Reference of 460-37-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 460-37-7 name is 1,1,1-Trifluoro-3-iodopropane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
: in a 100 ml dry single-mouth flask, isopropyl 2-bromo-6-methyl-5-(1-(piperazine-1-ethyl)ethyl)indolizine-7-carboxylate hydrochloride (170 mg, 0.38 mmol) was dissolved in N,N-dimethylformamide (10 mL), and 1,1,1-trifluoro-3-iodopropane (170 mg, 0.76 mmol), potassium carbonate (157 mg, 1.14 mmol) were added, the mixture was microwave-stirred at 100 C. for 2 hours, water was added, and extracted with ethyl acetate (50*3 mL). The combined organic phase was dried over anhydrous sodium sulfate, filtrated, and solvent was removed under reduced pressure to give a yellow oil (120 mg, 63%), MS (ESI) m/z 504 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,1,1-Trifluoro-3-iodopropane, and friends who are interested can also refer to it.
Reference:
Patent; SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; CHEN, Xuxing; GENG, Meiyu; JIANG, Lei; CHEN, Yi; CAO, Jianhua; JIANG, Qingyun; SHEN, Qianqian; DING, Jian; YAO, Yucai; ZHAO, Zhao; XIONG, Yuanfang; (247 pag.)US2019/211010; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com