temperature for 14 h. Then NaN3 (35.1 mg, 0.54 mmol) and 1 mL DMSO were added to the mixture and the reaction continued at 45 C for 36 h. Following, to the reaction mixture was added water (2 mL), 20% HCl solution (1 mL) and extracted with ether (3 * 10 mL). The combined organic phases were washed with brine (2 * 5 mL), dried over anhydrous MgSO4 and concentrated in vacuo. The residue was subjected to flash column chromatography with hexanes/EtOAc (5/1) as eluent to obtain the desired 3a (56.33 mg, 82% yield). All products gave satisfactory spectroscopic and analytical data.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodo-1,2-dimethylbenzene, other downstream synthetic routes, hurry up and to see.

Related Products of 626-01-7, These common heterocyclic compound, 626-01-7, name is 3-Iodoaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-Aminophenol (6.0 g, 54.8 mmol), 3-iodoaniline (10.0 g, 45.7 mmol), picolinic acid (0.56 g, 4.6 mmol), copper(I) iodide and potassium phosphate (19.4 g, 91 mmol) were added to DMSO (100 mL) and the reaction mixture degassed by bubbling nitrogen into the mixture for 1 hour. The reaction flask was then placed into a preheated 80 C. oil bath and stirred for 15 hours before cooling to room temperature. The reaction mixture was then poured into 150 mL of water and extracted with 3×50 mL EtOAc. The combined organics were washed with 50 mL water, 50 mL brine, dried and evaporated. The crude oil was chromatographed on silica with 80/20 hexane/EtOAc (v/v) followed by 50/50 hexane/EtOAc (v/v) to give 7.2 g (79%) of 3,3?-oxydianiline as a white solid. The product was confirmed by GC/MS and NMR.

The synthetic route of 626-01-7 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3058-39-7, name is 4-Iodobenzonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C7H4IN

General procedure: FMMWCNTs(at)CPA(at)SMTU(at)PdII NPs (IV) (0.35 mol-%,0.015 g) were added to a mixture of triethylamine (NEt3) (2 mmol, 0.202 g), methyl acrylate (1.2 mmol, 0.108 mL), and iodobenzene (1.0 mmol, 0.203 g) in solvent-free conditions at room temperature. After the completion of the reaction (15 min)which was monitored by TLC, the nanocatalyst was separated by a magnetic field, washed with ethyl acetate, and dried at room temperature for 24 h to be used in the next run. The reaction mixture was then extracted with ethyl acetate (55 mL) and the combined organic layer was dried over anhydrous Na2SO4. After evaporation of the solvent, the crude product was purifiedby TLC (or column chromatography using n-hexane/ethylacetate (50 : 1)) using n-hexane/ethyl acetate (8 : 2) to produce the pure methyl cinnamate (0.153 g, 98% yield).

The synthetic route of 3058-39-7 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C3H4F3I

To a solution of 500 mg (1.79 mmol) of the compound from Ex. 35A in 22 ml of DMF were added 620 mg (4.49 mmol) of potassium carbonate, and the mixture was stirred at RT for 15 min. Then 1.24 g (5.39 mmol) of 1,1,1-trifluoro-3-iodopropane were added, and the mixture was stirred at 50 C. for 15 h. The DMF was very substantially distilled off and the residue obtained was partitioned between semisaturated sodium chloride solution (100 ml) and ethyl acetate (50 ml). The water phase was extracted with ethyl acetate. The combined organic phases were dried over sodium sulfate, filtered and concentrated. The residue obtained was chromatographed using a silica gel cartridge (Biotage, 100 g of silica gel, eluent: hexane/ethyl acetate 94:6?50:50). In this way, 600 mg (88% of theory) of the title compound were obtained. 1H-NMR (400 MHz, DMSO-d6, delta/ppm): 10.09 (s, 1H), 4.15 (br. d, 2H), 2.85-2.71 (m, 5H), 2.42 (dd, 1H), 1.17 (s, 3H), 1.06 (dd, 1H), 0.87 (s, 3H), 0.73 (dd, 1H). LC/MS (Method 4, ESIpos): Rt=1.32 min, m/z=375 [M+H]+.

The synthetic route of 460-37-7 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 116632-41-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 116632-41-8 name is 2-Chloro-5-iodotoluene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In a Schlenk tube are added 6-azaindole (0.846 mmol), potassium phosphate (1.78 mmol) and CuI(0.042 mmol). The tube is twice evacuated and back-filled with Ar. Toluene (1 ml), 2-chloro-5-iodotoluene (0.846 mmol) and (trans)-N,N’-dimethyl-1,2-cyclohexanediamine (0.085 mmol) are added. The tube is sealed and the reaction mixture is stirred for 22 h at 110 C. The reaction mixture is diluted with dichloromethane and dry loaded on silica gel to be purified by flash chromatography (hexane/EtOAc 10% to 30%) to give 1-(4-chloro-3-methylphenyl)-1H-pyrrolo[2,3-c]pyridine as a white solid (184 mg).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-5-iodotoluene, and friends who are interested can also refer to it.

Electric Literature of 25245-35-6, A common heterocyclic compound, 25245-35-6, name is 2-Iodo-1,4-dimethoxybenzene, molecular formula is C8H9IO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of the styrene (3 mmol), the halogenated benzene (3 mmol), triethanolamine (3 mmol) and Pd(II) acetate (0.03 g) was stirred under argon at 100 C for 24 h. The reaction was cooled to 25 C, quenched by the addition of dil. aq. hydrochloric acid (2 N, 10 ml), and extracted with ether (3 × 100 ml). The organic phases were dried (Na2SO4), the solvents evaporated, and the crude product subjected to chromatography (silica gel, hexane/ethyl acetate mixtures).

The synthetic route of 25245-35-6 has been constantly updated, and we look forward to future research findings.

Electric Literature of 52807-27-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52807-27-9, name is 4-Chloro-2-iodoanisole belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Under a nitrogen atmosphere, tris (dibenzylideneacetone) dipalladium (2.29 g, 2.5 mmol) , 1, V -bis (diphenylphosphi.no) ferrocene (2.11 g, 5 mmol) , sodium tert-butoxide (6.73 g, 70 mmol) and toluene (150 ml) were mixed. To this solution, 2-amino-3-bromo-5-methylpyridine (9.82 g, 52.5 mmol), 4-chloro-2-iodo-l-methoxybenzene (13.42 g, 50 mmol) and toluene (100 ml) were added. The mixture was stirred at an internal temperature of 9O0C for 2 hours. The reaction solution was cooled to room temperature, and IN hydrochloric acid (150 ml) was added thereto. The insoluble was filtered off and washed twice with toluene (50 ml) . The organic layer was separated and washed sequentially, once with 5N aqueous sodium hydroxide solution (50 ml) and twice with water (50 ml) . The organic layer was concentrated under reduced pressure, ethanol/acetone (4/1, 30 ml) was added to the concentrate, and the crystals were collected by filtration. The crystals were washed three times with ethanol/acetone (4/1, 15 ml) , and dried under reduced pressure at 50C, to yield the title compound (12.88 g) (yield 78.6%).1H-NMR (CDCl3, TMS, 300 MHz) delta (ppm) : 2.23 (3H, s) , 3.92 (3H, s), 6.77 (IH, d, J = 8.6 Hz), 6.87 (IH, dd, J = 2.5 Hz, 8.6 Hz), 7.59 (IH, d, J = 1.5 Hz), 7.75 (IH, brs) , 8.05 (IH, d, J = 1.0 Hz), 8.69 (IH, d, J = 2.5 Hz). 13C-NMR (CDCl3, TMS, 75 MHz) delta (ppm): 17.1, 56.2, 106.8, 110.4, 117.1, 120.1, 125.4, 126.0, 131.2, 140.9, 146.0, 146.3, 149.3.Mass analysis (Ci3Hi2N2OBrCl) Theoretical value: 326 Measured value: 327 [M+H]+Elemental analysis (Ci3Hi2N2OBrCl)Theoretical value: C, 47.66; H, 3.69; N, 8.55; Br, 24.39; Cl , 10 . 82Measured value: C, 47.94; H, 3.62; N, 8.68; Br, 24.36; Cl, 10.86Melting point: 140.2C

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-2-iodoanisole, other downstream synthetic routes, hurry up and to see.