455-13-0, name is 4-Iodobenzotrifluoride, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 455-13-0
General procedure: Step 1. To a solution of the arylhalide (1 equiv.) and propargyl alcohol (3 equiv.) in triethylamine (0.2 M) was added Pd(PPh3)4 (1 mol %) and CuI (5 mol %, dissolved in minimum necessary amount of triethylamine) under Ar. The resulting mixture was stirred at ambient temperature. After completion of the reaction, the reaction mixture was diluted with EtOAc and filtered through a short pad of SiO2 (eluent EtOAc). The filtrate was concentrated in vacuo and the crude products were purified by flash column chromatography on silica to afford the propargylic alcohol 13a – 13i.
The synthetic route of 455-13-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kristianslund, Renate; Aursnes, Marius; Tungen, J°rn Eivind; Hansen, Trond Vidar; Tetrahedron Letters; vol. 57; 47; (2016); p. 5232 – 5236;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com