Tag: M.W=200-300

Electric Literature of 25309-64-2, These common heterocyclic compound, 25309-64-2, name is 1-Ethyl-4-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a large microwave tube (Biotage, 10-20 mL) equipped with a stir bar was added Pd(OAc)2(23.4 mg, 0.10 mmol, 10 mol %), S-1 (400 mg, 1.04 mmol, 1 equiv), cesium pivalate (731 mg,3.12 mmol, 3 equiv), aryl iodide (2-3 equiv) and anhydrous tert-amyl alcohol (9.6 mL). The capwas crimped and the vessel was flushed with nitrogen. The microwave tube was heated withfollowing parameters: 1 min pre-stirring, followed by a ramp (normal) to 180 C and held attemperature for 30 to 50 min. Hydrazine (500 muL of 35% aqueous) was added to the reaction andallowed to stir at 60 C for 1 hr or at room temperature overnight. The tert-amyl alcohol wasremoved en vacuo and the remaining residue dissolved with EtOAc, filtered through a plug ofcelite, and concentrated en vacuo. The crude reaction was purified via flash columnchromatography with EtOAc/Heptanes.

Statistics shows that 1-Ethyl-4-iodobenzene is playing an increasingly important role. we look forward to future research findings about 25309-64-2.

101335-11-9, name is 2-Chloro-4-fluoro-1-iodobenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C6H3ClFI

7,7-Dimethyl-2-(pyridin-2-yl)-4,5,6,7-tetrahydrooxazolo[4,5-c]pyridine (460 mg, 2.0 m mol), Pd2(dba)3 (92 mg, 0.1 mmol), X-phos (95 mg, 0.2 mmol), 2-chloro-4- fluoro-1-iodobenzene (768 mg, 3.0 mmol), and Na-OtBu (576 mg, 6.0 mmol) were combined in toluene (15 mL) and heated at 1500C by microwave for 3 h. The reaction was evaporated to dryness, diluted with dichloromethane and extracted with water. The combined organic layer was dried using sodium sulfate, filtered, evaporated, and then purified by prep-TLC to obtain the title compound as a yellow solid. (6 mg, 0.87 %). 1H NMR (400 MHz, CDCl3): delta 8.74-8.76 (m, IH), 8.08-8.11 (m, IH), 7.78-7.72 (m, IH), 7.32-7.36 (m, IH), 7.15-7.20 (m, 2H), 6.96-7.01 (m, IH), 4.06 (s, 2H), 3.12 (s, 2H), 1.46(s, 6H); LC/MS: m/e = 358 (M+H)+.

The synthetic route of 101335-11-9 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 6828-35-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6828-35-9 as follows.

General procedure: A mixture of 2-iodoaniline 1 (0.5 mmol) and Pd(OAc)2 (5.6 mg, 0.025 mmol, 5.0 mol%) in CH3CN (3 mL) was added into a Schlenk flask (25 mL) and stirred at room temperature. Followed by the addition of ethyl acrylate 2a (100 mg, 1.0 mmol, 2.0 equiv) and triethylamine (101 mg, 1.0 mmol, 2.0 equiv), the mixture was stirred at 100 C until the reaction was finished. Then the mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate, 5:1 to 2:1) afforded the corresponding alkenylanilines 3.

According to the analysis of related databases, 6828-35-9, the application of this compound in the production field has become more and more popular.

Reference of 19094-56-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19094-56-5, name is 2-Chloro-5-iodobenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The polyphosphoric acid (113 mL) was added to the three-necked flask, and the compound of formula 1b (28.25 g, 100 mmol) was added and heated to an inner temperature of about 50 C and stirred,Phenol (18.82 g, 200 mmol) was added,After heating, the temperature was raised to 80 to 85 C for 3 to 4 hours. After the reaction was cooled to 50 C, the reaction was slowly added dropwise (283 m), followed by addition of dichloromethane (169 mL)After the separation of the organic phase, the aqueous phase was extracted twice with methylene chloride (84 mL) and the combined organic phase saturated sodium bicarbonate (169 mL)The solution was washed once, washed twice with saturated brine (84 mL), dried over sodium sulfate, concentrated with a mixed solvent of dichloromethane ethanol Crystallization gave compound 2b (29.76 g, 83%).

The synthetic route of 2-Chloro-5-iodobenzoic acid has been constantly updated, and we look forward to future research findings.

Reference of 52570-33-9, These common heterocyclic compound, 52570-33-9, name is Methyl 3-iodo-2-methylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of methyl 3-iodo-2-methylbenzoate (5.20 g, 18.8 mmol) in CCI4 (90 mL) at RT was added N-bromosuccinimide (NBS) (4.02 g, 22.6 mmol) then the reaction flask was purged with N2. After the mixture was stirred at 85 C for 5 m, 2,2?-azobis(2- methylpropionitrile) (AIBN) (1.62 g, 9.42 mmol) was added. The mixture was stirred overnight at 85 C then concentrated. The residue was diluted with H2O and extracted with EtOAc. The organic phase was dried over Na2S04, filtered, and concentrated to give the crude product, which was purified using silica gel eluting with EtOAc in petroleum ether from 0% to 1% to afford methyl 2-(bromomethyl)-3-iodobenzoate (2.64 g, 40% yield) as a solid.

Statistics shows that Methyl 3-iodo-2-methylbenzoate is playing an increasingly important role. we look forward to future research findings about 52570-33-9.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 69113-59-3, name is 3-Iodobenzonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 69113-59-3

The title compound (39 mg, 67.3 %, yellow solid) was obtained from [4- (5-] tributylstannanyl-isoxazol-3-ylmethyl)-piperazine-1-carboxylic acid ethyl ester (106 mg, 0.2 mmol) and Pd (PPh3) [2C12] (0.2 mg) with 3-iodobenzonitrile (38.9 mg, 0.17 mmol) in dioxane [(LML)] at [110 C OVEMIGHT. LH-NMR] (CDC13) 8 (ppm): [8.] 07 (s, 2H), 8.02 (d, 1H), 7.73 (d, 1H), 7.62 (t, lH) 6.68 (s, [1H),] 4.14 (q, 2H), 3.68 (s, 2H), 3.51 (m, 4H), 2.51 (m, 4H) and 1. 26 (t, 3H).

The synthetic route of 69113-59-3 has been constantly updated, and we look forward to future research findings.

Related Products of 260558-15-4, The chemical industry reduces the impact on the environment during synthesis 260558-15-4, name is 4-Bromo-2-iodo-1-methylbenzene, I believe this compound will play a more active role in future production and life.

To a solution of 2-methyl-5-bromo-iodobenzene (12 g, 40.4 mmol) in tetrahydrofuran (75 ml), cooled to -78 C., was added a solution of isopropylmagnesium chloride (4.6 g, 44.5 mmol) in tetrahydrofuran (22.2 ml) dropwise over 20 minutes. After stirring at -78 C. for 30 minutes, the mixture was warmed slowly to -20 C. and stirred for 1 hour. After cooling again to -78 C., trimethylborate (8.4 g, 80.8 mmol) was added dropwise. After warming to 0 C., the mixture was stirred for 2 hours, treated with 1 M hydrochloric acid (35 ml), and extracted with ethyl acetate (2*50 ml). The combined extracts were washed with water (50 ml), dried over sodium sulfate, and concentrated under reduced pressure. The residual solid was suspended in hexane (50 ml), filtered, washed with hexane (30 ml) and dried under reduced pressure to provide 2-methyl-5-bromo-phenylboronic acid (7.32 g, 84% yield) as a white solid. 1H NMR (DMSO-d6) delta 7.92 (s, 1H), 7.46 (d, J=8.1 Hz, 1H), 7.13 (d, J=8.1 Hz, 1H), 2.59 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2-iodo-1-methylbenzene, other downstream synthetic routes, hurry up and to see.

Some common heterocyclic compound, 19230-28-5, name is 1,3-Dichloro-2-iodobenzene, molecular formula is C6H3Cl2I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 19230-28-5

General procedure: To a stirred solution of complex 1 (10 mg, 0.0125 mmol) in a mixed solvent of n-heptane (1.5 mL) and water (1.5 mL) were added KCN (10.6 mg, 0.1625 mmol), ZnCl2 (11.1 mg, 0.0825 mmol), NaBH4 (0.5 mg, 0.0125 mmol), and iodobenzene (26 mg, 0.125 mmol). The reaction mixture was stirred at 100 C for 1 h under nitrogen atmosphere. After cooling the reaction mixture in an ice-bath, aliquots of the organic layer were transferred to a vial with a Pasteur pipette. Eluting the aliquots with diethyl ether on a short glass-column (0.7 × 15 cm) packed with alumina (ca. 1 cm) resulted in a clear yellowish solution which was analyzed with GC/MS.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 19230-28-5, its application will become more common.

Some common heterocyclic compound, 167479-01-8, name is tert-Butyl (3-iodopropyl)carbamate, molecular formula is C8H16INO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H16INO2

Step B: Methyl 2-(5-(bis(tert-butoxycarbonyl amino -4-phenylpyrimidin-2-yl -5-((tert- butoxycarbonyl)amino)pentanoateTo a mixture of 2-((5-(bis-ter?-butoxycarbonyl)amino-4-phenylpyrimidin-2-yl)) acetate (300 mg, 0.676 mmol) and tert-butyl (3-iodopropyl) carbamate (231 mg, 0.812 mmol) in THF (6 mL) at 25 C was added potassium 2-methylpropan-2-olate (1.35 mL, 1.35 mmol). The resulting mixture was stirred at 25 C for 12 h then partitioned between water (30 mL) and EtOAc (30 mL x 3). The combined organic layers were dried over a2S04 and concentrated to give the title compound. MS: m/z = 601.4 (M + 1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 167479-01-8, its application will become more common.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 21304-38-1 as follows. Formula: C6H7IN2

A solution of 4-iodo-benzene-l,2-diamJne (0.46g, 1.96mmol), ethanedial [40% in water] (2.25mL), acetic acid (ImL) and ethanol (2OmL) were heated to 1000C for several hours and then cooled to room temperature. Water was added and the crude product was extracted with ethyl acetate. The product was purified via silica gel column chromatography with hexane: ethyl acetate (1:1) to give 0.323g (64%) of 6- iodo-quinoxaline. 1H NMR (400 MHz, CDCl3) S 8.77 (dd, 2H, J=2.0, 8.8Hz), 8.46 (d, IH, 2.0Hz), 7.96 (dd, IH, J=2.0, 8.8Hz), 7.75 (d, IH, J=8.8Hz).

According to the analysis of related databases, 21304-38-1, the application of this compound in the production field has become more and more popular.