Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 825-98-9, name is 3-Fluoro-4-iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H4FIO2
To a solution of 3-fluoro-4-iodobenzoic acid (step-lof Intennediate-27, 1.0 g, 3.75 mmol) inDCM (20.0 mL) was added oxalyl chloride (947 mg, 7.57 mmol) and stirred at ft for 3-4 h.Meanwhile, to a solution of 2-(dimethylamino)ethanol (501 mg, 5.63 mmol) in THF (20.0 mL)was added Et3N (759 mg, 7.51 mmol) and stirred for 5-10 mins followed by addition of aboveprepared acid chloride solution. The reaction mass was stirred at rt for 16 h before it wasquenched with water and extracted with DCM. The organic layer was concentrated to afford400 mg of title product. ?H NMR (300 MHz, DMSO-d6): 10.54 (br s, 1H), 8.08-8.03 (t, J =7.8 Hz, 1H), 7.95-7.91 (d, J = 9.3 Hz, 1H), 7.68-7.66 (m, 1H), 4.59 (t, 2H), 3.50 (br s, 2H),2.84 (s, 6H); MS [M+Hj: 338.
According to the analysis of related databases, 825-98-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; MUTHUKAMAN, Nagarajan; PISAL, Dnyandeo; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy Manish; KADAM, Sheetal R; (303 pag.)WO2016/55947; (2016); A1;,
Iodide – Wikipedia,
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