Tag: M.W=200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 21304-38-1, name is 4-Iodobenzene-1,2-diamine, This compound has unique chemical properties. The synthetic route is as follows., name: 4-Iodobenzene-1,2-diamine

To the solution of (S)-2-tert-butoxycarbonylamino-3-methyl-butyric acid (0.33 g, 1.5 mmol), 4-iodo-benzene-1,2-diamine (0.35 g, 1.5 mmol) and diisopropylethyl amine (0.8 mL, 4.5 mmol) in N.N-dimethylformamide (6 mL) was added dropwise a solution of O-benzotriazol-1-yl-N,N, N’,N’-tetramethyluronium hexaflurorophosphate (0.71 g, 1.75 mmol) N,N-dimethylformamide (2 mL). The reaction mixture was stirred for 12 hours at room temperature. After adding aqueous sodium carbonate solution, the reaction mixture was extracted with ethyl acetate and the organic layer was washed with aqueous sodium carbonate solution and brine, dried over sodium sulfate, filtered, and concentrated to give a mixture of regioisomers, [(S)-1-(2-amino-4-iodo-phenylcarbamoyl)-2-methyl-propyl]-carbamic acid tert-butyl ester and [(S)-1-(2-amino-5-iodo-phenylcarbamoyl)-2-methyl-propyl]-carbamic acid tert-butyl ester (0.65 g, 100%).LC-MS: Calcd for C16H24IN3O3 [M+H+] 434, found 434.

According to the analysis of related databases, 21304-38-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chen, Shaoqing; Huby, Nicholas J.S.; Kong, Norman; Moliterni, John Anthony; Morales, Omar Jose; US2009/48452; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 877264-43-2, A common heterocyclic compound, 877264-43-2, name is (5-Fluoro-2-iodophenyl)methanol, molecular formula is C7H6FIO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 : Compound 10 (1.89 g, 7.5 mmol), compound 29 (2.28 g, 9 mmol), and cesium carbonate (6.1 1 g, 18.7 mmol) were combined in acetonitrile (75 mL), and heated at 80C for 18 hours. The crude suspension was added to brine (400 mL) and the resulting rust colored solids were collected by filtration and rinsed with water. The partially dried solids were recrystallized from hot acetonitrile (-200 mL) to afford compound 436 (2.37 g, 75%) as an orange solid. 1H NMR (400 MHz, DMSO-d6) delta 7.92 (dd, 1 H), 7.58 – 7.69 (m, 2 H), 7.05 (td, J = 8.65, 3.24 Hz, 1 H), 6.69 (s, 2 H), 5.27 (s, 2 H). LCMS m/z 423/425 [M+H]+.

The synthetic route of 877264-43-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; BAILEY, Simon; BURKE, Benjamin, Joseph; COLLINS, Michael, Raymond; CUI, Jingrong, Jean; DEAL, Judith, Gail; HOFFMAN, Robert, Louis; HUANG, Qinhua; JOHNSON, Ted, William; KANIA, Robert, Steven; KATH, John, Charles; LE, Phuong, Thi, Quy; MCTIGUE, Michele, Ann; PALMER, Cynthia, Louise; RICHARDSON, Paul, Francis; SACH, Neal, William; WO2013/132376; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 2142-70-3, name is 1-(2-Iodophenyl)ethanone, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2142-70-3, Computed Properties of C8H7IO

General procedure: To a solution of the aryl iodide 1a-h (1 mmol) and the alkene 2or 5 (1.2 mmol) in CH3CN/H2O az. (1 M, 1 mL), triethylamine (TEA,1.2 mmol) and catalyst PdNP/-ZrPK (0.1 mol%, 1 mg) were added.The reaction mixture was stirred at 120C for 3 h with methyl acry-late (2) and for 4 h with styrene (5); the conversion of the aryliodide 1a-h was monitored by GLC analyses. The reaction mixturewas diluted with water (2 mL) and extracted with ethyl acetate(3 × 3 mL). The combined organic layers were dried with sodiumsulfate and evaporated under reduced pressure to give the products3a-h and 6a-h.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(2-Iodophenyl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Petrucci, Chiara; Cappelletti, Matteo; Piermatti, Oriana; Nocchetti, Morena; Pica, Monica; Pizzo, Ferdinando; Vaccaro, Luigi; Journal of Molecular Catalysis A: Chemical; vol. 401; (2015); p. 27 – 34;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 27913-58-2, A common heterocyclic compound, 27913-58-2, name is 4-(4-Iodophenyl)butanoic acid, molecular formula is C10H11IO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In one preparation, 428-aminoheptanoic acid: 10 mumol of 428 were stirred with 8 mumol of N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide (EDC) and 10 mumol of N- hydroxysuccinimide (NHS) in 50 mul of DMSO for 3 hours at 30 0C followed by addition of 20 mumol of 7-aminoheptanoic acid (Bachem) in 100 mul of 1 M NaHCO3, pH 9. The reaction was allowed to stir overnight at 30 0C. After quenching of remaining reagents with excess of Trizma base the reaction was purified by HPLC and characterized by mass spectrometry.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; PHILOCHEM AG; WO2008/53360; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 13194-68-8, name is 4-Iodo-2-methylaniline, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13194-68-8, category: iodides-buliding-blocks

A cold (O0C) suspension of 5-iodo-2-methylaniline (7.Og, 0.03M) in HCl (5M, 30ml) was treated dropwise with a solution of sodium nitrite (2.28g, 0.033mmol) in water (3ml) over 20 minutes. The solution was stirred for 20 minutes before sodium azide was added portionwise over 15 minutes. The mixture was stirred for 30 minutes then poured into water. The mixture was diluted with DCM and the pH adjusted to 7 by the addition of Na2COa. The phases were separated and the organic layer was dried (MgSO4) and concentrated under vacuum. . The residue was purified by chromatography (silica, 5% Et2O/hexanes followed by 10% EtOAc/Hexanes) to give the azide (5.1g, 64%). 1H NMR (500 MHz, CDCl3): delta 2.14 (3H, s), 6.88 (IH, d, J 7.9), 7.35 (IH, d, J 7.9), 7.39 (IH, d, J 1.3).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Iodo-2-methylaniline, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2006/43064; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 103440-52-4, name is Methyl 2-Iodo-5-methylbenzoate, A new synthetic method of this compound is introduced below., SDS of cas: 103440-52-4

General procedure: This kind of general experimental procedure is based on our already published procedure.13 The general procedure (GP) was carried out with ortho-iodoester 1a-d (105.0-136.0 mg, 0.40 mmol) and aldehyde 2a-k (195.0-313.0 mg, 1.6 mmol) in the presence of Pd(OAc)2 (5.0 mg, 5 mol%), Ag2O (111.3 mg, 0.48 mmol), and TBHP (257.1 mg, 2.0 mmol) allowing the reaction mixture to stir at 120 C for 12-20 h. Progress of the reaction was monitored by TLC until the ortho-iodoester 1a-d had completely reacted. Then the reaction mixture was removed from the oil bath and allowed to reach r.t. DCE (2 mL) and concd H2SO4 (1.0 mL) were added and the mixture was stirred at 60 C for 5 min to 2 h. Progress of the product formation was monitored by TLC until the reaction was complete. The mixture was quenched by the addition of aq NaHCO3 and then extracted with CH2Cl2 (3 * 15 mL). The combined organic layers were washed with brine, dried (Na2SO4), and filtered. Evaporation of the solvent under reduced pressure and purification of the crude material by silica gel column chromatography (PE/EtOAc) furnished the products 3 (57.0-86.0 mg, 55-69%). The products 3aa, 3ac, 3ai, 3aj, 3ak, 3ba, 3bc, 3be, and 3bj are reported in the literature.9

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Suchand, Basuli; Satyanarayana, Gedu; Synthesis; vol. 51; 3; (2019); p. 769 – 779;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 13421-13-1, A common heterocyclic compound, 13421-13-1, name is 4-Chloro-2-iodobenzoic acid, molecular formula is C7H4ClIO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Chloro-2-(2H-I ,2,3-triazol-2-yI)benzoic acid (A-I -I)Cs2CO3 (12.0 g, 37 mmol) was added portionwise to a rt solution of commercially available 4-chloro-2-iodobenzoic acid (5.22 g, 18.5 mmol) in DMF (25 mL) followed by 1H-1,2,3-triazole(1.61 mL, 27.8 mmol) and Cu(l)l (210 mg, 1.1 mmol). The resulting blue suspension was stirredat 120C for 30 mm, then the rxn mixture was quenched with 2M aq. HCI and filtered through acelite plug before being extracted with DCM (3x). The combined org. layers were dried (Na2SO4), filtered and evaporated in vacuo to give the crude product that was purified by FC (Biotage SP1: eluting with DCM/MeOH 95:5 + 0.1% AcOH) to give the title compound A-I-I as a brown solid. LC-MSA: tR= 0.66 mm; [M(35Cl)+H]= 224.10.

The synthetic route of 13421-13-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BOLLI, Martin; BOSS, Christoph; BROTSCHI, Christine; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi T.; WO2014/141065; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 20691-72-9, A common heterocyclic compound, 20691-72-9, name is 4-Iodo-2-nitroaniline, molecular formula is C6H5IN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of (2-nitro-phenyl)-carbamic acid tert.-butyl esters from 2-nitroanilines Method a: To a solution of diphosgene (4.1 mL, 34.1 mmol) in EtOAc (40 mL) at 0 C. was added a solution of the 4-iodo-2-nitroaniline (45.5 mmol) in EtOAc (200-500 mL), and the mixture was heated to reflux for 18 h. The solvent was removed in vacuum to leave a brown solid, which was triturated with hot hexane (200 mL). The solid material was filtered off and the filtrate was concentrated under reduced pressure to leave the pure 4-iodo-2-nitrophenylisocyanate as a yellow solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Hoffmann-la Roche Inc.; US6407094; (2002); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 825-98-9, name is 3-Fluoro-4-iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H4FIO2

To a solution of 3-fluoro-4-iodobenzoic acid (step-lof Intennediate-27, 1.0 g, 3.75 mmol) inDCM (20.0 mL) was added oxalyl chloride (947 mg, 7.57 mmol) and stirred at ft for 3-4 h.Meanwhile, to a solution of 2-(dimethylamino)ethanol (501 mg, 5.63 mmol) in THF (20.0 mL)was added Et3N (759 mg, 7.51 mmol) and stirred for 5-10 mins followed by addition of aboveprepared acid chloride solution. The reaction mass was stirred at rt for 16 h before it wasquenched with water and extracted with DCM. The organic layer was concentrated to afford400 mg of title product. ?H NMR (300 MHz, DMSO-d6): 10.54 (br s, 1H), 8.08-8.03 (t, J =7.8 Hz, 1H), 7.95-7.91 (d, J = 9.3 Hz, 1H), 7.68-7.66 (m, 1H), 4.59 (t, 2H), 3.50 (br s, 2H),2.84 (s, 6H); MS [M+Hj: 338.

According to the analysis of related databases, 825-98-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; MUTHUKAMAN, Nagarajan; PISAL, Dnyandeo; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy Manish; KADAM, Sheetal R; (303 pag.)WO2016/55947; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 32024-15-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 32024-15-0 name is 3-Iodo-4,5-dimethoxybenzaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-Acetylnaphthalene (511 mg, 3.0 mmol) was dissolved in MeOH (10 mL) and 3-iodo-4,5-dimethoxybenzaldehyde (876 mg, 3.0 mmol) was added. 5% NaOH (3.0 mL) was added and the reaction mixture was stirred at room temperature for 16 h. The formed precipitate was collected, washed with MeOH and dried in vacuum. Yield: 1.127 g (2.54 mmol, 85%);

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Iodo-4,5-dimethoxybenzaldehyde, and friends who are interested can also refer to it.

Reference:
Article; Schmitt, Florian; Draut, Heidrun; Biersack, Bernhard; Schobert, Rainer; Bioorganic and Medicinal Chemistry Letters; vol. 26; 21; (2016); p. 5168 – 5171;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com