Tag: M.W=200-300

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34683-73-3, name is 1-Chloro-6-iodohexane, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H12ClI

Example 6 Compound (6) is prepared as follows : Step 6. 1 : 5-(6-chlorohexyl)-2,2′-bithiophene; To a stirred solution of 2, 2′-bithiophene (10.0 g, 60.24 mmol) in anhydrous THF (150 mi) is added n-butyllithium (2.5 M in hexanes, 20.0 ml, 50.0 mmol) dropwise at-78 C under nitrogen. After complete addition, the mixture is allowed to warm to room temperature, with stirring, over 2 h, followed by the addition of 1- chloro-6-iodohexane (14.55 g, 50.0 mmol). The resultant mixture is stirred overnight at room temperature. The reaction is quenched with sat. aq. NH4Ci, and the reaction mixture is extracted with ethyl acetate (3 x 100 ml). The combined organic extracts are washed with water, brine, and dried over sodium sulphate. The solvent is removed under reduced pressure and the residue is purified by column chromatography on silica, eluting with petroleum ether, to give 5- (6- chlorohexyl)-2, 2′-bithiophene as a white solid (7.73 g, 54 %). H NMR (300 MHz, CDCl3) : 8 (ppm) 7.14 (d, J = 5.3 Hz, 1.3 Hz, 1 H, Ar-H), 7. 08 (dd, J = 3.5 Hz, 1.1 Hz, 1 H, Ar-H), 6.97 (m, 2H, Ar-H), 6.66 (d, J = 3.5 Hz, 1 H, Ar-H), 3.51 (d, J = 6.6 Hz, 2H, CICH2), 2.78 (t, J = 7.1 Hz 2H, ArCH2), 1.61-1. 81 (m, 4H, CH2), 1.35-1. 51 (m, 4H, CH2) ; MS (m/e) : 282 (M+, 2 %), 166 (8), 123 (39), 110 (22), 97 (100).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 13194-69-9,Some common heterocyclic compound, 13194-69-9, name is 2-Iodo-5-methylaniline, molecular formula is C7H8IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 25mL oven-dried Schlenk tube were added 2-iodoaniline 1a (110mg, 0.5mmol), phenylacetic acid 2a (81.7mg, 0.6mmol) or benzyl chloride 4a (75.9mg, 0.6mmol), selenium powder (118mg, 1.5mmol), CuBr (7.17mg, 10mmol%), KOH (56.1mg, 1.0mmol) or Cs2CO3 (326mg, 1.0mmol), DMSO (1.5mL). The tube was purged with nitrogen three times. Then the reaction mixture was stirred in a preheated oil bath at 120C for 18h. After the reaction was completed, the mixture was diluted with a saturated solution of Na2CO3 (15mL) and extracted with ethyl acetate (3×10mL). The organic layer was dried over anhydrous Na2SO4, then concentrated in vacuo. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate, 100/1) to give pure product 3aa.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Iodo-5-methylaniline, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 167479-01-8, name is tert-Butyl (3-iodopropyl)carbamate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 167479-01-8, COA of Formula: C8H16INO2

Compound 7?. A solution of 3-bromo-N-(tert-butoxycarbonyl)propylamine23 (1.61g; 5.66mmol) and cyclen glyoxal (1g; 5.15mmol) in freshly distilled THF (25mL) was stirred at room temperature for 3 days until completion, as monitored by TLC. The white powdery precipitate was filtered and washed with diethylether to afford compound 7? (2.25g; 91% yield). 1H NMR (D2O, 300MHz) delta: 3.99-3.45 (m, 9H), 3.33-3.21 (m, 6H), 2.98-2.79 (m, 5H), 2.63-2.47 (m, 2H), 2.21-2.02 (m, 2H, CH2CHNHBoc), 1.48 (s, 9H, C(CH3)3). 13C NMR (D2O, 75MHz) delta: 160.9 (CO), 86.7 (CHam), 84.2 (C(CH3)3), 74.6 (CHam), 64.9, 59.9, 58.9, 54.1, 51.3, 51.0, 50.6, 50.5, 46.5, 39.9 (CH2NHCO), 30.7 (CH2NHCO), 30.7 (C(CH3)3), 26.3 (CH2CH2NHCO). HRMS (ESI): calculated for C18H34N5O2+ [M]+: 352.27070; found: 352.27067.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (3-iodopropyl)carbamate, other downstream synthetic routes, hurry up and to see.

Related Products of 627-31-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 627-31-6 name is 1,3-Diiodopropane(stabilized with Copper chip), This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: K2CO3 (3.7g, 26.8mmol) was added to a solution of 3-(4-hydroxyphenyl)-thiazolidine-2,4-dione (10, 2.8g, 13.4mmol) in MeCN (20mL) and stirred for 10min. The appropriate diiodoalkane (80.3mmol) was added and the reaction mixture was stirred at 95C for 7h. After cooling, water (10mL) was added followed by extraction with ethyl acetate. The organic layer was dried over anhydrous MgSO4, filtered and evaporated under reduced pressure. The residue was purified by flash column chromatography (SiO2, n-hexane/ethyl acetate= 3/1 v/v) to afford the desired compounds.4.1.5 61 3-(4-(3-Iodopropoxy)phenyl)thiazolidine-2,4-dione (11a) (0021) White solid, yield: 81%, 4.0g, 1H NMR (400MHz, DMSO-d6) delta: 2.19-2.24 (m, 2H), 3.39 (t, J=6.6Hz, 2H), 4.06 (t, J=4.7Hz, 2H), 4.28 (s, 2H), 7.05 (d, J=7.1Hz, 2H), 7.20 (d, J=7.1Hz, 2H). HRMS (ES+): m/z calculated for C12H12INO3S: 399.9481 [M+Na]+. Found 399.9472.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3-Diiodopropane(stabilized with Copper chip), and friends who are interested can also refer to it.

Electric Literature of 351003-36-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 351003-36-6 as follows.

A solution of 2-fluoro-5-iodobenzonitrile (100 mg, 0.405 mmol) and 2-methyl- 2,4-dihydro-3H-pyrazol-3-one (63.6 mg, 0.648 mmol) in 5 ml_ of 1 -methyls- pyrrol id inone was treated with cesium carbonate (396 mg, 1.22 mmol) and stirred at 110 0C for 2 hour. The reaction was diluted with 50 ml_ water and extracted with 2 x 5OmL ethyl acetate. The combined organic layers were washed with 50 ml_ water, 5OmL brine, dried over magnesium sulfate, filtered, and evaporated to afford crude material. Purification by normal phase chromatography provided the title compound as a white solid (93 mg). LC/MS 5-100% acetonithle/tfa-water/tfa (6 min gradient) 4.74 min [(M+H)+ = 326]. 1 H NMR (400 MHz, DMSO- c/6) delta ppm 8.33 (1 H, d, J=2.2 Hz), 8.04 (1 H, dd, J=8.9, 2.2 Hz), 7.45 (1 H, d, J=2.0 Hz), 6.95 (1 H, d, J=8.9 Hz), 5.99 (1 H, d, J=2.0 Hz), 3.67 (3 H, s)

According to the analysis of related databases, 351003-36-6, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2142-70-3, name is 1-(2-Iodophenyl)ethanone, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-(2-Iodophenyl)ethanone

General procedure: To the mixture of o-bromoacetophenone derivatives 1 (1.0 mmol), t-BuOK (2.0 mmol, 2.0 equiv) and amines 2 (2.0 mmol, 2.0 equiv), dry 1,4-dioxane (5 mL) was added. The mixture was refluxed at 140 C under N2 without light for 16 h. The reaction was monitored by TLC. Then, the resulting reaction mixture was diluted with water (10 mL), eluting with EtOAc (3 * 15 mL). The organic layer was dried over anhydrous Na2SO4 followed by concentration under reduced pressure and purified by column chromatography using petroleum ether/ethyl acetate to afford the corresponding products.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, A new synthetic method of this compound is introduced below., category: iodides-buliding-blocks

To a mixture of 600 mg (4.0 mmol) of 3-methoxyphenylboronic acid, 792 mg (3.0 mmol) of 3,5-dimethoxyiodobenzene, 34 mg (5 mol %) palladium(II)acetate, 182 mg (20 mol %) of tri-o-tolylphosphine, and 3.6 g (24 mmol) of cesium fluoride was added 10 mL of anhydrous dioxane. The reaction was stirred at reflux under N 2 for 50 min, then poured into 30 mL of water and extracted with diethyl ether (3 10 mL). The combined ether layers were back extracted with saturated aqueous NaHCO 3 solution (1 10 mL), then brine (1 10 mL), dried over MgSO 4, filtered, and concentrated to an oil. This was purified via silica gel chromatography, eluting with 10%, ethyl acetate:hexanes to provide the titled compound (650 mg, 89%).

The synthetic route of 25245-27-6 has been constantly updated, and we look forward to future research findings.

Electric Literature of 2996-30-7, These common heterocyclic compound, 2996-30-7, name is 3-Fluoro-4-iodonitrobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 2-fluoro-1-iodo-4-nitrobenzene (1.96 g, 7.34 mmol), bis(pinacolato)diboron (1.86 g, 7.34 mmol), dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium (II) dichloromethane adduct (0.599 g, 0.734 mmol), and potassium acetate (2.38 g, 24.2 mmol) in DMSO (14.7 mL) in a seal-able tube was degassed with nitrogen for 15 min, sealed, and stirred at 100 C. for 2.5 h. The reaction mixture was cooled to room temperature, diluted with water and ethyl acetate, and filtered over Celite. The aqueous layer was separated and re-extracted with ethyl acetate. The combined organic layers were washed with brine, dried over magnesium sulfate, filtered, and concentrated to a brown oil. Purification by flash column chromatography using ethyl acetate in hexanes (0%-20%) gave the desired product (1.60 g, 81.6%).

The synthetic route of 2996-30-7 has been constantly updated, and we look forward to future research findings.

Electric Literature of 31599-61-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Pd cNPs/CFe3O4(20 mg, 0.73 mol%), aryl halide (0.5 mmol),phenylboronic acid (0.6 mmol), K2CO3(1.5 mmol), and EtOH (3 mL)were taken in a schlenk tube with a teflon stopcock, sealed andheated at 70C for a given time with constant stirring. For chloroderivatives, the reaction was performed using TBAB as additive(0.5 mmol), DMF (3 mL), at 110C and catalyst 40 mg (1.5 mol%).After the completion of reaction, the catalyst was separated by anexternal magnet and reaction mixture was washed with water toremove excess of boronic acids and further the mixture was sepa-rated by ethyl acetate. The solvent was evaporated and the residuewasresiduewas subjected to GC analysis (retention time of halobenzene wasused as the internal standard) followed by column chromatographyfor further purification. The purified compounds were character-ized by1H and13C NMR spectroscopy using CDCl3as solvent andTMS as internal standard. The spectral details and spectra are givenin supporting information section (Figs. S5-S24).

The synthetic route of 4-Iodo-1,2-dimethylbenzene has been constantly updated, and we look forward to future research findings.

Related Products of 3032-81-3,Some common heterocyclic compound, 3032-81-3, name is 1,3-Dichloro-5-iodobenzene, molecular formula is C6H3Cl2I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2,6-diamino-9H-purine-8- thiol (3.6 mmol), neocuproine hydrate (0.36 mmol), Cul (0.36 mmol), NaO-?-Bu (7.2 mmol), 1,3- dichloro-5-iodobenzene (10.8 mmol), and anhydrous DMF (24 mL) were taken in a round bottom flask flushed with nitrogen. The flask was sealed with Teflon tape, heated at 1 10 °C, and magnetically stirred for 20 h under nitrogen. Solvent was removed under reduced pressure and the resulting residue was chromatographed (CH2Cl2:MeOH:AcOH, 20: 1 :0.5). Obtained as a light yellow solid in 65 percent yield. MS (ESI): m/z 326.9 [M + H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,3-Dichloro-5-iodobenzene, its application will become more common.